Hydroxypropyl methylcellulose (HPMC) wani fili ne na polymer mai narkewa da ruwa wanda aka yi amfani da shi sosai a magani, abinci, kayan gini da sauran fannoni. Saboda da kyau thickening, film-forming, emulsifying, bonding da sauran kaddarorin, shi ne yadu amfani a matsayin thickener, stabilizer da suspending wakili. Abubuwan rheological na HPMC, musamman aikin sa a yanayin zafi daban-daban, abubuwa ne masu mahimmanci waɗanda ke shafar tasirin aikace-aikacen sa.
1. Bayani na HPMC Rheological Properties
Rheological Properties ne mai cikakken tunani na nakasawa da kwarara halaye na kayan a karkashin waje sojojin. Don kayan polymer, danko da halayen ɓacin rai sune mafi yawan sigogin rheological guda biyu. The rheological Properties na HPMC an yafi shafa da dalilai kamar kwayoyin nauyi, maida hankali, ƙarfi Properties da zafin jiki. A matsayin ether wanda ba na ionic cellulose ba, HPMC yana nuna pseudoplasticity a cikin maganin ruwa, wato, dankon sa yana raguwa tare da karuwa mai girma.
2. Tasirin Zazzabi akan Viscosity na HPMC
Zazzabi yana ɗaya daga cikin mahimman abubuwan da ke shafar kaddarorin rheological na HPMC. Yayin da zafin jiki ya ƙaru, dankowar maganin HPMC yawanci yana raguwa. Wannan shi ne saboda karuwar zafin jiki yana raunana hulɗar haɗin gwiwar hydrogen tsakanin kwayoyin ruwa, ta yadda za a rage karfin hulɗar tsakanin sarƙoƙin kwayoyin halitta na HPMC, yana sa sassan kwayoyin suna da sauƙi don zamewa da gudana. Saboda haka, a yanayin zafi mafi girma, HPMC mafita suna nuna ƙananan danko.
Koyaya, canjin danko na HPMC ba alakar layi ba ce. Lokacin da zafin jiki ya tashi zuwa wani ɗan lokaci, HPMC na iya fuskantar tsarin rushewar hazo. Ga HPMC, dangantakar dake tsakanin solubility da zafin jiki ya fi rikitarwa: a cikin wani nau'i na zafin jiki, HPMC za ta yi hazo daga maganin, wanda aka bayyana a matsayin karuwa mai girma a cikin danko bayani ko samuwar gel. Wannan al'amari yawanci yana faruwa ne lokacin da ya kusanci ko ya wuce zafin narkar da HPMC.
3. Sakamakon zafin jiki akan halayen rheological na maganin HPMC
Halin rheological na maganin HPMC yawanci yana nuna tasiri mai laushi, wato, danko yana raguwa lokacin da adadin kuzari ya karu. Canje-canje a cikin zafin jiki yana da tasiri mai mahimmanci akan wannan tasiri mai laushi. Gabaɗaya, yayin da zafin jiki ya ƙaru, danƙowar maganin HPMC yana raguwa, kuma tasirin sa mai ƙarfi yana ƙara fitowa fili. Wannan yana nufin cewa a yanayin zafi mai zafi, danko na maganin HPMC ya zama mafi dogara ga ƙimar shear, watau, a daidai wannan adadin, maganin HPMC a babban zafin jiki yana gudana cikin sauƙi fiye da ƙananan zafin jiki.
Bugu da ƙari, haɓakar zafin jiki kuma yana rinjayar thixotropy na maganin HPMC. Thixotropy yana nufin kadarorin da danko na wani bayani ya ragu a ƙarƙashin aikin karfi mai karfi, kuma danko a hankali ya dawo bayan an cire karfi. Gabaɗaya, haɓakar zafin jiki yana haifar da karuwa a cikin thixotropy na maganin HPMC, watau, bayan an cire ƙarfin ƙarfi, danko yana dawowa sannu a hankali fiye da yanayin ƙarancin zafin jiki.
4. Sakamakon zafin jiki akan halayen gelation na HPMC
HPMC yana da keɓantaccen kayan gelation na thermal, watau, bayan dumama zuwa wani zazzabi (gel zafin jiki), maganin HPMC zai canza daga yanayin bayani zuwa yanayin gel. Wannan tsari yana tasiri sosai ta yanayin zafi. Yayin da zafin jiki ya karu, hulɗar tsakanin hydroxypropyl da methyl madogara a cikin kwayoyin HPMC yana ƙaruwa, wanda ya haifar da haɗuwa da sassan kwayoyin halitta, ta haka ne ya samar da gel. Wannan al'amari yana da mahimmanci a cikin masana'antar harhada magunguna da abinci saboda ana iya amfani dashi don daidaita yanayin rubutu da sakin kayan samfur.
5. Aikace-aikace da mahimmancin aiki
Tasirin zafin jiki akan abubuwan rheological na HPMC yana da mahimmanci a aikace-aikace masu amfani. Don aikace-aikacen mafita na HPMC, kamar shirye-shiryen ci gaba-saki na miyagun ƙwayoyi, masu kauri na abinci, ko masu kula da kayan gini, dole ne a yi la'akari da tasirin zafin jiki akan kaddarorin rheological don tabbatar da kwanciyar hankali da aikin samfur ɗin ƙarƙashin yanayin yanayin zafi daban-daban. Misali, lokacin shirya magunguna masu zafi, tasirin canjin zafin jiki akan danko da halayen gelation na matrix na HPMC yana buƙatar la'akari don haɓaka ƙimar sakin miyagun ƙwayoyi.
Zazzabi yana da tasiri mai mahimmanci akan abubuwan rheological na hydroxypropyl methylcellulose. Ƙara yawan zafin jiki yawanci yana rage danko na mafita na HPMC, yana haɓaka tasirin sa mai ƙarfi da thixotropy, kuma yana iya haifar da gelation thermal. A aikace-aikace masu amfani, fahimta da sarrafa tasirin zafin jiki akan kaddarorin rheological na HPMC shine mabuɗin don haɓaka aikin samfur da sigogin tsari.
Lokacin aikawa: Satumba-05-2024