ʻO ka mea mua, ʻo ka pōkole Pelekane o nā mea kōkua
MC: Methyl cellulose
EC: ethyl cellulose
HPC: hydroxypropyl cellulose
HPMC: hydroxypropyl methylcellulose
CAP: Cellulose acetate phthalates
HPMCP: hydroxypropyl cellulose phthalates
HPMCAS: hydroxypropyl methyl cellulose acetate succinate
Cmc-na: Sodium carboxymethyl cellulose
MCC: Microcrystalline cellulose
PVP: Povidone
PEG: polyethylene glycol
PVA: Polyvinyl alcohol
Cms-na: Sodium carboxymethyl starch
PVPP: Povidone pili kea
CCNa: crosslinked sodium carboxymethyl cellulose
ʻElua, ka hoʻohana ʻana i kekahi mau mea kōkua
1. Lactose: papa: mea hoʻopiha, ʻoi aku ka pauka pololei papa piha;Injection: mea pale lyophilized
2. Microcrystalline cellulose: papa: ka pauka i kaomi pono i ka papa piha;"Hoʻopili maloʻo";ʻO nā papa i loaʻa he 20% microcrystalline cellulose e hana ma ke ʻano he disintegrators
3. Methyl cellulose: papa: adhesive;Mea hoʻokuʻu: kōkua hoʻokuʻu;Hoʻomākaukau hoʻokuʻu lohi (mālama): hydrophilic gel skeleton material (nāwaliwali)
4 sodium carboxymethyl cellulose: nā papa: hoʻopili;Mea hoʻokuʻu: kōkua hoʻokuʻu;Hoʻomākaukau hoʻokuʻu lohi (mālama): hydrophilic gel skeleton material
5. Ethyl cellulose: papa: adhesive (inoluble in water);Hoʻomākaukau hoʻokuʻu lohi (mālama ʻia): nā mea iwi iwi a i ʻole nā mea hoʻomalu membrane;Hoʻopuehu paʻa: insoluble lawe mea
6 hydroxypropyl cellulose: papa: paʻa, mea uhi kiʻiʻoniʻoni;Mea hoʻokuʻu: kōkua hoʻokuʻu;Hoʻomākaukau hoʻokuʻu lohi (kaohi): hydrophilic gel skeleton material, microporous membrane coated sheet pore-inducing agent
7. Hydroxypropyl methyl cellulose (hydroxypropyl methyl cellulose): papa: mea hoʻopili, mea uhi kiʻiʻoniʻoni;Mea hoʻokuʻu: kōkua hoʻokuʻu;Hoʻomākaukau hoʻokuʻu lohi a hoʻopaʻa ʻia: hydrophilic gel skeleton material, microporous membrane coated sheet pore-inducing agent
8. Cellulose acetate phthalates: mea komo
9. Hydroxypropyl cellulose phthalates: mea komo
10. Hydroxypropyl cellulose acetate succinate: mea komo
11. Polyvinyl phthalate (PVAP): mea komo
12. Styrene Maleic acid copolymer (StyMA) : mea hiki ke hoʻoheheʻe ʻia i loko o ka ʻōpū.
13. Acrylic resin (enteric type I, II, III), Eudragit L, Eudragit S (i kekahi manawa Eudragit L100 a i ʻole Eudragit S 100): mea komo
14.Eudragit RL, Eudragit RS: : Mea lawe ʻole ʻia
15.Eudragit E (e like me ka acrylic IV): ka mea hoʻoheheʻe polymer ʻōpū
16. Cellulose acetate: wai hiki ʻole ke hoʻohana ʻia no ka uhi ʻana a i ʻole ka hoʻomākaukau ʻana i nā papa osmotic pump.
17. Polyvinylpyrrolidone (povidone PVP): nā papa: nā mea hoʻopili;Papa: mea hoʻouhi kiʻiʻoniʻoni ʻōpū;Pellets: nifedipine pellets (solid dispersion);Mea hoʻokuʻu: kōkua hoʻokuʻu;
ʻO ka hoʻopuehu paʻa: mea lawe wai-soluble;Hoʻomākaukau hoʻokuʻu lohi (mālama): hydrophilic colloid skeleton material;Hoʻomākaukau hoʻokuʻu lohi (kaohi ʻia): ka mea hoʻoulu pore i loko o nā papa i uhi ʻia i ka membrane microporous
18. ʻO ka waiʻona polyvinyl: mea hana kiʻiʻoniʻoni: mea hana kiʻiʻoniʻoni, kōkua hoʻomaha
19. Mākaʻikaʻi Sodium carboxymethyl: papa: mea hoʻoheheʻe
20. Povidone pili kea: Papa: disintegrant
21. ʻO ka sodium carboxymethyl cellulose i hoʻohui ʻia: papa: mea hoʻoheheʻe
22. Haʻahaʻa-substituted hydroxypropyl cellulose: Papa: disintegrant
23. Polylactic acid: biodegradable polymer material, hoʻohana ʻia no ka hoʻomākaukau ʻana i nā microspheres, nanoparticles, etc.
24. Glycerol (ʻoi aku ka pili o ka sorbitol propylene glycol i ka glycerol)
ʻO ka hoʻomākaukau ʻana i ka wai: solvent, injection solvent, suspension aid, moisturizer
Plasticizer i loko o ka capsule a me ka mea uhi
Ointments, transdermal delivery systems: penetration promoters
E hoʻonui i ka pulu o nā lāʻau hydrophobic, osmotic pressure regulator ma intravenous fat emulsion
Glycerin gelatin (no ka ʻaila, suppositories, dispersion paʻa)
25. Glycerin gelatin
ʻO nā lāʻau hoʻoheheʻe: wai-soluble matrix
Suppository: wai-soluble matrix
Ka ʻaila: matrix hiki ke hoʻoheheʻe ʻia i ka wai
26. Sodium dodecyl sulfate
Emulsions, hamo: emulsifiers
Mea pulu no ka hoʻomākaukau paʻa/lubricant no nā papa
mea hoʻoheheʻe
27. Polyethylene glycol (PEG)
Nā Papa: Mea hoʻoheheʻe wai-soluble (PEG 4000, 6000)
Papa: Plasticizer i loko o ka palapala hoʻouhi kiʻiʻoniʻoni
Kāpena: ʻAiʻa wai ʻaʻole ʻaila ʻona (PEG 400)
ʻO nā lāʻau hoʻoheheʻe: matrix hiki ke hoʻoheheʻe wai (PEG 4000, 6000,9300)
Suppository: suppository matrix
Aerosol: Mea hoʻoheheʻe huna (PEG 400, 600)
Hoʻopili: Solvent (PEG 400, 600)
Hoʻomākaukau wai: Solvent (PEG 400, 600)
Hoʻopuehu paʻa: lawe
Hoʻomākaukau hoʻokuʻu lohi (kaohi ʻia): ka mea hoʻoulu pore i loko o nā papa i uhi ʻia i ka membrane microporous
Hoʻomākaukau ʻana i ka hoʻomaʻamaʻa ʻana: transdermal absorption enhancer
28. Poloxam (" zwitterionic "surfactant) Ua ʻike kekahi hoa makaʻala i kahi ʻokoʻa ma ʻaneʻi, i kēia manawa i hoʻoponopono ʻia i" Poloxam "non-ionic surfactant, ʻaʻole zwitterionic surfactant!
ʻO ka mea lawe hoʻopuehu paʻa, suppository matrix, emulsifier no ka injection a infusion paha
He hōʻuluʻulu o nā mea antiseptic a me bacteriostatic
Hydroxyl benzene ester (neper gula), benzoic acid, sodium benzoate, sorbic acid, benzalkonium bromide (hou hoʻomaʻemaʻe), benzalkonium chloride (jie er die), chlorhexidine acetate, benzyl alcohol (local pain) i ka manawa like, cross-linked me ka waiʻona butyl tertiary (ʻeha kūloko) i ka manawa like, nitrobenzene, mercury, thimerosal, disinfection net, ortho-phenyl phenol, phenoxyethanol, eucalyptus oil, cinnamon oil, peppermint oil, etc.
ʻEhā, sterilization method
1 / Glucose injection, momona emulsion no ka intravenous injection, dextran, sodium chloride infusion, rubber plug and other hot pressing sterilization;
2/ Huaʻai C injection, procaine hydrochloride injection, cortisone acetate injection, chloramphenicol eye drops i sterilized by circulating steam;
3/ ʻO ka ʻaila injection, grease matrix, ampoule me ka hoʻohana ʻana i ke ʻano sterilization wela maloʻo;
4/ Asepsis lumi lumi ea, hana ʻili papa: ultraviolet sterilization ala a i ʻole ke ʻano fumigation kinoea;
5/ Ka lima, nā mea hana aseptic: ke ʻano sterilization kemika
6/ Insulin injection a me nā huahana olaola ʻē aʻe: kānana sterilization ala
V. Na hoohalike pili
1. Noyes-whitney equation: e wehewehe ana i ka helu o ka hemo ana o na laau paa.
2. ʻO ka haʻahaʻa pili koʻikoʻi o ka hui ʻana
hygroscopicity o ka pauka P68)
3. Kumukuai panimanaʻo manaʻo P87)
4. Poiseuile formula: wehewehe i nā mea hoʻoikaika o ka kānana (injection P124)
5. Ka helu helu o ka hoʻoponopono isotonic ma ke ʻano hoʻohaʻahaʻa kiko hoʻoheheʻehoʻokomo P156)
6. Heluhelu i ka waiwai HLB o ka surfactant huikauwai P178)
ʻenehana hoʻomākaukau pili
1. Microcapsule: keʻano condensation (hoʻokahi, paʻakikī), keʻano solvent-non-solvent, hoʻololi i keʻano wela, keʻano hoʻomaloʻo wai, keʻano hoʻomaloʻo hoʻomaloʻo, keʻano o ka hoʻouluʻana, keʻano hoʻokuʻu ea, keʻano condensation interface, keʻano o ka radiation crosslinking
2. Hoʻohui pūhui: saturated aqueous solution method, grinding method, freeze drying method, spray drying method
3. Hoʻopuehu paʻa: keʻano hoʻoheheʻe, keʻano solvent, solvent - melting method, solvent - spray drying method, grinding method
4. Liposomes: ʻano hoʻoheheʻe ʻia, ʻano hoʻopuehu kiʻiʻoniʻoni lahilahi, ʻano hoʻopuehu kani ultrasonic, ʻano hoʻoheheʻe ʻana o ka manawa, ʻano hoʻomaloʻo maloʻo.
5. Nā Microspheres: emulsification - ke ʻano hoʻōla, ke ʻano hoʻomaloʻo ʻana, ke ʻano hoʻomaloʻo wai
6. Nanoparticles: micellar polymerization, emulsion polymerization, interfacial polymerization, ke ʻano hoʻomaloʻo wai.
7. Pellet: ka paila paila ʻana, ke ʻano o ka hoʻoheheʻe ʻana, ke ʻano o ka ipu hao, ke ʻano sphericity extrusion, ke ʻano projectile centrifugal, ke ʻano hoʻomaloʻo wai.
8 suppository: ʻano hoʻoheheʻe wela, ʻano kaomi anu, ʻano kneading
9. Ointment: keʻano wili, keʻano hoʻoheheʻe, keʻano emulsification
10 mea hana kiʻiʻoniʻoni: homogenized slurry flow film forming method, pressure-melting film forming method, composite film making method
ʻEhiku, nā mea hoʻonaninani
1. ʻO Microcapsule: gelatin - kāpī Arabic
2. Hoʻohui pūhui: cyclodextrin
3. Hoʻopuehu paʻa: PEG, PVP
4. Liposomes: phospholipid-cholesterol
5. Nā Microspheres: gelatin, albumin, PLA, etc
6. Suppository: ka pata koko
7. Ointment: Petroleum jelly, etc
8 mea hana kiʻiʻoniʻoni: PVA
ʻEwalu, he mau manawa
1. E waiho ʻia ka ampoule sterilized no nā hola 24;
2. ʻAʻole ʻoi aku ka nui o ka mālama ʻana i ka wai no ka injection;
3. Pono e ho'opau 'ia ka ho'oma'ema'e 'ia o nā inikini ma'amau i loko o 12 mau hola ma hope o ka ipuhao;
4. E hoʻopau ʻia ka infusion a me ka hoʻomākaukau ʻana i ka hopena i loko o 4 mau hola o ka sterilization
9. Nā mea nānā maikaʻi e pili ana i ka hoʻomākaukau lāʻau
1. Nā papa: nā hiʻohiʻona hiʻohiʻona;ʻOkoʻa kaumaha ʻāpana;ʻO ka paʻakikī a me ka palupalu;Degere disintegrating;Hoʻopau a hoʻokuʻu paha;Kaulike o ka maʻiʻo
2. Mea hoʻopuehu: uniformity;Māmā.Hoʻouka nui ʻokoʻa;Nānā olakino;Nānā granularity
3. Granule: helehelena;Ka nui o ka ʻāpana;Pohō kaumaha maloʻo;hehee;ʻO ka ʻokoʻa ukana
4. Capsule: helehelena;Māmā.Hoʻouka nui ʻokoʻa;ʻO ka weheʻana a me ka hemoʻana.
5. Hoʻokuʻu i nā lāʻau: ʻokoʻa kaumaha;Nānā palena manawa hoʻopau, etc.
6. Suppository: helehelena;ʻokoʻa i ke kaumaha;palena manawa hehee;Laulā helu heheʻe;ʻO ka hoʻāʻo in vitro dissolution a me ka in vivo absorption test
7. Pāpala: ka nui o ka ʻāpana;Ka ukana;Ka palena microbial;Maʻiʻo lāʻau nui;Nā waiwai kino;Hoʻoulu;Kupaa;Hoʻokuʻu, komo a me ka absorption o nā lāʻau i loko o ka hamo.
8. Nā pāpaʻi Transdermal: ʻokoʻa kaumaha;ʻokoʻa ʻāpana;Kaulike o ka maʻiʻo;Hoʻokuʻu degere, etc.
10. Nā wehewehe like ʻole
1. Micro capsule: he capsule liʻiliʻi ia i hana ʻia ma ke kāwili ʻana i kahi lāʻau paʻa a wai paha (i kapa ʻia ʻo capsule core) i loko o kahi mea polymer maoli a i ʻole synthetic (i kapa ʻia ʻo capsule material).1-5000 microns
2. Pellet: pili i ka mea spherical me ke anawaena ma lalo o 2.5mm i haku ʻia me nā lāʻau lapaʻau a me nā mea kōkua.
3. ʻO Microsphere: he ʻano iwi ʻano microscopic spherical skeleton i hana ʻia e ka hoʻoheheʻe ʻana a i ʻole ka hoʻopuehu ʻana i nā lāʻau lapaʻau ma ke ʻano o nā mea polymer, me ka nui o ka nui ma waena o 1 a me 250μm.
4. Nanoparticles: paʻa colloidal particles composed of polymeric substances, with particle size in the range of 10 ~ 1000nm.
5. ʻO ka mea hoʻoheheʻe pila: e pili ana i nā lāʻau paʻa a i ʻole wai a me nā mea kūpono (ʻike nui ʻia ʻo ka matrix) hui hoʻoheheʻe mehana, hāʻule i loko o ka condensate miscible, condensation contraction a hana ʻia me ka hoʻomākaukau ʻana i ka pellet liʻiliʻi.
Ka manawa hoʻouna: Sep-09-2022