IHydroxypropyl Methylcellulose (HPMC) iyi-polymer esetshenziswa kakhulu enezinhlelo ezahlukahlukene ezimbonini ezahlukahlukene, kufaka phakathi ezemithi, ukudla, ezokwakha, nezimonyo. Le nhlanganisela ehlukahlukene inezinto eziyingqayizivele ezenza ibe yigugu ekubunjweni nasekusetshenzisweni okuhlukene.
1. Isakhiwo Nezakhiwo
1.1 Isakhiwo se-Molecular: I-HPMC iyi-polymer e-semisynthetic etholakala ku-cellulose, okuyi-biopolymer eningi kakhulu Emhlabeni. Ikhiqizwa ngokuguqulwa kwamakhemikhali e-cellulose, ikakhulukazi ngokuyiphatha nge-propylene oxide ne-methyl chloride ukwethula i-hydroxypropyl kanye namaqembu e-methyl, ngokulandelana.
1.2 Izakhiwo Zomzimba: I-HPMC ngokuvamile itholakala njengempushana emhlophe noma emhlophe. Ayinaphunga, ayinambitheki, futhi ayinabo ubuthi, okwenza iphephe ukusetshenziswa ezindaweni ezahlukene. Ukunyibilika kwe-HPMC kuncike ezintweni ezifana nesisindo samangqamuzana, izinga lokushintshwa, kanye nezinga lokushisa. Ibonisa izinto ezinhle kakhulu zokwenza ifilimu futhi ingakha amafilimu abonisa ngale lapho incibilika emanzini.
1.3 Izakhiwo Zomzimba: Izixazululo ze-HPMC zibonisa ukuziphatha kwe-pseudoplastic, okusho ukuthi i-viscosity yazo yehla ngenani elikhulayo lokugunda. Lesi sakhiwo sinenzuzo ezinhlelweni ezinjengama-coatings, lapho kufiswa khona ukufaka isicelo okulula nokulinganisa.
2. Ukuhlanganisa
Ukuhlanganiswa kwe-HPMC kuhilela izinyathelo ezimbalwa. Okokuqala, i-cellulose ivame ukutholakala ku-pulp yokhuni noma kuma-linter kakotini. Bese, ithola ukusabela kwe-etherification nge-propylene oxide ne-methyl chloride ngaphansi kwezimo ezilawulwayo ukuze yethule i-hydroxypropyl namaqembu e-methyl kumgogodla we-cellulose. I-degree of substitution (DS) yalawa maqembu ingalungiswa ukuze ifanele izakhiwo ze-HPMC polymer ewumphumela wezinhlelo zokusebenza ezithile.
3. Izicelo
3.1 Ezemithi: I-HPMC isetshenziswa kakhulu ekwenziweni kwemithi ngenxa yokuhambisana kwayo kwezinto eziphilayo, izakhiwo ze-mucoadhesive, namandla okukhululwa okulawulwayo. Ivamise ukusetshenziswa njenge-binder, ifilimu yangaphambili, i-disintegrant, kanye ne-ejenti ekhishwa isikhathi eside ekwakhiweni kwethebhulethi. Ukwengeza, ukwakhiwa kwejeli okususelwe ku-HPMC kusetshenziswa amalungiselelo e-ophthalmic ukwandisa isikhathi sokuhlala kwezidakamizwa endaweni ye-ocular.
3.2 Imboni Yokudla: Embonini yokudla, i-HPMC isetshenziswa njenge-thickener, stabilizer, emulsifier, kanye ne-ejenti yokugcina umswakama. Ivame ukutholakala emikhiqizweni yobisi, ezintweni ezibhakwayo, amasoso, naseziphuzweni. I-HPMC isiza ukuthuthukisa ukuthungwa, ukuzinza, nokuzwakala komlomo kwemikhiqizo yokudla ngaphandle kokushintsha ukunambitheka kwayo noma inani lokudla okunempilo.
3.3 Izinto Zokwakha: I-HPMC iyisithako esibalulekile ezintweni zokwakha ezifana nodaka olusekelwe kusimende, ama-renders, namathayela anamathelayo. Isebenza njenge-ejenti yokugcina amanzi, ithuthukisa ukusebenza, inciphisa ukuwohloka, futhi ithuthukise ukunamathela kwalezi zinto kuma-substrates. Udaka olususelwa ku-HPMC lukhombisa ukumelana nokuqhekeka nokushwabana okuthuthukisiwe, okuholela ekwakhiweni okuhlala isikhathi eside futhi okujabulisa ngobuhle.
3.4 Izimonyo: Embonini yezimonyo, i-HPMC isetshenziswa ekwenziweni okuhlukahlukene, okuhlanganisa okhilimu, izinto zokuthambisa, amajeli, namascara. Isebenza njenge-thickener, emulsifier, stabilizer, kanye nefilimu yangaphambili kule mikhiqizo. I-HPMC inika izici ezifiselekayo ze-rheological, ithuthukisa ukuthungwa, futhi inikeza imiphumela ehlala isikhathi eside ekwakhiweni kwezimonyo.
4. Amathemba Ekusasa
Isidingo se-HPMC kulindeleke ukuthi siqhubeke sikhula eminyakeni ezayo, siqhutshwa ukwanda kwezicelo kwezemithi, ukudla, ezokwakha, nezimonyo. Imizamo yocwaningo eqhubekayo igxile ekuthuthukiseni ukwakheka kwamanoveli nokwenza ngcono ukusebenza kwemikhiqizo ekhona. Intuthuko ku-nanotechnology ingase iholele ekuthuthukisweni kwama-nanocomposites asekelwe ku-HPMC anezakhiwo ezithuthukisiwe zemishini, ezishisayo, nezithiyo, okuvula amathuba amasha ezimbonini ezihlukahlukene.
IHydroxypropyl Methylcellulose (HPMC) iyi-polymer eguquguqukayo enezinhlobonhlobo zezinhlelo zokusebenza kuzo zonke izimboni ezahlukahlukene. Inhlanganisela yayo eyingqayizivele yezakhiwo, okuhlanganisa i-biocompatibility, ukulawula i-rheological, kanye nekhono lokwenza ifilimu, kuyenza ibaluleke kakhulu kwezemithi, ukudla, ukwakhiwa, nezimonyo. Ngocwaningo nentuthuko eqhubekayo, i-HPMC ikulungele ukuhlala iyisithako esibalulekile ekwakhiweni nasekusetshenzisweni okuhlukahlukene esikhathini esizayo esibonakalayo.
Isikhathi sokuthumela: Apr-15-2024