I-Methyl cellulose (MC) kanye ne-hydroxypropyl methyl cellulose (HPMC) yizinto ezimbili eziphuma ku-cellulose ezisetshenziswa kakhulu embonini, ekwakhiweni, kwezemithi, ekudleni nakweminye imikhakha. Nakuba zifana ngesakhiwo, zinezakhiwo ezihlukene futhi Kunomehluko omkhulu ekusetshenzisweni nasekusetshenzisweni kwezinqubo zokukhiqiza.
1. Umehluko ekwakhekeni kwamakhemikhali
I-Methylcellulose (MC) kanye ne-hydroxypropylmethylcellulose (HPMC) zombili zithathwe ku-cellulose yemvelo futhi zingamakhemikhali e-cellulose ether eguqulwa ngamakhemikhali. Kodwa umehluko wabo ikakhulukazi usehlotsheni kanye nenani lamaqembu angena esikhundleni.
I-Methyl cellulose (MC)
I-MC ikhiqizwa ngokufaka amaqembu e-methyl esikhundleni samaqembu e-hydroxyl ku-cellulose (okungukuthi -OCH₃). Isakhiwo samakhemikhali se-MC ikakhulukazi siqukethe amaqembu athatha indawo ye-methyl ochungechungeni oluyinhloko lwe-cellulose, futhi izinga lokushintshwa kwalo lithinta ukunyibilika kwayo nezakhiwo. I-MC ivamise ukuncibilika emanzini abandayo kodwa hhayi emanzini ashisayo.
I-Hydroxypropyl methylcellulose (HPMC)
I-HPMC iphinde ilungiswe ngesisekelo se-methylcellulose, ngokufaka ingxenye yamaqembu e-hydroxyl esikhundleni se-methyl (-CH₃) ne-hydroxypropyl (-CH₂CH(OH)CH₃). Uma kuqhathaniswa ne-MC, ukwakheka kwamangqamuzana e-HPMC kuyinkimbinkimbi kakhulu, i-hydrophilicity yayo kanye ne-hydrophobicity ilingana kahle, futhi ingancibilika emanzini abandayo nashisayo.
2. Umehluko ekuncibilikeni kwezakhiwo zomzimba namakhemikhali
MC: I-Methylcellulose ngokuvamile inokunyibilika okuhle emanzini abandayo, kodwa izokwakha ijeli lapho izinga lokushisa likhuphuka. Emanzini ashisayo, i-MC ayincibiliki, yakha ijeli eshisayo.
I-HPMC: I-Hydroxypropyl methylcellulose ingancibilika ngokufanayo emanzini abandayo nashisayo, inebanga lokushisa elibanzi lokuncibilika, futhi ukunyibilika kwayo kuzinzile kune-MC.
Ukugeleza kwe-thermal
I-MC: I-MC inezakhiwo eziqinile ze-thermal gelling. Lapho izinga lokushisa likhuphukela ezingeni elithile, lizokwenza ijeli futhi lilahlekelwe ukunyibilika kwalo. Lesi sici siyenza ibe nokusetshenziswa okukhethekile embonini yokwakha neyokwenza imithi.
I-HPMC: I-HPMC iphinde ibe nezindawo ezithile zokushisa ezishisayo, kodwa izinga lokushisa layo lokwakheka kwejeli liphezulu futhi isivinini sokwakheka kwejeli siyahamba kancane. Uma kuqhathaniswa ne-MC, izakhiwo zejeli ezishisayo ze-HPMC ziyalawuleka futhi ngenxa yalokho zinenzuzo kakhulu ezinhlelweni ezidinga ukuzinza okuphezulu kwezinga lokushisa.
Umsebenzi ongaphezulu
I-MC: I-MC inomsebenzi ophansi ophansi. Nakuba ingasetshenziswa njenge-emulsifier ethile noma ukuqina kwezinye izinhlelo zokusebenza, umphumela awubalulekile njenge-HPMC.
I-HPMC: I-HPMC inomsebenzi ongaphezulu oqinile, ikakhulukazi ukwethulwa kweqembu le-hydroxypropyl, okwenza kube lula ukuhlanganisa, ukumisa okwesikhashana kanye nokujiya esixazululweni. Ngakho-ke, isetshenziswa kabanzi njengesengezo embotsheni nasezintweni zokwakha.
Ukubekezelela usawoti kanye nokuzinza kwe-pH
MC: I-Methylcellulose ayinakubekezelela usawoti okungekuhle futhi ijwayele ukuna ezindaweni ezinosawoti omningi. Inozinzo olumpofu ezindaweni ezine-asidi ne-alkali futhi ithintwa kalula inani le-pH.
I-HPMC: Ngenxa yokuba khona kwe-hydroxypropyl esikhundleni, ukubekezelela usawoti kwe-HPMC kungcono kakhulu kune-MC, futhi kungagcina ukuncibilika okuhle nokuzinza ebangeni le-pH elibanzi, ngakho-ke ifanele indawo yamakhemikhali ahlukahlukene.
3. Umehluko ezinqubweni zokukhiqiza
Ukukhiqizwa kwe-MC
I-Methylcellulose ikhiqizwa ngokusabela kwe-methylation ye-cellulose, imvamisa isebenzisa i-methyl chloride ukuze isabele nge-alkaline cellulose ukuze ithathele amaqembu e-hydroxyl kuma-molecule e-cellulose. Le nqubo idinga ukulawula izimo zokusabela ukuze kuqinisekiswe izinga elifanele lokushintsha, elithinta ukuncibilika nezinye izici ze-physicochemical zomkhiqizo wokugcina.
Ukukhiqizwa kwe-HPMC
Ukukhiqizwa kwe-HPMC kusekelwe ku-methylation futhi kunezela ukusabela kwe-hydroxypropylation. Okusho ukuthi, ngemva kokusabela kwe-methylation ye-methyl chloride, i-propylene oxide isabela ne-cellulose ukuze ikhiqize enye indawo ye-hydroxypropyl. Ukwethulwa kweqembu le-hydroxypropyl kuthuthukisa ukunyibilika kanye nekhono lokugeleza kwe-HPMC, okwenza inqubo yayo yokukhiqiza ibe nzima kakhulu futhi ibize kakhulu kune-MC.
4. Umehluko emikhakheni yezicelo
Inkambu yezinto zokwakha
I-MC: I-MC ivame ukusetshenziswa ezintweni zokwakha, ikakhulukazi njenge-thickener, i-ejenti yokugcina amanzi kanye ne-adhesive kudaka olomile kanye ne-putty powder. Kodwa-ke, ngenxa yezakhiwo zayo ze-thermal gelling, i-MC ingase yehluleke ezindaweni ezinokushisa okuphezulu.
I-HPMC: I-HPMC isetshenziswa kabanzi emkhakheni wokwakha. Ngenxa yokuthi iphinde ibe nokuzinza okuhle ezindaweni zokushisa okuphezulu, ifaneleka kakhulu ezimweni ezidinga ukubekezelela izinga lokushisa eliphakeme, njengama-adhesives amathayili, ama-insulation mortars kanye nephansi elizilinganisa. .
Izinkambu zemithi nokudla
I-MC: I-Methylcellulose ivame ukusetshenziswa njenge-disintegrant kanye ne-thickener kumaphilisi emalungiselelweni emithi. Ibuye isetshenziswe kokunye ukudla njenge-thickener ne-fiber supplement.
I-HPMC: I-HPMC inezinzuzo eziningi emkhakheni wezokwelapha. Ngenxa yokuncibilika kwayo okuzinzile nokuvumelana okuhle kwe-biocompatibility, ivamise ukusetshenziswa ezintweni zefilimu ezikhishwa isikhathi eside namagobolondo ama-capsule ezidakamizwa. Ngaphezu kwalokho, i-HPMC isetshenziswa kabanzi embonini yokudla, ikakhulukazi ekwenzeni amaphilisi emifino.
Umkhakha wezingubo zokugqoka nopende
I-MC: I-MC inemiphumela engcono yokujiya nokwenza ifilimu, kodwa amandla ayo okulungisa ukuzinza kanye ne-viscosity esixazululweni awalungile njenge-HPMC.
I-HPMC: I-HPMC isetshenziswa kakhulu embonini kapende nopende ngenxa yokujiya kwayo okuhle kakhulu, i-emulsification kanye nezakhiwo zefilimu, ikakhulukazi njenge-ejenti yokuqina kanye ne-leveling emigqonyeni esekwe emanzini, engathuthukisa kakhulu ukusebenza kokwakhiwa kanye nengaphezulu le-coating. . Umphumela.
5. Ukuvikelwa kwemvelo nokuphepha
Kokubili i-MC ne-HPMC zishintshiwe zisuka ku-cellulose yemvelo futhi zinokubola okuhle kwe-biodegradability kanye nezakhiwo zokuvikela imvelo. Kokubili akunabuthi futhi akunangozi ekusetshenzisweni futhi kuhambisana nezidingo zokuvikelwa kwemvelo, ngakho-ke kuphephe kakhulu ukuthi kusetshenziswe emkhakheni wokudla, imithi kanye nezimonyo.
Nakuba i-methylcellulose (MC) ne-hydroxypropylmethylcellulose (HPMC) zifana ngesakhiwo samakhemikhali, ngenxa yamaqembu ahlukile ahlukile, ukuncibilika kwawo, ukugeleza okushisayo, umsebenzi ongaphezulu, inqubo yokukhiqiza kanye nokusetshenziswa kuhlukile. Kunomehluko osobala emikhakheni nakwezinye izici. I-MC ifanele izindawo zokushisa eziphansi kanye nezidingo ezilula zokuqina kanye nokugcinwa kwamanzi, kuyilapho i-HPMC ifaneleka kakhulu ezimbonini eziyinkimbinkimbi, ezenza imithi nezokwakha izicelo ngenxa yokuncibilika kwayo okuhle nokuzinza kokushisa.
Isikhathi sokuthumela: Oct-25-2024