ʻO Hydroxypropylmethylcellulose (HPMC) he cellulose ether i hoʻohana nui ʻia i nā ʻoihana e like me nā lāʻau lapaʻau, nā mea hoʻonaninani, nā meaʻai, a me ke kūkulu ʻana. Ma muli o kona maʻalahi a me nā waiwai pono, ua lilo ʻo HPMC i mea hoʻohui kaulana i nā ʻano hana like ʻole. I kēia manawa, nui nā ʻano HPMC ma ka mākeke, kēlā me kēia me nā waiwai a me nā noi.
ʻO ka HPMC kahi polymer cellulose i hoʻololi kemika i loaʻa ma ka hana ʻana i ka cellulose me ka methyl chloride a me ka propylene oxide. Hoʻokomo kēia hopena i nā pūʻulu methyl a me hydroxypropyl i loko o ka hale cellulose, e hana ana i ka polymer hiki ke hoʻoheheʻe wai, non-ionic a me ka hana kiʻekiʻe. Eia nō naʻe, loaʻa i nā ʻano HPMC like ʻole nā degere o ka hoʻololi ʻana (DS) o nā pūʻulu methyl a me hydroxypropyl, ka mea e hoʻoholo ai i ko lākou mau waiwai kino a me kemika.
ʻO ka maʻamau, ua helu ʻia nā huahana HPMC e like me ka viscosity a me ka waiwai DS. He waiwai koʻikoʻi ka viscosity o HPMC no ka mea e pili ana i ka solubility o ka huahana, ka hiki ke hana kiʻiʻoniʻoni a me ka hiki ke mānoanoa. Ma ka ʻaoʻao ʻē aʻe, ʻo ka waiwai DS e hoʻoholo i ka degere o ka hoʻololi ʻana o ka polymer a pēlā ke ʻano o ka hydrophobicity o ke ʻano HPMC. No laila, loaʻa nā ʻano HPMC like ʻole ma o nā ʻano like ʻole o kā lākou viscosity a me nā waiwai DS. Aia ma lalo iho nā ʻano maʻamau o HPMC a pehea ko lākou ʻokoʻa.
1. HPMC papa ma'amau
He methyl DS ka HPMC mai ka 0.8 a hiki i ka 2.0 a me ka hydroxypropyl DS mai ka 0.05 a hiki i ka 0.3. Loaʻa kēia ʻano HPMC ma kahi ākea o nā māka viscosity mai 3cps a i 200,000cps. ʻO ka HPMC papa maʻamau ka hiki ke hoʻoheheʻe maikaʻi ʻia i ka wai a hana i nā hāʻina akaka, kūpono ia no nā noi like ʻole i ka ʻoihana meaʻai, lāʻau lapaʻau a me nā ʻoihana hoʻonaninani. Hoʻohana maʻamau ia mau HPMC ma ke ʻano he kiʻiʻoniʻoni, mānoanoa, emulsifiers a me nā stabilizers i ka meaʻai a me nā mea hoʻonaninani.
2. HPMC pani haʻahaʻa
Loaʻa i ka HPMC kahi haʻahaʻa o ka methyl a me ka hydroxypropyl substitution ma mua o ka HPMC papa maʻamau. He methyl DS kēia ʻano HPMC mai 0.2 a 1.5 a me kahi hydroxypropyl DS mai 0.01 a 0.2. ʻO nā huahana HPMC hoʻololi haʻahaʻa he haʻahaʻa ka viscosity, maʻamau ma waena o 3-400cps, a kūpaʻa loa i ka paʻakai a me nā enzymes. Hāʻawi kēia mau waiwai i ka HPMC haʻahaʻa haʻahaʻa i kūpono no nā huahana meaʻai e like me ka waiū, ka palaoa a me nā huahana ʻiʻo. Eia kekahi, hoʻohana ʻia ka HPMC haʻahaʻa haʻahaʻa ma ke ʻano he mea hoʻopaʻa, disintegrant a me ka mea hoʻopili papa ma ka ʻoihana lāʻau.
3. HPMC pani kiʻekiʻe
Loaʻa i ka HPMC kahi kiʻekiʻe o ka methyl a me ka hydroxypropyl substitution ma mua o ka HPMC papa maʻamau. ʻO kēia ʻano HPMC he methyl DS mai 1.5 a 2.5 a me kahi hydroxypropyl DS mai 0.1 a 0.5. ʻO nā huahana HPMC i hoʻololi nui ʻia he ʻoi aku ka viscosity, mai ka 100,000cps a i ka 200,000cps, a he mau waiwai paʻa wai ikaika. Hoʻohana kēia mau waiwai i ka HPMC kūpono no ka hoʻohana ʻana i ka ʻoihana kūkulu, e like me nā huahana sima, nā uhi a me nā mea hoʻopili. Hoʻohana ʻia ʻo HPMC i hoʻololi ʻia ma ke ʻano he mea hoʻopaʻa, mānoanoa a me ka mea hoʻokuʻu i ka ʻoihana lāʻau.
4. Methoxy-Ethoxy HPMC
ʻO Methoxy-Ethoxy HPMC kahi ʻano HPMC i hoʻolālā kūikawā ʻia me kahi kiʻekiʻe o ka hoʻololi ethoxy. ʻO nā hui ethoxy e hoʻonui i ka hydrophobicity o HPMC, e hoʻemi iki i ka wai ma mua o ka HPMC papa maʻamau. Me ka methyl DS mai ka 1.5 a hiki i ka 2.5 a me ka ethoxy DS mai ka 0.4 a hiki i ka 1.2, methoxy-ethoxy HPMC he mea kūpono ia no ka hoʻohana ʻana i nā huahana aila e like me nā mea hoʻonaninani, nā pena a me nā uhi. Hoʻokumu kēia ʻano HPMC i kahi kiʻiʻoniʻoni kūpaʻa a ʻaʻahu hoʻi e hāʻawi i kahi hoʻopau ʻālohilohi i ka huahana hope.
5. Granular HPMC
ʻO Granular HPMC kahi ʻano o ka HPMC i loaʻa kahi ʻāpana liʻiliʻi, maʻamau ma waena o 100-200 microns. Hoʻohana ʻia ʻo Granular HPMC i ka ʻoihana lāʻau lapaʻau ma ke ʻano he mea hoʻopaʻa papa, disintegrant a me ka mea hoʻokuʻu mau. ʻO ka liʻiliʻi liʻiliʻi o nā ʻāpana HPMC e hiki ai ke hoʻohele like i nā mea ʻai, e hopena i kahi huahana kūpaʻa a hilinaʻi. He methyl DS ka Granular HPMC mai ka 0.7 a hiki i ka 1.6 a me ka hydroxypropyl DS mai ka 0.1 a hiki i ka 0.3.
ʻO ka Hydroxypropylmethylcellulose (HPMC) he polymer multifunctional me ka nui o nā noi i nā ʻoihana like ʻole. Hoʻokaʻawale ʻia nā ʻano HPMC e like me ka viscosity a me ka waiwai DS, ka mea e hoʻoholo ai i kā lākou mau waiwai kino a me nā kemika. ʻO HPMC papa maʻamau, HPMC pani haʻahaʻa, HPMC pani kiʻekiʻe, HPMC methoxyethoxy a me HPMC granular nā ʻano maʻamau o HPMC. ʻO ka hoʻomaopopo ʻana i ka ʻokoʻa ma waena o kēia mau ʻano e hiki ai i nā mea hoʻokumu ke hoʻohana i ka mana piha o nā HPMC e hana i nā huahana hopena kiʻekiʻe a ikaika.
Ka manawa hoʻouna: Sep-06-2023