Iyini iHydroxypropyl methylcellulose?

1. Isingeniso

IHydroxypropyl methylcellulose (HPMC) iyi-polymer encibilika emanzini esetshenziswa kabanzi etholakala ku-cellulose. Impushana engeyona i-ionic, engenaphunga, engenakunambitheka, emhlophe ukuya kokumhlophe esetshenziswa kakhulu ezimbonini zokudla, ezemithi, nezimonyo. I-HPMC inohlu olubanzi lwezinhlelo zokusebenza, okuhlanganisa ukujiya, ukufaka i-emulsifying, ukumisa okwesikhashana, ukusimamisa, kanye nokwenza ifilimu. Ibuye isetshenziswe njenge-binder, i-lubricant, kanye ne-disintegrant ekukhiqizeni amaphilisi nama-capsules.

2. Izinto ezingavuthiwe

Impahla eluhlaza eyinhloko esetshenziselwa ukukhiqiza i-HPMC i-cellulose, okuyi-polysaccharide eyakhiwe amayunithi e-glucose. I-cellulose ingatholakala emithonjeni ehlukahlukene, kuhlanganise ne-pulp yokhuni, ukotini, neminye imicu yezitshalo. I-cellulose ibe isiphathwa ngenqubo yamakhemikhali ukukhiqiza i-hydroxypropyl methylcellulose.

3. Inqubo Yokukhiqiza

Inqubo yokukhiqiza ye-HPMC ibandakanya izinyathelo ezimbalwa. Okokuqala, i-cellulose iphathwa nge-alkali, njenge-sodium hydroxide, ukuze yakhe i-alkali cellulose. Le cellulose ye-alkali bese isabela nge-methyl chloride kanye ne-propylene oxide ukwenza i-hydroxypropyl methylcellulose. I-hydroxypropyl methylcellulose ibe isihlanzwa futhi yomiswa ukuze yakhe impushana emhlophe.

4. Ukulawulwa Kwekhwalithi

Ukulawulwa kwekhwalithi kuyingxenye ebalulekile yenqubo yokukhiqiza ye-HPMC. Izinga lomkhiqizo linqunywa ukuhlanzeka kwe-cellulose, izinga lokushintshwa kweqembu le-hydroxypropyl, kanye nezinga lokushintshwa kweqembu le-methyl. Ukuhlanzeka kwe-cellulose kunqunywa ngokuhlola i-viscosity yesisombululo, kuyilapho izinga lokushintsha linqunywa ngokuhlola izinga le-hydrolysis ye-hydroxypropyl methylcellulose.

5. Ukupakisha

I-HPMC ivamise ukupakishwa ezikhwameni noma ezigubhu. Izikhwama ngokuvamile zenziwe nge-polyethylene noma i-polypropylene, kuyilapho izigubhu ngokuvamile zenziwe ngensimbi noma ipulasitiki. Izinto zokupakisha kufanele zikhethwe ukuze kuqinisekiswe ukuthi umkhiqizo uvikelekile kumswakama kanye nezinye izici zemvelo.

6. Isitoreji

I-HPMC kufanele igcinwe endaweni epholile, eyomile, kude nelanga eliqondile kanye neminye imithombo yokushisa. Umkhiqizo kufanele futhi uvikeleke kumswakama kanye nezinye izici zemvelo.

7. Isiphetho

I-HPMC iyi-polymer encibilikayo emanzini esetshenziswa kabanzi etholakala ku-cellulose. Isetshenziswa ezimbonini ezahlukahlukene, okuhlanganisa izimboni zokudla, ezemithi, nezimonyo. Inqubo yokukhiqiza ye-HPMC ibandakanya izinyathelo ezimbalwa, okuhlanganisa ukwelashwa kwe-cellulose nge-alkali, ukusabela kwe-alkali cellulose nge-methyl chloride ne-propylene oxide, nokuhlanzwa nokomiswa kwe-hydroxypropyl methylcellulose. Ukulawulwa kwekhwalithi kuyingxenye ebalulekile yenqubo yokukhiqiza, futhi umkhiqizo kufanele ugcinwe endaweni epholile, eyomile, kude nelanga eliqondile kanye neminye imithombo yokushisa.