Hydroxypropylmethylcellulose (HPMC) shine ether cellulose da ake amfani dashi sosai a masana'antu da yawa kamar su magunguna, kayan kwalliya, abinci, da gini. Saboda versatility da amfani kaddarorin, HPMC ya zama sanannen sinadari a daban-daban formulations. A halin yanzu, akwai nau'ikan HPMC da yawa akan kasuwa, kowanne yana da kaddarori da aikace-aikace na musamman.
HPMC shine polymer cellulose da aka gyara ta hanyar sinadarai da aka samu ta hanyar amsa cellulose tare da methyl chloride da propylene oxide. Wannan halayen yana gabatar da ƙungiyoyin methyl da hydroxypropyl a cikin tsarin cellulose, suna samar da ruwa mai narkewa, ba-ionic da polymer mai girma ba. Koyaya, nau'ikan HPMC daban-daban suna da digiri daban-daban na maye gurbin (DS) na ƙungiyoyin methyl da hydroxypropyl, waɗanda ke ƙayyade kaddarorinsu na zahiri da sinadarai.
Gabaɗaya, samfuran HPMC ana rarraba su gwargwadon danko da ƙimar DS. Danko wani muhimmin kaddarorin HPMC ne kamar yadda yake shafar solubility na samfurin, ikon yin fim da ikon yin kauri. A gefe guda, ƙimar DS tana ƙayyade matakin maye gurbin polymer kuma don haka matakin hydrophobicity na nau'in HPMC. Saboda haka, ana samun nau'ikan HPMC daban-daban ta hanyar bambancin ɗanko da ƙimar DS. A ƙasa akwai nau'ikan HPMC da aka fi sani da kuma yadda suka bambanta.
1. HPMC na yau da kullun
HPMC na gama gari yana da methyl DS daga 0.8 zuwa 2.0 da hydroxypropyl DS daga 0.05 zuwa 0.3. Irin wannan nau'in HPMC yana samuwa a cikin kewayon makin danko daga 3cps zuwa 200,000cps. Common sa HPMC yana da kyau solubility a cikin ruwa da Forms bayyanannu mafita, sa shi dace da daban-daban aikace-aikace a cikin abinci, Pharmaceutical da kuma kwaskwarima masana'antu. Irin waɗannan HPMCs ana amfani da su azaman tsofaffin fina-finai, masu kauri, emulsifiers da stabilizers a abinci da kayan kwalliya.
2. Low maye gurbin HPMC
Ƙananan maye gurbin HPMC yana da ƙananan digiri na methyl da hydroxypropyl maye gurbin fiye da na HPMC na yau da kullum. Wannan nau'in HPMC na musamman yana da methyl DS daga 0.2 zuwa 1.5 da hydroxypropyl DS daga 0.01 zuwa 0.2. Ƙananan maye gurbin samfuran HPMC suna da ƙananan danko, yawanci tsakanin 3-400cps, kuma suna da juriya ga gishiri da enzymes. Waɗannan kaddarorin suna yin ƙaramin maye gurbin HPMC wanda ya dace da samfuran abinci kamar kiwo, gidan burodi da samfuran nama. Bugu da ƙari, ƙananan maye gurbin HPMC ana kuma amfani da shi azaman mai ɗaure, rarrabuwa da wakili mai suturar kwamfutar hannu a cikin masana'antar harhada magunguna.
3. Babban maye gurbin HPMC
Babban mataki na maye gurbin HPMC yana da matsayi mafi girma na maye gurbin methyl da hydroxypropyl fiye da sa HPMC na yau da kullun. Wannan nau'in HPMC yana da methyl DS daga 1.5 zuwa 2.5 da kuma hydroxypropyl DS daga 0.1 zuwa 0.5. Samfuran HPMC da aka musanya sosai suna da ɗanko mafi girma, kama daga 100,000cps zuwa 200,000cps, kuma suna da ƙaƙƙarfan kaddarorin riƙe ruwa. Waɗannan kaddarorin sun sanya HPMC da aka maye gurbinsu da kyau don amfani a ɓangaren gini, kamar samfuran tushen siminti, sutura da mannewa. Hakanan ana amfani da HPMC da aka musanya sosai azaman ɗaure, mai kauri da wakili na saki a cikin masana'antar harhada magunguna.
4. Methoxy-Ethoxy HPMC
Methoxy-Ethoxy HPMC wani nau'in HPMC ne na musamman da aka ƙera tare da babban matakin maye gurbin ethoxy. Ƙungiyoyin ethoxy suna haɓaka hydrophobicity na HPMC, suna mai da shi ƙasa mai narkewa a cikin ruwa fiye da sa HPMC na yau da kullum. Tare da methyl DS daga 1.5 zuwa 2.5 da kuma ethoxy DS daga 0.4 zuwa 1.2, methoxy-ethoxy HPMC ya dace don amfani a cikin samfuran tushen mai kamar kayan shafawa, fenti da sutura. Irin wannan nau'in HPMC yana samar da fim mai tsayi da daidaito wanda ke ba da santsi, mai kyalli zuwa samfurin ƙarshe.
5. Granular HPMC
Granular HPMC wani nau'in HPMC ne wanda ke da ƙaramin ƙarami, yawanci tsakanin 100-200 microns. Ana amfani da HPMC na granular a cikin masana'antar harhada magunguna azaman mai ɗaure kwamfutar hannu, rarrabuwar kawuna da wakili mai dorewa. The kananan barbashi size of HPMC barbashi damar don wani ko da rarraba sinadaran, sakamakon a m da kuma abin dogara samfurin. Granular HPMC yana da methyl DS daga 0.7 zuwa 1.6 da hydroxypropyl DS daga 0.1 zuwa 0.3.
Hydroxypropylmethylcellulose (HPMC) polymer ne mai aiki da yawa tare da aikace-aikace da yawa a masana'antu daban-daban. Ana rarraba nau'ikan HPMC bisa ga danko da ƙimar DS, waɗanda ke ƙayyadaddun kaddarorinsu na zahiri da sinadarai. HPMC na yau da kullun, ƙaramin canji HPMC, babban maye gurbin HPMC, methoxyethoxy HPMC da granular HPMC sune mafi yawan nau'ikan HPMC. Fahimtar bambance-bambancen da ke tsakanin waɗannan nau'ikan zai ba da damar masu ƙira su yi amfani da cikakkiyar damar HPMC don samar da ingantattun samfuran ƙarshe da inganci.
Lokacin aikawa: Satumba-06-2023