Ta yaya ake samar da Hydroxypropyl Methylcellulose (HPMC)?

Hydroxypropyl methylcellulose (HPMC) polymer ce mai narkewar ruwa mai narkewa da aka saba amfani da ita a masana'antar harhada magunguna, gini da masana'antar abinci, da sauransu. An samo shi daga cellulose, wani polymer na halitta wanda aka samo a cikin ganuwar kwayoyin halitta. Mai zuwa shine cikakken bayyani na tsarin samar da HPMC:

Tushen cellulose:

Babban kayan da ake samarwa na HPMC shine cellulose, wanda za'a iya samuwa daga ɓangaren litattafan katako ko auduga. Bangaran itace tushen gama gari ne saboda yana da yawa kuma yana da tsada.

Maganin Alkali:

Ana kula da cellulose tare da alkali (yawanci sodium hydroxide) don cire datti da hemicellulose. Wannan tsari, wanda ake kira mercerization, yana samar da cellulose mai tsabta.

Etherification:

Sa'an nan kuma tsarkakewar cellulose yana ƙarƙashin etherification, wani nau'i na sinadaran da ke gabatar da ƙungiyoyin ether a cikin kashin baya na cellulose. Ga HPMC, duka hydroxypropyl da ƙungiyoyin methyl an gabatar da su a kan kwayar halitta ta cellulose.

Hydroxypropylation:

Ana amfani da propylene oxide don shigar da ƙungiyoyin hydroxypropyl cikin cellulose. Wannan mataki ya ƙunshi amsawar propylene oxide da cellulose a gaban mai kara kuzari.

Methylation:

An gabatar da ƙungiyoyin methyl a cikin cellulose hydroxypropylated ta amfani da methyl chloride ko dimethyl sulfate. Ana kiran wannan mataki methylation.

Neutralizing da wankewa:

Bayan amsawar etherification, samfur ɗin yana dakushe don cire duk wani tushe da ya rage. Ana wanke sakamakon HPMC da aka samu don cire kayan aiki da sinadarai marasa ƙarfi.

bushewa:

Mataki na ƙarshe ya haɗa da bushewar HPMC don cire ruwa mai yawa da samun samfurin da ake so a cikin foda ko granular form.

Yana da mahimmanci a lura cewa ƙayyadaddun cikakkun bayanai na tsarin samarwa na iya bambanta tsakanin masana'antun, kuma suna iya amfani da yanayi daban-daban, masu haɓakawa, da reagents don cimma aikin da ake so na HPMC. Bugu da ƙari, ana aiwatar da matakan kula da inganci a duk tsawon aikin samarwa don tabbatar da daidaito da tsabtar samfurin ƙarshe.