Hydroxypropyl methylcellulose sanannen polymer ne mai narkewa da ruwa wanda ke samar da ingantaccen bayani mai ƙarfi a cikin ruwa kuma ana amfani dashi ko'ina a cikin masana'antar harhada magunguna, abinci da gine-gine. Yana da albarkatun da ba na ionic cellulose ba wanda ke inganta haɗin kai da haɗin kai na samfurin ƙarshe. Domin tabbatar da babban ingancin aikin hydroxypropyl methylcellulose, samfurin yana buƙatar gwadawa da cancanta kafin amfani. A cikin wannan labarin, zamu tattauna hanyoyi guda uku masu dogara don gaya ingancin hydroxypropyl methylcellulose.
1. Gwajin danko
Dankowar hydroxypropyl methylcellulose wani muhimmin siga ne don sanin ingancinsa. Dankowa shine juriyar ruwa don gudana kuma ana auna shi a centipoise (cps) ko mPa.s. Dankin hydroxypropyl methylcellulose ya bambanta bisa ga nauyin kwayoyinsa da matakin maye gurbinsa. Mafi girman matakin maye gurbin, ƙananan danko na samfurin.
Don gwada danko na hydroxypropyl methylcellulose, narke ɗan ƙaramin adadin samfurin a cikin ruwa kuma yi amfani da viscometer don auna danko na maganin. Dankowar maganin yakamata ya kasance cikin kewayon da aka ba da shawarar wanda mai siyar da samfur ya bayar. Kyakkyawan ingancin hydroxypropyl methylcellulose samfurin yakamata ya kasance yana da daidaiton danko, wanda shine nunin tsafta da girman nau'in barbashi.
2. Gwajin maye gurbin
Matsayin maye yana nufin rabon adadin ƙungiyoyin hydroxyl akan cellulose wanda aka maye gurbinsu da ƙungiyoyin hydroxypropyl ko methyl. Matsayin musanya alama ce ta tsabtar samfur, mafi girman matakin maye gurbin, mafi kyawun samfurin. Ya kamata samfuran hydroxypropyl methylcellulose masu inganci su sami babban matsayi na maye gurbin.
Don gwada matakin maye gurbin, ana yin titration tare da sodium hydroxide da hydrochloric acid. Ƙayyade adadin sodium hydroxide da ake buƙata don kawar da hydroxypropyl methylcellulose kuma ƙididdige matakin maye gurbin ta amfani da dabara mai zuwa:
Digiri na Sauya = ([Murfin NaOH] x [Tsarin NaOH] x 162) / ([Nauyin Hydroxypropyl Methyl Cellulose] x 3)
Matsakaicin maye ya kamata ya kasance cikin kewayon shawarar da mai siyar da samfuran ya bayar. Matsayin maye gurbin samfuran hydroxypropyl methylcellulose masu inganci yakamata ya kasance cikin kewayon da aka ba da shawarar.
3. Gwajin narkewa
Solubility na hydroxypropyl methylcellulose wani mahimmin siga ne wanda ke ƙayyade ingancinsa. Ya kamata samfurin ya zama mai narkewa cikin sauƙi a cikin ruwa kuma kada ya zama lumps ko gels. Ya kamata samfuran hydroxypropyl methylcellulose masu inganci su narke da sauri kuma a ko'ina.
Don yin gwajin narkewa, narkar da ƙaramin adadin samfurin a cikin ruwa kuma motsa maganin har sai ya narkar da gaba ɗaya. Maganin ya kamata ya kasance a bayyane kuma ba tare da lumps ko gels ba. Idan samfurin bai narke cikin sauƙi ba ko kuma ya samar da lumps ko gels, yana iya zama alamar rashin inganci.
A ƙarshe, hydroxypropyl methylcellulose wani abu ne mai mahimmanci da ake amfani dashi a masana'antu daban-daban. Don tabbatar da ingancin samfurin, an yi danko, maye gurbin da gwajin solubility. Waɗannan gwaje-gwajen zasu taimaka don fahimtar halayen samfurin a sarari kuma suna taimakawa wajen rarrabe ingancinsa. High quality-hydroxypropyl methylcellulose yana da daidaitaccen danko, babban matsayi na maye gurbin, kuma yana narkewa da sauri kuma daidai a cikin ruwa.
Lokacin aikawa: Jul-11-2023