Amalungiselelo okukhishwa okuqhubekayo kanye nokukhishwa okulawulwayo: Ama-ether e-cellulose afana ne-HPMC (hydroxypropyl methylcellulose) avame ukusetshenziswa njengezinto ze-hydrogel skeleton kumalungiselelo okukhishwa okuqhubekayo. Ingakwazi ukulawula izinga lokukhululwa kwezidakamizwa emzimbeni womuntu ukuze kuzuzwe imiphumela yokwelapha. I-HPMC yezinga eliphansi le-viscosity ingasetshenziswa njenge-adhesive, i-thickener kanye ne-ejenti elengayo, kuyilapho i-HPMC yezinga eliphezulu le-viscosity isetshenziselwa ukulungisa amaphilisi ohlaka lwamathambo ezinto ezixubile, amaphilisi akhishwa ngokuqhubekayo, namaphilisi ohlaka lwamathambo ejeli e-hydrophilic.
I-ejenti yokwenza ifilimu yokumboza: I-HPMC inezinto ezinhle zokwenza ifilimu, futhi ifilimu eyakhiwe ifana, isobala, iqinile, futhi akulula ukunamathela. Ingathuthukisa ukuzinza komuthi futhi ivimbele ukushintsha kombala. Ukuhlushwa okuvamile kwe-HPMC kungu-2% kuya ku-10%.
Izinto ezisiza ekwenziweni kwemithi: Ama-cellulose ether adlala indima ebalulekile ekubunjweni kwezinto ezisizayo, njengama-pellets akhishwa njalo, amalungiselelo okukhululwa okuqhubekayo kwamathambo, amalungiselelo okukhululwa okuqhubekayo ahlanganiswe, amaphilisi akhishwa njalo, amafilimu ezidakamizwa ezikhishwa njalo, inhlaka yezidakamizwa. amalungiselelo okukhululwa kanye namalungiselelo okukhishwa okuqhubekayo okuwuketshezi.
I-Microcrystalline Cellulose (MCC): I-MCC iwuhlobo lwe-cellulose olusetshenziswa kakhulu embonini yezemithi, ikakhulukazi ekucindezelweni okuqondile kanye nezinqubo zokomisa ze-granulation ezifana ne-roller compaction ukuze kulungiswe amaphilisi acindezelweyo noma ama-granules.
Ama-Bioadhesives: I-Cellulose ethers, ikakhulukazi i-nonionic kanye ne-anionic ether ephuma njenge-EC (ethylcellulose), i-HEC (i-hydroxyethylcellulose), i-HPC (i-hydroxypropylcellulose), i-MC (i-methylcellulose), i-CMC (i-carboxymethylcellulose) noma i-HPMC (i-hydroxypropylmethylsive widecellulose) esetshenziswa ku-bio. Lawa ma-polymers angasetshenziswa ku-oral, ocular, vaginal and transdermal bioadhesives, eyedwa noma ehlanganiswe namanye ama-polymers.
Ama-Thickeners kanye nama-Stabilizers: Okuphuma ku-cellulose kusetshenziselwa kabanzi ukujiya izixazululo zezidakamizwa kanye nezinhlelo zokusabalalisa ezifana nama-emulsions kanye nokumiswa. Lawa ma-polymers angakhuphula i-viscosity yezixazululo zezidakamizwa ezingenamanzi njengezixazululo zokuhlanganisa ezisekelwe ku-organic. Ukwandisa i-viscosity yezixazululo zezidakamizwa kungathuthukisa i-bioavailability yamalungiselelo e-topical kanye ne-mucosal.
Izihlungi: I-Cellulose kanye nokuphuma kwayo kuvame ukusetshenziswa njengezigcwalisi kumafomu omthamo oqinile njengamaphilisi namaphilisi. Ziyakwazi ukuhambisana nezinye eziningi ezisizayo, ezinert ngokwemithi, futhi azigaywe ngama-enzyme omuntu amathumbu.
Izibophezelo: Ama-cellulose ether asetshenziswa njengezibophezelo phakathi nenqubo yokuhlanganisa ukuze kusizwe ama-granules akheke futhi agcine ubuqotho bawo.
Amaphilisi ezitshalo: Ama-cellulose ethers nawo asetshenziselwa ukwenza ama-capsules ezitshalo, enye indlela evumelana nemvelo kunamaphilisi endabuko asuselwa ezilwaneni.
Amasistimu okulethwa kwezidakamizwa: Ama-cellulose ether angasetshenziswa ukuthuthukisa izinhlobonhlobo zezinhlelo zokulethwa kwezidakamizwa, okuhlanganisa ukukhishwa okulawulwayo kanye namasistimu okukhishwa okubambezelekile, kanye namasistimu okukhishwa kwezidakamizwa okuqondene nesayithi noma okunesikhathi esithile.
Ukusetshenziswa kwama-cellulose ethers embonini yezemithi kuyaqhubeka nokukhula, futhi ngokuthuthukiswa kwamafomu amasha emithamo nezinto ezisizayo ezintsha, isilinganiso sesidingo sawo semakethe kulindeleke ukuthi sikhule ngokuqhubekayo.
Isikhathi sokuthumela: Oct-31-2024