Ikotini elicwengekileyo-ukuvula-alkalization-etherification-neutralization-separation-washing-separation-drying-crushing-packaging-kuqedile ukuvulwa komkhiqizo we-HPMC: Ikotini elicwengekile livulwa ukukhipha insimbi bese lichotshozwa. Ukotini ocolisisiwe ohlungiwe usesimweni sempushana, enosayizi wezinhlayiyana ezingama-80 mesh kanye nokudluliswa kwe-100%. Uma kungenjalo, kulula ukuhlangana ndawonye ngesikhathi senqubo yokusabela futhi kunciphise ukusebenza kahle kwe-etherification.
I-Alkalization: Engeza ukotini ocolisisiwe oyimpuphu ngemva kokuvuleka kukakotini kusincibilikisi esingasebenzi, bese usenza sisebenze nge-alkali namanzi athambile ukuze uvuvuke i-lattice kakotini ocolile ukuze kube lula ukungena kwama-molecule e-etherification futhi uthuthukise ukufana kokusabela kwe-etherification. I-alkali esetshenziselwa i-alkalization i-hydroxide yensimbi noma i-alkali ephilayo. Inani le-alkali elingeziwe (ngobuningi, okufanayo ngezansi) liphindwe izikhathi ezingu-0.1-0.6 zekotini elicwengekile, inani lamanzi athambile angeziwe liphindwe izikhathi ezingu-0.3-1.0 kunekotini elicwengekile; i-solvent ye-inert iyinhlanganisela yotshwala ne-hydrocarbon, futhi inani le-solvent ye-inert eyengeziwe liphindwe izikhathi ezingu-0.3-1.0 kunekotini elicwengekile. Izikhathi ezingu-7 -15 zalokho: I-solvent ye-inert ingaba futhi utshwala obunama-athomu e-carbon angu-3-5 (njengotshwala, i-propanol), i-acetone. Kungaba futhi i-aliphatic hydrocarbons nama-hydrocarbon anephunga elimnandi; izinga lokushisa kufanele lilawulwe ngaphakathi kwe-0-35 ° C ngesikhathi se-alkalization; isikhathi se-alkalization cishe ihora elingu-1. Ukulungiswa kwezinga lokushisa nesikhathi kunganqunywa ngokuya ngezinto ezibonakalayo nezidingo zomkhiqizo.
I-Etherification: Ngemva kokwelashwa kwe-alkalization, ngaphansi kwezimo ze-vacuum, i-etherification agent iyengezwa ukuze i-etherification, futhi i-etherification agent yi-propylene oxide. Ukuze kuncishiswe ukusetshenziswa kwe-etherification ejenti, ngesikhathi senqubo ye-etherification, i-etherification ejenti yengezwa izikhathi ezimbili, inani lokwengezwa kokuqala liphindwe izikhathi ezingu-1-3.5 kunekotini elicwengekile, futhi inani eliphelele lalezi zinto ezimbili ezingeziwe ziyi-1.5 -4 izikhathi zikakotini ocolisisiwe. izikhathi. Ngemuva kokufaka i-ejenti etherifying okokuqala, gxuma ku-≤30 ° C ku-45min-90min, bese uphakamisa izinga lokushisa libe ngu-50-100 ° C ukuze uthole i-etherification ye-1-5h, bese upholisa ku-≤30 ° C, okwesibili. ukwengeza i-etherification eshukumisayo, isikhathi esishukumisayo singama-30-120min, bese sishiswa ukuze? ? ? Yenza i-etherification, isikhathi ngu-1-4h, ngalesi sikhathi, ukotini ocolisisiwe uhlangana ngokugcwele ne-etherification agent ukuze ukhiqize i-hYDROXYPROPYL METHYLCELLULOSE HPMC.
Ukuchotshozwa nokupakishwa: ukuchotshozwa nokusefa umkhiqizo omisiwe wokusungulwa kwamanje, usayizi wezinhlayiyana zomkhiqizo we-HPMC wokusungulwa kwamanje ngemva kokuchotshozwa nokusefa yi-40 mesh futhi ukudlulisa kungu-10096, noma ngokwezidingo zomsebenzisi. Bese upakisha i-HPMC.
Isikhathi sokuthumela: Nov-24-2022