Hydroxypropyl Methyl Cellulose HPMC

Hydroxypropyl methylcellulose(HPMC) he cellulose derivative i hoʻohana mau ʻia i nā ʻoihana like ʻole, me nā lāʻau lapaʻau, meaʻai, kūkulu hale, a me ka mālama pilikino. Hana ʻia ia ma ke kemika hoʻololi ʻana i ka cellulose ma o ka etherification, e pili ana i ka hoʻokomo ʻana i nā pūʻulu hydroxypropyl a me methyl i loko o ka mole cellulose.

He keʻokeʻo a keʻokeʻo keʻokeʻo ʻo HPMC i hiki ke hoʻoheheʻe ʻia i loko o ka wai a hana i kahi hopena akaka. Loaʻa iā ia nā waiwai like ʻole e pono ai i nā noi like ʻole. No ka laʻana, he mānoanoa, stabilizer, a emulsifier i nā huahana meaʻai. I ke kūkulu ʻana, hoʻohana ʻia ia ma ke ʻano he mea mālama wai i ka sima a me ka mortar e hoʻomaikaʻi i ka hana a pale i ka haki. I nā huahana mālama pilikino, hoʻohana ʻia ia e like me ka mānoanoa a me ka emulsifier i loko o nā lotions, creams, a me nā huahana ʻē aʻe.

I loko o nā lāʻau lapaʻau, hoʻohana ʻia ka HPMC ma ke ʻano he mea hoʻopaʻa, disintegrant, a me ka mea hoʻokuʻu hoʻokuʻu ʻia i nā papa a me nā capsules. Hoʻohana ʻia ʻo ia ma ke ʻano he mea hoʻokuʻu ʻia i nā ʻano wai a me ka lubricant i nā ʻaila a me nā ʻaila. ʻO ka HPMC kahi mea kōkua nui i ʻae ʻia i ka ʻoihana lāʻau lapaʻau ma muli o kona biocompatibility, palekana, a me ka haʻahaʻa haʻahaʻa.

Loaʻa i ka HPMC kekahi mau māka me nā pae viscosity like ʻole, i koho ʻia e ke code helu. ʻO ke kiʻekiʻe o ka helu, ʻoi aku ka kiʻekiʻe o ka viscosity. Loaʻa nā māka HPMC mai ka viscosity haʻahaʻa (5 cps) a hiki i ka viscosity kiʻekiʻe (100,000 cps). He mea koʻikoʻi ka viscosity o HPMC i ka hoʻoholo ʻana i kāna mau waiwai a me nā noi.

Ua ulu ka hoʻohana ʻana o HPMC i nā lāʻau lapaʻau i nā makahiki i hala iho nei ma muli o kāna mau waiwai nui a me ka piʻi nui ʻana o ka noi no nā ʻōnaehana lawe lāʻau hou. Ua hoʻohana ʻia nā hydrogels e pili ana i ka HPMC i nā ʻōnaehana lawe lāʻau ma muli o ko lākou biocompatibility, hoʻokuʻu ʻia, a me nā waiwai mucoadhesive. Ua hoʻomohala pū ʻia nā papa ma ka HPMC me nā waiwai hoʻokuʻu i hoʻololi ʻia e hiki ai ke hāʻawi i ka lāʻau lapaʻau i manaʻo ʻia a hoʻomaikaʻi i ka mālama ʻana i nā mea maʻi.

Eia naʻe, ʻaʻole ʻo HPMC me nā palena ʻole. ʻAʻole hiki ke hoʻoheheʻe ʻia i loko o nā mea hoʻoheheʻe organik a paʻakikī i nā loli pH. Eia kekahi, he palena wela kona a hiki ke nalowale kona viscosity i nā wela kiʻekiʻe. Ua alakaʻi kēia mau palena i ka hoʻomohala ʻana i nā derivatives cellulose ʻē aʻe, e like me ka hydroxyethyl cellulose (HEC) a me ka carboxymethyl cellulose (CMC), i hoʻomaikaʻi i nā waiwai a me nā pae noi ākea.

I ka hopena, ʻo ka HPMC kahi derivative cellulose versatile i hoʻohana nui ʻia i nā ʻoihana like ʻole, ʻoi loa i nā lāʻau lapaʻau. ʻO kāna mau waiwai kūʻokoʻa, me kona biocompatibility, palekana, a me ka haʻahaʻa haʻahaʻa, e lilo ia i mea hoʻohiwahiwa kaulana i nā hana lāʻau. Ua hōʻike ʻia nā ʻōnaehana hoʻopuka lāʻau ma HPMC i ka hoʻomaikaʻi ʻana i ka pono o ka lāʻau a me ka mālama ʻana i ka maʻi. Eia naʻe, ʻo kona mau palena i ka solubility a me ka pH sensitivity ua alakaʻi i ka hoʻomohala ʻana i nā derivatives cellulose ʻē aʻe me nā waiwai i hoʻomaikaʻi ʻia.