Hydroxypyl methylcellose (hpmc)Shin ana amfani da polymer mai narkewa tare da aikace-aikace iri-iri, musamman a cikin magunguna, abinci, da samfuran kwaskwarima. Ikonsa na yin kauri, mafi kyawun mafi kyawun mafi kyawun lokacin da aka haɗe shi da ruwa ya sa ta hanyar sinadarai. Haɗin Kimacecellhphpmc mafita yana taka muhimmiyar rawa wajen tantance aikinsu a cikin tsari daban-daban. Fahimtar halayen danko na mafita na HPMC yana da mahimmanci don inganta amfanin su a cikin masana'antu daban-daban.
1. Gabatarwa zuwa Hydroxypropyl methylcellulhin (hpmc)
Hydroxypyl methylcellose ne mai narkewa ne na sel-roba na selulose. Ana samarwa ta hanyar musanyawa na sel tare da ƙungiyoyin hydroxypyl da ƙungiyoyin methyl. A rabo daga waɗannan saƙo na iya bambanta, jagorancin misalai daban-daban na HPMC tare da halaye daban-daban, gami da danko. Tsarin al'ada na HPMC ya ƙunshi fanfi na sel tare da hydroxypropyl da metyl ƙungiyoyi a haɗe zuwa rukunin glucose.
Ana amfani da HPMC a cikin masana'antu daban-daban saboda nazarin halittarsa, ikon samar da gels, da sauƙi na rashin daidaituwa a ruwa. A cikin mafita na ruwa mai narkewa, HPMC yana nuna halin da ba ionic, ruwa mai narkewa wanda ke da tasiri na kaddarorin ƙwararrun mafita, musamman danko.
2. Halayen HPROCH na Magani HPMC
Maganin Magana na HPMC yana rinjayi abubuwan da yawa, gami da maida hankali ga HPMC, nauyin kwayar halittar polymer, zazzabi, da kuma kasancewar salts ko wasu suyi. Da ke ƙasa akwai manyan abubuwan farko waɗanda ke mulkin halayen HPMC a cikin mafita:
Taro na HPMC: Vecchi Haihuwar yana ƙaruwa yayin da maida hankali ga HPMC yana ƙaruwa. A mafi girma maida hankali, kwayoyin HPMC suna da mahimmanci ga juna, suna kaiwa ga mafi yawan juriya zuwa gudana.
Yawan nauyin kwayar cutar kwayar cutar hpmc: Danko na hanyoyin hpmc mafi ƙarfi yana da ƙarfi sosai tare da nauyin kwayoyin na polymer. Mafi girma kwayoyin nauyi na hpmc maki don samar da mafita viscous. Wannan saboda manyan kwayoyin polymer suna haifar da ƙarin juriya ga gudummawa ga haɓakawa da kuma tashin hankali.
Ƙarfin zafi: Danko yana raguwa kamar yadda zafin jiki yake ƙaruwa. Wannan saboda mafi girman yanayin zafi yana haifar da rage sojojin da ke tsakaninsu tsakanin kwayoyin halittar HPMC, don haka rage ƙarfin su na tsayayya da gudana.
Ƙattai: Dankowar hanyoyin HPMC shine karfi na-dogaro, musamman a cikin ruwayen ruwa, wanda yake shine mafita na polymer. A low gwarzawar karfi, hpmc mafita yana nuna babban danko, yayin da a yawan masu tasoshi, danko ya ragu saboda halayen thinning.
Tasirin Ionic ƙarfi: Kasancewar wutan lantarki (kamar salts) a cikin maganin na iya canza danko. Wasu salts za su iya tallata wa sojojin shiga tsakanin sarƙoƙin polymer, suna sa su tara kuma wanda ya haifar da raguwa a cikin danko.
3. Kawasaki da Taro: Lura da Gwaji
Babban Trend lura a cikin gwaje-gwaje shine cewa dankalin turawa na HPMC mafita yana ƙaruwa da maida hankali tare da ƙara maida hankali ta polymer. Ana iya bayyana alaƙar da ke tsakanin danko da taro waɗanda ake amfani da su masu zuwa, wanda galibi ana amfani dashi don mafita na polymer:
η = Acn \ Eta = AC ^ NW = Acn
A ina:
η \ etarη shine danko
CCC shine maida hankali kan hpmc
Aaa da nnn sune masu ba da labari game da takamaiman nau'in HPMC da kuma yanayin mafita.
Don ƙananan taro, dangantakar tana da layi, amma kamar yadda maida hankali ke ƙaruwa, ganin karuwar yana ɗauka sosai, yana nuna haɓakar haɓakawa tsakanin sarƙoƙi na polymer.
4. Danko mai kyan gani
Nauyin kwayar halitta na kimacecellhpmc yana taka muhimmiyar rawa a cikin halaye na danko. Mafi girma ƙwayar ƙwayar ƙwayar ƙwayar cuta ta HPMC ta fi dacewa da mafita gaanan ƙwayoyin cuta idan aka kwatanta da ƙananan nauyin ƙwayoyin cuta. Maganin Magana da aka yi daga babban-ƙwayoyin cuta na HPMC na iya zama zuwa yawancin umarni da yawa fiye da na mafita da aka yi daga ƙananan ƙwayoyin cuta.
Misali, bayani na HPMC tare da nauyin kwayar halittar 100,000 Da kuma zai nuna girman karfi fiye da ɗaya tare da nauyin kwayar cuta na 50,000 Da kuma a daidai maida hankali.
5. Tasirin zazzabi a kan danko
Zazzabi yana da tasiri mai mahimmanci akan danko na mafita na HPMC. Theara yawan zafin jiki yana haifar da raguwa a cikin danko na Magani. Wannan shi ne da farko saboda motsi na ƙayyadaddun sarkar polymer, wanda ke haifar da su motsa mafi yardar rai, rage su ta gudana. Tasirin zafin jiki a kan danko ana kiranta amfani da daidaitaccen nau'in athenius:
η (t) = η0eearfin \ Etisa (t) = \ Etia_0 e ^ {{{{{{_a}
A ina:
η (t) \ Etisa (t) η (t) η (t) shine danko a yawan zafin jiki
η0 \ ETA_0GET0 shine mafi kyawun bayani (danko a zazzabi mara iyaka)
EAE_aea shine makamashi
RRR shine gas dindindin
Ttt shine cikakkiyar zazzabi
6. Dabi'ar rheolical
Ruhaniya na maganin hpmc ruwa sau da yawa ana yawan bayyana shi a matsayin wanda ba shi da Newctoniya ba, ma'ana danko. A low gwarzawar karfi, hpmc mafita yana nuna babban danko saboda mai shiga mai shiga cikin sarƙoƙi na polymer sarƙoƙi. Koyaya, kamar yadda adadin karfi ya ƙaru, danko ya ragu-wani sabon abu wanda aka sani da karfi Thinning.
Wannan halayyar thinning ta hali ne na mafita da yawa polymer mafita, ciki har da HPMC. Za a iya bayyana daddaɗaɗɗa Dogaro da danko mai amfani ta amfani da ƙirar iko:
(γ˙) kγ not} {s
A ina:
γ˙ ot {gamma} γ˙ Ita ce
KKK shine tsarin daidaito
NNN shine tsarin halayyar fasaha (tare da n <1n <1n <1n <1 don garken shanu)
7. Kwararrun Magana HPMC: Tebur Summary
Da ke ƙasa akwai tebur a teburin halayen kayan kwalliyar HPMC a ƙarƙashin yanayi daban-daban.
| Misali | Tasiri akan danko |
| Taro | Yana kara danko kamar yadda taro yake ƙaruwa |
| Nauyi na kwayoyin | Mafi girman nauyin kwaya yana kara danko |
| Ƙarfin zafi | Yana kara yawan zafin jiki ya rage danko |
| Ƙattai | Mafi girman karfi da rage danko (halayyar thinning hali) |
| Ionic karfi | Kasancewar salts na iya rage danko ta hanyar nuna goyon baya tsakanin sarƙoƙi polymer |
| Misali: danko na HPMC (2% w / v) bayani | Keta (CP) |
| Hpmc (low mw) | ~ 50-100 cp |
| Hpmc (matsakaici Mw) | ~ 500-1,000 cp |
| HPMC (High MW) | ~ 2,000-5,000 cp |
Halayen danko naHpmCMasu amfani da ruwa na ruwa suna rinjayar da yawancin abubuwan, gami da taro, nauyin kwayoyin, da kuma karfi. HPMC babban abu ne mai mahimmanci, kuma ana iya dacewa da kayan aikin rheological don takamaiman aikace-aikace ta hanyar daidaita waɗannan sigogi. Fahimtar wadannan dalilai suna ba da damar mafi kyawun amfani da Kimacecellomphpmc a cikin masana'antu daban-daban, daga magunguna ga abinci da kayan kwalliya. Ta hanyar yin amfani da yanayin da aka narkar da HPMC, masana'antun zasu iya cimma manufar da ake so da kuma kwararar kayan da ake buƙata don takamaiman bukatunsu.
Lokaci: Jan-27-2025