Abubuwan da ke shafar danko na hydroxypropyl methylcellulose

Hydroxyl methyl cellulose (HPMC) polymer ne da aka yi amfani da shi sosai a cikin magunguna, kayan shafawa, abinci da sauran masana'antu. Siffofin sa na musamman, irin su babban danko, ruwa mai kyau - mai narkewa da ikon samuwar membrane, yana mai da shi muhimmin sashi a cikin dabaru daban-daban. Danko shine mabuɗin fasalin HPMC a aikace-aikacen sa. Dankowar HPMC yana shafar abubuwa daban-daban, kamar maida hankali, zafin jiki, pH, da nauyin kwayoyin halitta. Fahimtar abubuwan da ke shafar dankowar HPMC yana da mahimmanci don haɓakawa. Wannan labarin ya tattauna abubuwan da suka shafi danko na hydroxylopyl methyl cellulose.

Mai da hankali kan

Ƙaddamarwar HPMC yana ɗaya daga cikin mahimman abubuwan da ke shafar danko. Dankowar maganin HPMC yana ƙaruwa tare da haɓaka haɓaka. A ƙananan maida hankali, sarkar polymer na HPMC yana warwatse a cikin sauran ƙarfi, don haka danko yana da ƙasa. Duk da haka, a matsayi mafi girma, sarkar polymer yana kula da hulɗa da juna, yana haifar da danko mafi girma. Sabili da haka, danko na HPMC yana daidai da ƙaddamarwar polymer. Har ila yau, maida hankali yana rinjayar halayen gelization na HPMC. High-concentration HPMC iya samar da gel, wanda yake da matukar muhimmanci a cikin Pharmaceutical da abinci masana'antu.

zafin jiki

Zazzabi wani maɓalli ne mai mahimmanci wanda ke shafar danko na hydroxylopenyl cellulose. Dankowar HPMC yana raguwa tare da karuwar zafin jiki. Sarkar polymer na HPMC ya zama mafi gudana a mafi girman zafin jiki, yana haifar da ƙananan danko. Idan aka kwatanta da babban taro mafita, sakamakon zafin jiki a kan HPMC danko ne mafi fili a cikin low taro bayani. Ƙara yawan zafin jiki kuma zai shafi solubility na HPMC. A mafi girman zafin jiki, solubility na HPMC yana raguwa, yana haifar da raguwa a cikin danko wanda ya haifar da raguwa a cikin sarkar sarkar.

pH

A pH na HPMC bayani wani muhimmin al'amari ne da ke shafar danko. HPMC polymer mai rauni ce mai rauni, tare da PKA kusan 3.5. Sabili da haka, danko na maganin HPMC yana kula da pH na maganin. A ƙarƙashin ƙimar pH sama da PKA, rukunin gishiri na carboxylic acid na polymer ya kasance ƙarƙashin protonization, wanda ya haifar da solubility na HPMC ya karu, kuma an rage danko saboda raguwar haɗin hydrogen na interconsiscence na ƙwayoyin cuta. Ƙarƙashin ƙimar pH da ke ƙasa PKA, ƙungiyar carboxylic acid na polymer ya kasance mai yawa, wanda ya haifar da ƙananan solubility da babban danko wanda ya haifar da karuwar hydrogen bond. Sabili da haka, mafi kyawun ƙimar pH na maganin HPMC ya dogara da aikace-aikacen da ake tsammani.

Nauyin kwayoyin halitta

Nauyin kwayoyin halitta na HPMC wani muhimmin al'amari ne wanda ke shafar dankon sa. HPMC shine polymer polymer. Yayin da nauyin kwayoyin halitta na polymer ya karu, danko na maganin HPMC zai karu. Wannan saboda sarkar HPMC mai nauyin nauyin kwayoyin halitta ta fi hadewa, yana haifar da karuwar danko. Nauyin kwayoyin halitta na polymer kuma yana shafar gelization na HPMC. HPMC polymer yana da yuwuwar samar da gels fiye da ƙananan nau'ikan polymers.

Gishiri

Ƙara gishiri zuwa maganin HPMC na iya tasiri sosai ga danko. Gishiri yana rinjayar ƙarfin ion na maganin HPMC, wanda ke canza hulɗar polymers. Gabaɗaya, ƙara gishiri zuwa maganin HPMC zai sa danko ya ragu. Wannan shi ne saboda ƙarfin ion na maganin yana raguwa tsakanin ƙarfin kwayoyin halitta tsakanin sarkar polymer na HPMC, don haka rage raguwar sarkar sarkar, don haka an rage danko. Tasirin gishiri akan dankowar maganin HPMC ya dogara da nau'in gishiri da taro.

a karshe

Dankowar hydroxydal cibolin shine maɓalli mai mahimmanci wanda ke shafar aikace-aikacen sa a masana'antu daban-daban. Abubuwan da ke shafar dankowar HPMC sun haɗa da maida hankali, zafin jiki, pH, nauyin kwayoyin halitta da gishiri. Fahimtar waɗannan abubuwan akan danko na HPMC yana da mahimmanci don haɓaka amfani da shi a aikace-aikace daban-daban. Maganin HPMC za a iya gyara shi da kyau don cimma maƙasudin da ake buƙata wanda ke da takamaiman.