ʻO ka Hydroxypropyl methylcellulose HPMC kahi ʻano o ka non-ionic cellulose i hui ʻia eter. ʻOkoʻa me ka ionic methyl carboxymethyl cellulose mixed ether, ʻaʻole ia e pane me nā metala kaumaha. Ma muli o nā ʻano like ʻole o ka methoxyl content a me ka hydroxypropyl content i loko o ka hydroxypropyl methylcellulose a me nā viscosities like ʻole, nui nā ʻano like ʻole me nā waiwai like ʻole, no ka laʻana, kiʻekiʻe methoxyl maʻiʻo a me ka haʻahaʻa hydroxypropyl haʻahaʻa. ʻO ka haʻahaʻa methoxy haʻahaʻa a me ka hydroxypropyl kiʻekiʻe ma kahi kokoke i ka hydroxypropyl methyl cellulose. Eia nō naʻe, i loko o kēlā me kēia ʻano, ʻoiai he liʻiliʻi wale nō o ka pūʻulu hydroxypropyl a i ʻole kahi pūʻulu methoxyl liʻiliʻi i loaʻa, ʻokoʻa loa ka solubility i nā mea hoʻoheheʻe organik a i ʻole ka mahana flocculation i loko o ka wai.
1. Ka solubility o ka hydroxypropyl methylcellulose
①Solubility o ka hydroxypropyl methylcellulose i loko o ka wai Hydroxypropyl methylcellulose he ʻano methylcellulose maoli nō ia i hoʻololi ʻia e propylene oxide (methoxypropylene), no laila ua like nā ʻano like me ka methyl cellulose He ʻano like ka cellulose o ka solubility wai anuanu a me ka wai wela. Eia naʻe, ma muli o ka pūʻulu hydroxypropyl i hoʻololi ʻia, ʻoi aku ka kiʻekiʻe o ka mahana gelation i ka wai wela ma mua o ka methyl cellulose. No ka laʻana, ka viscosity o hydroxypropyl methylcellulose aqueous solution me 2% methoxy content substitution degere DS=0.73 a me ka hydroxypropyl content MS=0.46 he huahana o 500 mpa?s ma 20°C, a me kona wela gel Hiki ke hiki kokoke i 100° C, ʻoiai ʻo ka methyl cellulose ma ka mahana like ma kahi o 55°C wale nō. No kona hoʻoheheʻe ʻana i ka wai, ua hoʻomaikaʻi nui ʻia. No ka laʻana, hiki ke kūʻai ʻia ka pulverized hydroxypropyl methylcellulose (kahi huahana me ka nui o 0.2 ~ 0.5mm a me ka 4% aqueous solution viscosity o 2pa?s ma 20 ° C hiki ke kūʻai ʻia ma Ma ka lumi wela, hiki ke hoʻoheheʻe ʻia i ka wai me ka ʻole o ka hoʻoluʻu. .
②Solubility o ka hydroxypropyl methylcellulose i loko o nā mea hoʻoheheʻe kūlohelohe ʻoi aku ka maikaʻi o ka solubility o ka hydroxypropyl methylcellulose i nā mea hoʻoheheʻe organik ma mua o ka methylcellulose. No nā huahana ma luna o 2.1,kiʻekiʻe-viscosity hydroxypropyl methylcelluloseLoaʻa i ka hydroxypropyl MS = 1.5 ~ 1.8 a me ka methoxy DS = 0.2 ~ 1.0, me ka nui o ka hoʻololi ʻana ma luna o 1.8, hiki ke hoʻoheheʻe ʻia i ka methanol anhydrous a me ka ethanol solution Medium, a me ka thermoplastic a me ka wai. Hiki ke hoʻoheheʻe ʻia i loko o nā hydrocarbons chlorinated e like me ka methylene chloride a me ka chloroform, a me nā mea hoʻoheheʻe kūlohelohe e like me ka acetone, isopropanol a me ka waiʻona diacetone. ʻOi aku ka maikaʻi o kona hoʻoheheʻe ʻana i nā mea hoʻoheheʻe organik ma mua o ka hoʻoheheʻe wai.
2. Nā mea e pili ana i ka viscosity o ka hydroxypropyl methylcellulose
Nā mea e hoʻololi ai i ka viscosity o Hydroxypropyl Methyl Cellulose ʻO ka hoʻoholo ʻana i ka viscosity maʻamau o ka hydroxypropyl methyl cellulose ua like ia me nā cellulose ethers ʻē aʻe. Ua ana ia ma 20°C me 2% aqueous solution ma ke ano ma'amau. Hoʻonui ka viscosity o ka huahana like me ka piʻi ʻana o ka ʻike. No nā huahana me nā kaumaha molekala like ʻole i ka ʻike like, ʻoi aku ka nui o ka viscosity o ka huahana me ke kaumaha molekala nui. Ua like kona pilina me ka wela me ka methyl cellulose. Ke piʻi ka mahana, hoʻomaka ka viscosity e emi, akā i ka hiki ʻana i kahi mahana, piʻi koke ka viscosity a puka ka gelation. ʻOi aku ka kiʻekiʻe o ka mahana gel o nā huahana haʻahaʻa-viscosity. kiʻekiʻe. ʻAʻole pili wale kāna helu gel i ka viscosity o ka ether, akā pili pū kekahi i ka ratio haku mele o ka hui methoxyl a me ka hui hydroxypropyl i ka ether a me ka nui o ka huina hoʻololi. Pono e hoʻomaopopo ʻia he pseudoplastic nō hoʻi ka hydroxypropyl methylcellulose, a paʻa kona hopena i ka mahana o ka lumi me ka ʻole o ka degradation o ka viscosity koe wale nō ka hiki ke hoʻohaʻahaʻa i ka enzymatic.
3. ʻO ka Hydroxypropyl methylcellulose ke kū'ē i ka waika a me ka alkali
ʻO ka hydroxypropyl methylcellulose acid a me ke kūpaʻa alkali Hydroxypropyl methylcellulose maʻamau i paʻa i nā waikawa a me nā alkalis, ʻaʻole pili i ka pae o ka pH 2 ~ 12. Hiki iā ia ke pale i kahi nui o ka waikawa māmā, E like me formic acid, acetic acid, citric acid, succinic acid, phosphoric acid, boric acid, etc. Akā ʻo ka waikawa concentrated ka hopena o ka hoʻemi ʻana i ka viscosity. ʻAʻohe hopena o ka alkali e like me ka soda caustic, caustic potash a me ka wai lime, akā hiki iā lākou ke hoʻonui iki i ka viscosity o ka hopena, a laila hoʻemi mālie.
4. Ka miscibility o ka hydroxypropyl methylcellulose
Hiki ke hoʻohui ʻia ka waiʻona hydroxypropyl methylcellulose Hydroxypropyl methylcellulose me nā pūhui polymer hiki ke hoʻoheheʻe ʻia i ka wai e lilo i ʻano like ʻole a me ka ʻākala me ka viscosity kiʻekiʻe. ʻO kēia mau pūhui polymer ka polyethylene glycol, polyvinyl acetate, polysilicone, polymethylvinylsiloxane, hydroxyethyl cellulose, a me ka methyl cellulose. ʻO nā pūhui molekala kiʻekiʻe kūlohelohe e like me ka gum arabic, ka ʻūhini ʻūhini, ka karaya gum, a me nā mea ʻē aʻe he kūpono maikaʻi me kāna hoʻonā. Hiki ke hui pū ʻia ka Hydroxypropyl methylcellulose me ka ester mannitol a i ʻole sorbitol ester o ka waikawa stearic a i ʻole ka palmitic acid, a hiki ke hui pū ʻia me ka glycerin, sorbitol a me ka mannitol, a hiki ke hoʻohana ʻia kēia mau pūhui e like me ka hydroxypropyl methylcellulose Plasticizer no cellulose.
5. Insolubilization a me ka wai solubility o hydroxypropyl methylcellulose
Hiki ke hoʻopaʻa ʻia nā etera cellulose hiki ʻole ke hoʻoheheʻe ʻia i ka wai o ka hydroxypropyl methylcellulose me nā aldehydes ma luna o ka ʻili, no laila e hoʻoheheʻe ʻia kēia mau eter hiki ke hoʻoheheʻe ʻia i ka wai i loko o ka hopena a lilo i mea hiki ʻole ke hoʻoheheʻe ʻia i ka wai. ʻO nā aldehydes e hana ai i ka hydroxypropyl methylcellulose hikiʻole ke hoʻoheheʻe i ka formaldehyde, glyoxal, succinic aldehyde, adipaldehyde, a me nā mea'ē aʻe. mea kūʻai ma ka hana ʻoihana. ʻO ka nui o kēia ʻano mea hoʻohui keʻa i ka hopena he 0.2% ~ 10% o ka nui o ka etera, ʻoi aku ka maikaʻi o 7% ~ 10%, no ka laʻana, ʻo 3.3% ~ 6% o glyoxal ka mea kūpono loa. ʻO ka mahana mālama maʻamau he 0 ~ 30 ℃, a ʻo ka manawa he 1 ~ 120min. Pono e hoʻokō ʻia ka hopena hoʻopili keʻa ma lalo o nā kūlana acidic. ʻO ka mea maʻamau, hoʻohui mua ʻia ka hopena me ka waika ikaika inorganic a i ʻole ka waikawa carboxylic organik e hoʻoponopono ai i ka pH o ka hopena ma kahi o 2 ~ 6, ʻoi aku ka maikaʻi ma waena o 4 ~ 6, a laila hoʻohui i nā aldehydes e hoʻokō i ka hopena cross-linking. ʻO ka waika i hoʻohana ʻia he waika hydrochloric, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxyacetic acid, succinic acid a citric acid etc., kahi e pono ai me ka formic acid a i ʻole acetic acid, a ʻoi aku ka maikaʻi o ka waikawa formic. Hiki ke hoʻohui ʻia ka ʻakika a me ka aldehyde i ka manawa like e ʻae i ka hoʻonā e hoʻokō i kahi hopena hoʻohui i loko o ka pae pH makemake ʻia. Hoʻohana pinepine ʻia kēia hopena i ka hana hope loa i ka hoʻomākaukau ʻana o ka cellulose ethers. Ma hope o ka hiki ʻole o ka cellulose ether, hiki ke holoi a hoʻomaʻemaʻe me ka wai ma 20 ~ 25 ° C. Ke hoʻohana ʻia ka huahana, hiki ke hoʻohui ʻia nā mea alkaline i ka hopena o ka huahana e hoʻoponopono i ka pH o ka hopena i alkaline, a e hoʻoheheʻe koke ka huahana i ka hopena. Hoʻopili pū ʻia kēia ʻano hana i ka mālama ʻana i ke kiʻiʻoniʻoni ma hope o ka hana ʻana o ka cellulose ether solution i kiʻiʻoniʻoni e hana i kahi kiʻiʻoniʻoni insoluble.
6. Ke kū'ē i ka enzyme o ka hydroxypropyl methylcellulose
ʻO ke kūpaʻa enzyme o ka hydroxypropyl methylcellulose he derivatives cellulose theoretically, e like me kēlā me kēia hui anhydroglucose, inā aia kahi pūʻulu substituent paʻa paʻa, ʻaʻole maʻalahi ka maʻi ʻana e nā microorganisms, akā ʻoiaʻiʻo ka huahana i hoʻopau ʻia. e hoʻohaʻahaʻa ʻia hoʻi e nā enzymes, ʻo ia hoʻi ʻaʻole i lawa pono ke ʻano o ka hoʻololi ʻana o kēlā me kēia hui ma ke kaulahao cellulose, a hiki i nā microorganisms ke hoʻopau i ka pūʻulu anhydroglucose i hoʻololi ʻole ʻia e hana i nā sugars, e like me nā meaʻai no nā microorganisms e komo. No laila, inā piʻi ka degere o ka hoʻololi ʻana i ka cellulose, e piʻi pū ke kū'ē i ka erosion enzymatic o cellulose ether. Wahi a nā hōʻike, ma lalo o nā kūlana i kāohi ʻia, nā hopena hydrolysis o nā enzymes, ke koena o ka viscosity o hydroxypropyl methylcellulose (DS = 1.9) he 13.2%, methylcellulose (DS = 1.83) he 7.3%, methylcellulose (DS = 1.66) he 3.8%, a he 1.7% ka hydroxyethyl cellulose. Hiki ke ʻike ʻia he ikaika anti-enzyme ka hydroxypropyl methylcellulose. No laila, ʻo ke kūpaʻa enzyme maikaʻi loa o ka hydroxypropyl methylcellulose, i hui pū ʻia me kona dispersibility maikaʻi, ka mānoanoa a me nā waiwai hana kiʻiʻoniʻoni, hoʻohana ʻia i nā uhi wai-emulsion, etc., a ʻaʻole pono e hoʻohui i nā preservatives. Eia nō naʻe, no ka mālama lōʻihi o ka hopena a i ʻole ka hoʻohaumia ʻana mai waho, hiki ke hoʻohui ʻia nā preservatives i mea e mālama ai, a hiki ke hoʻoholo ʻia ke koho e like me nā koi hope o ka hopena. ʻO ka Phenylmercuric acetate a me ka manganese fluorosilicate nā mea mālama pono, akā loaʻa iā lākou a pau ka Toxicity, pono e uku ʻia ka nānā ʻana i ka hana. ʻO ka maʻamau, hiki ke hoʻohui ʻia ka 1 ~ 5mg o ka phenylmercury acetate i ka hopena no ka lita o ke ʻano.
7. Ka hana o ka membrane hydroxypropyl methylcellulose
ʻO ka hana o ka hydroxypropyl methylcellulose film Hydroxypropyl methylcellulose he waiwai kiʻiʻoniʻoni maikaʻi loa. Hoʻopili ʻia kāna ʻano wai a i ʻole ka mea hoʻoheheʻe organik ma luna o kahi pā aniani, a lilo ia i kala ʻole a ʻākala ma hope o ka maloʻo ʻana. A kiʻiʻoniʻoni paʻakikī. He kūpaʻa maikaʻi kona maʻamau a paʻa mau i nā wela kiʻekiʻe. Inā hoʻohui ʻia ka plasticizer hygroscopic, hiki ke hoʻonui ʻia kona elongation a me ka maʻalahi. Ma ke ʻano o ka hoʻomaikaʻi ʻana i ka maʻalahi, ʻo nā plasticizers e like me glycerin a me sorbitol ka mea kūpono loa. ʻO ka maʻamau, ʻo 2% ~ 3% ka hopena o ka hopena, a ʻo ka nui o ka plasticizer he 10% ~ 20% o cellulose ether. Inā kiʻekiʻe loa ka ʻike o ka plasticizer, e hoʻemi ʻia ka colloidal dehydration i ka haʻahaʻa haʻahaʻa. ʻO ka ikaika tensile o ke kiʻi i hoʻohui ʻia me ka plasticizer ʻoi aku ka nui ma mua o ka mea ʻole me ka hoʻohui ʻole, a hoʻonui ʻia me ka hoʻonui ʻana o ka nui i hoʻohui ʻia, a piʻi pū ka hygroscopicity o ke kiʻi me ka piʻi ʻana o ka nui o ka plasticizer.
Ka manawa hoʻouna: Dec-19-2022