Hanyar samar da nutsewar alkaline hanya ce ta gama gari don samar da hydroxypropyl methyl cellulose (HPMC). Wannan hanya ta ƙunshi amsawar cellulose tare da sodium hydroxide (NaOH) sannan tare da propylene oxide (PO) da methyl chloride (MC) a ƙarƙashin wasu yanayi.
Hanyar nutsewar alkaline tana da fa'idar samar da HPMC tare da babban canji (DS), wanda ke ƙayyade kaddarorinsa kamar solubility, danko, da gelation. Hanyar ta ƙunshi matakai masu zuwa:
- Shiri na Cellulose
Ana samun cellulose daga tushen halitta kamar itace, auduga, ko wasu kayan shuka. An fara tsarkake cellulose sannan a bi da shi tare da NaOH don samar da sodium cellulose, wanda shine matsakaicin amsawa a cikin samar da HPMC.
- Maganin Sodium Cellulose tare da Propylene Oxide (PO)
Sa'an nan kuma ana mayar da sodium cellulose tare da PO a gaban mai kara kuzari kamar tetramethylammonium hydroxide (TMAH) ko sodium hydroxide (NaOH) a yanayin zafi da matsa lamba. Sakamakon sakamako yana haifar da samuwar hydroxypropyl cellulose (HPC).
- Halin HPC tare da Methyl Chloride (MC)
Ana mayar da HPC tare da MC a gaban mai kara kuzari kamar sodium hydroxide (NaOH) ko hydrochloric acid (HCl). Sakamakon sakamako a cikin samuwar hydroxypropyl methyl cellulose (HPMC).
- Wanka da bushewa
Bayan amsawa, ana wanke samfurin da ruwa kuma a bushe don samun HPMC. Yawanci ana tsarkake samfurin ta amfani da jerin matakan tacewa da centrifugation don cire duk wani ƙazanta.
Hanyar nutsewar alkaline tana da fa'idodi da yawa akan wasu hanyoyin, gami da babban DS da tsabta, ƙarancin farashi, da sauƙi mai sauƙi. Hakanan za'a iya amfani da hanyar don samar da HPMC tare da kaddarorin daban-daban ta hanyar bambanta yanayin halayen kamar zazzabi, matsa lamba, da maida hankali.
Duk da haka, hanyar kuma tana da wasu kurakurai. Yin amfani da NaOH da MC na iya haifar da aminci da haɗari na muhalli, kuma tsarin samarwa na iya zama mai cin lokaci kuma yana buƙatar makamashi mai yawa.
A ƙarshe, hanyar samar da nutsewar alkaline hanya ce da ake amfani da ita sosai don samar da HPMC. Hanyar ta ƙunshi amsawar cellulose tare da NaOH, PO, da MC a ƙarƙashin wasu yanayi, sannan tsarkakewa da bushewa. Yayin da hanyar tana da wasu kurakurai, fa'idodinta sun sa ya zama sanannen zaɓi don aikace-aikacen masana'antu da magunguna.
Lokacin aikawa: Afrilu-23-2023