Iyini i-HPMC E3?

I-HPMC E3, noma i-hydroxypropyl methylcellulose E3, iwuhlobo lwe-cellulose ether evame ukusetshenziswa embonini yezemithi njenge-binder, thickener, kanye ne-ejenti yokukhululwa eqhubekayo ekwakhiweni kwethebhulethi nama-capsule. Kuyi-polymer engeyona i-ionic etholakala ku-cellulose yemvelo ngokuguqulwa kwamakhemikhali, i-HPMC E3 viscosity range ingu-2.4-3.6 mPas.

Embonini yezemithi, i-HPMC E3 ivame ukusetshenziswa njengenye indlela kwezinye izibophezelo, njengesitashi noma i-gelatin, ngoba iyisitshalo esisekelwe esitshalweni, enye indlela yemifino. Ibuye ihambisane kakhulu nezinhlobonhlobo zezithako zemithi esebenzayo (ama-API) kanye nezinto ezisizayo, okuyenza ibe isithako esiguquguqukayo nesisetshenziswa kakhulu ekwakhiweni kwemithi eminingi.

Enye yezinzuzo ezibalulekile ze-HPMC E3 ezinhlelweni zemithi ikhono layo lokusebenza njengesibophezelo. Uma isetshenziswa njengesibophezelo, i-HPMC E3 isiza ukubamba isithako esisebenzayo nezinye izinto ezisizayo ndawonye, ​​yakhe ithebhulethi noma i-capsule. Lokhu kubalulekile ngoba kuqinisekisa ukuthi ithebhulethi noma i-capsule igcina isimo sayo nobuqotho kuyo yonke inqubo yokukhiqiza nangesikhathi sokugcina nokuhamba.

I-HPMC E3 futhi inezici ezinhle kakhulu zokujiya, eziyenza isebenziseke njenge-ejenti elengayo ekwenziweni koketshezi. Kuyasiza ukuvimbela ukulungiswa kwesithako esisebenzayo nezinye izinhlayiya oketshezini, ukuqinisekisa ukuthi ukumiswa kuhlala ku-homogeneous futhi umfaniswano kuyo yonke impilo yeshalofu yomkhiqizo.

Okunye ukusetshenziswa okubalulekile kwe-HPMC E3 kwezemithi ukusetshenziswa kwayo njenge-ejenti yokukhululwa eqhubekayo. Uma isetshenziswa kulesi sikhundla, i-HPMC E3 isiza ukunciphisa ukukhishwa kwesithako esisebenzayo kusuka kuthebhulethi noma i-capsule, okuvumela ukukhululwa okulawulwayo futhi kancane kancane ngokuhamba kwesikhathi. Lokhu kubaluleke kakhulu emithini edinga ukukhishwa kancane kancane futhi kancane kancane isikhathi eside ukuze igcine umphumela wayo wokwelapha.

I-HPMC E3 iphinde isetshenziswe njenge-ejenti enamathelayo yamaphilisi namaphilisi. Uma isetshenziswa kulo mthamo, isiza ukuvikela isithako esisebenzayo ekonakalisweni ukukhanya, umswakama, nezinye izici zemvelo, iqinisekisa ukuthi umuthi uhlala usebenza futhi uzinzile kukho konke ukuphila kwawo kweshalofu. Izembatho ze-HPMC E3 nazo zingasetshenziswa ukuvala ukunambitheka nephunga lesithako esisebenzayo, kukwenze kunambitheke kakhulu ezigulini.

Ngaphezu kokusetshenziswa kwayo kumaphilisi namaphilisi, i-HPMC E3 iphinde isetshenziswe kwezinye izinhlobo zemithi, ezifana nokhilimu, amajeli, namafutha okugcoba. Kulezi zakhiwo, kusiza ukuthuthukisa i-viscosity kanye nokuthungwa komkhiqizo, okwenza kube lula ukufaka esikhumbeni noma kwenye indawo ethintekile. I-HPMC E3 iphinde isetshenziswe njenge-ejenti ye-gelling ekwakhiweni kwezihloko, isiza ukwakha ukufana okufana nejeli okunikeza ukukhululwa okuqhubekayo kwesithako esisebenzayo.

Umthamo onconyiwe we-HPMC E3 ekwenziweni kwemithi uyahlukahluka kuye ngohlelo oluthile kanye nezici ezifiswayo zomkhiqizo wokugcina. Ngokuvamile, umthamo we-1% kuya ku-5% we-HPMC E3 ngokusekelwe esilinganisweni sesisindo sokwakheka kuyanconywa.