Hlobo luni lwe-polymer i-HPMC?

I-HPMC, noma i-hydroxypropyl methylcellulose, iwuhlobo lwe-polymer esekwe ku-cellulose esetshenziswa kakhulu embonini yezemithi, yokudla, neyokunakekelwa komuntu siqu. I-Cellulose iyi-polymer yemvelo etholakala ezitshalweni futhi iyinhlanganisela yezinto eziphilayo egcwele kakhulu emhlabeni. Kuyi-polymer eqondile eyenziwe ngama-glucose monomers axhunywe ngamabhondi e-β(1→4) e-glycosidic.

I-HPMC ikhiqizwa i-cellulose eshintsha amakhemikhali ngamaqembu e-methyl noma e-hydroxypropyl. Lezi zinguquko zingenziwa ngokuphendula i-cellulose nama-reagents afanelekile phambi kwe-catalyst ye-asidi. Ukusabela phakathi kwe-cellulose ne-methyl chloride noma i-methyl bromide kukhiqiza i-methylcellulose, kuyilapho ukusabela phakathi kwe-cellulose ne-propylene oxide kuveza i-hydroxypropyl cellulose. I-HPMC ikhiqizwa ngokuhlanganisa lokhu kusabela okubili ukwethula womabili amaqembu e-methyl kanye ne-hydroxypropyl kumgogodla we-cellulose.

I-polymer ewumphumela inesakhiwo esiyinkimbinkimbi esingahlukahluka kuye ngezinga lokushintshwa (DS) lamaqembu e-methyl kanye ne-hydroxypropyl. I-DS ibhekisela enanini elimaphakathi lamaqembu e-hydroxyl afakwe esikhundleni ngeyunithi ngayinye ye-anhydroglucose kumgogodla we-cellulose. Ngokuvamile, i-HPMC ine-DS engu-1.2 kuya ku-2.5 yamaqembu e-methyl kanye no-0.1 kuya ku-0.3 yamaqembu e-hydroxypropyl. Isakhiwo se-HPMC senziwa futhi sibe nzima yiqiniso lokuthi amaqembu e-methyl kanye ne-hydroxypropyl angasatshalaliswa ngokungahleliwe eduze komgogodla we-cellulose, okuholela ku-polymer ehlukahlukene enezinhlobonhlobo zezakhiwo.

I-HPMC iyi-polymer encibilika emanzini eyenza into efana nejeli lapho ifakwe amanzi. Izakhiwo ze-gelation ze-HPMC zincike ezintweni eziningi, okuhlanganisa i-DS, isisindo samangqamuzana, kanye nokugxila kwe-polymer. Ngokuvamile, i-HPMC yenza ijeli ezinzile ekugxiliseni okuphezulu kanye namanani aphezulu e-DS. Ngaphezu kwalokho, izakhiwo ze-gelation ze-HPMC zingathonywa i-pH, amandla e-ionic, kanye nezinga lokushisa lesixazululo.

Izakhiwo ezihlukile ze-HPMC ziyenza ibe isithako esibalulekile ezinhlelweni eziningi. Embonini yezemithi, i-HPMC isetshenziswa njenge-binder, disintegrant, kanye ne-ejenti yokwakha ifilimu kumaphilisi namaphilisi. Ingase futhi isetshenziselwe ukuguqula izinga lokukhululwa kwezidakamizwa efomini lomthamo. Embonini yokudla, i-HPMC isetshenziswa njenge-thickener, stabilizer, kanye ne-emulsifier. Kuvame ukusetshenziswa ekudleni okunamafutha aphansi noma okuncishisiwe ukulingisa ukuthungwa nokuzwakala komlomo kokudla okunamafutha aphezulu. Embonini yokunakekelwa komuntu siqu, i-HPMC isetshenziswa njenge-thickener, i-ejenti yokwakha ifilimu, kanye ne-emulsifier kuma-shampoos, okokugcoba, neminye imikhiqizo.

Sengiphetha, i-HPMC iyi-polymer esekwe ku-cellulose ekhiqizwa i-cellulose eshintsha amakhemikhali ngamaqembu e-methyl kanye ne-hydroxypropyl. I-polymer ewumphumela iyancibilika emanzini futhi inesakhiwo esiyinkimbinkimbi esingahlukahluka kuye ngezinga lokushintshwa kanye nokusatshalaliswa kwamaqembu e-methyl kanye ne-hydroxypropyl. I-HPMC iyi-polymer enemisebenzi eminingi embonini yezemithi, yokudla, neyokunakekelwa komuntu siqu.