IHydroxypropyl methylcellulose (HPMC) iyi-ether ye-cellulose ebalulekile, esetshenziswa kabanzi ekwakheni, emithini, ekudleni, kumakhemikhali ansuku zonke kanye neminye imikhakha. I-HPMC i-polymer encibilika emanzini etholwe ngokuguqulwa kwamakhemikhali e-cellulose yemvelo, enezici eziningi ezinhle kakhulu zomzimba namakhemikhali.
1. Izinto ezibonakalayo
Ukubukeka kanye nokuma kwazo: I-HPMC ivamise ukuba yimpushana emhlophe noma ephuzi kancane, ayinaphunga, ayinambitheki, futhi inoketshezi oluhle. Ingenza ifilimu efanayo noma ijeli ngokusebenzisa izindlela ezihlukahlukene zokucubungula, okwenza ukuthi yenze kahle ezinhlelweni eziningi zokusebenza.
Ukunyibilika: I-HPMC incibilika kalula emanzini abandayo, kodwa ayincibiliki emanzini ashisayo. Uma izinga lokushisa lifinyelela izinga elithile (imvamisa engu-60-90℃), i-HPMC ilahlekelwa ukuncibilika emanzini bese yenza ijeli. Lesi sakhiwo sisenza sikwazi ukuhlinzeka ngomphumela wokujiya lapho sishisiswa, futhi sibuyele esimweni sesixazululo se-aqueous esobala ngemva kokupholisa. Ngaphezu kwalokho, i-HPMC incibilika kancane kuzincibilikisi zemvelo njenge-ethanol.
I-Viscosity: I-viscosity yesisombululo se-HPMC ingenye yezakhiwo zayo ezibalulekile zomzimba. I-viscosity incike esisindweni sayo samangqamuzana kanye nokugxila kwesixazululo. Ngokuvamile, lapho isisindo samangqamuzana sikhulu, siphakamisa i-viscosity yesisombululo. I-HPMC inezinhlobonhlobo ze-viscosity futhi ingashintshwa ngokuvumelana nezidingo ezithile zohlelo lokusebenza, okwenza isetshenziswe kabanzi embonini yokwakha, ekhemisi, yamakhemikhali yansuku zonke nezinye.
Isakhiwo sokwenza ifilimu: I-HPMC inendawo enhle kakhulu yokwenza ifilimu. Ingenza ifilimu esobala futhi eqinile ngemva kokuncibilika emanzini noma kumakhemikhali ezinto eziphilayo. Ifilimu inokumelana okuhle kwamafutha kanye namafutha, ngakho-ke ivame ukusetshenziswa njengento yokugqoka ezindaweni zokudla kanye nemithi. Ngaphezu kwalokho, ifilimu ye-HPMC nayo inokumelana nokuswakama okuhle futhi ingavikela ngempumelelo izinto zangaphakathi kumswakama.
Ukuzinza kwe-thermal: I-HPMC inokusimama okuhle kokushisa. Nakuba ilahlekelwa ukunyibilika futhi yakha ijeli ekushiseni okuphezulu, inokusimama okuhle kakhulu kokushisa esimweni esomile futhi ingamelana namazinga okushisa aphezulu okucubungula ngaphandle kokubola. Lesi sici siyinikeza inzuzo ekucubunguleni izinga lokushisa eliphezulu.
2. Izakhiwo zamakhemikhali
Ukuzinza kwamakhemikhali: I-HPMC inokusimama okuhle kwamakhemikhali ezingeni lokushisa legumbi futhi izinzile kuma-acids, ama-alkali nosawoti. Ngakho-ke, kumakhemikhali amaningi okusabela noma amasistimu okwakhiwa, i-HPMC ingaba khona njengesiqinisi futhi akulula ukusabela ngamakhemikhali nezinye izithako.
Ukuzinza kwe-pH: I-HPMC ihlala izinzile ebangeni le-pH 2-12, okuyenza isebenziseke ezindaweni ezihlukene ze-pH. I-HPMC ngeke ibhekane ne-hydrolysis noma ukuwohloka ngaphansi kwezimo ezine-asidi noma ezine-alkaline, okuyenza isetshenziswe kabanzi ekudleni, emithini, nasezintweni zokugcoba.
I-Biocompatibility kanye nokungewona ubuthi: I-HPMC inokuhambisana okuhle kwe-biocompatibility futhi ingasetshenziswa ngokuphepha kwezokwelapha, ukudla kanye nezinye izinkambu ezinezidingo eziphezulu kakhulu zempilo yabantu. I-HPMC ayinabo ubuthi futhi ayicunuli, futhi ngeke ihlukaniswe ibe ama-molecule amancane ngama-enzyme okugaya emzimbeni, ngakho-ke ingasetshenziswa njenge-ejenti elawulwayo yokukhululwa kwezidakamizwa noma ukuqina kokudla.
Ukuguqulwa kwamakhemikhali: I-HPMC iqukethe inani elikhulu lamaqembu e-hydroxyl esakhiweni sawo samangqamuzana, angathuthukiswa noma anikezwe izakhiwo ezintsha ngokuqhubeka nokuguqulwa kwamakhemikhali. Isibonelo, ngokusabela nge-aldehydes noma ama-asidi aphilayo, i-HPMC ingalungisa imikhiqizo enokumelana nokushisa okuphezulu noma ukumelana namanzi. Ukwengeza, i-HPMC ingabuye ihlanganiswe namanye ama-polymer noma izithasiselo ukwenza izinto eziyinhlanganisela ukuhlangabezana nezidingo zezinhlelo zokusebenza ezithile.
I-adsorption yomswakama: I-HPMC ine-hygroscopicity eqinile futhi ingakwazi ukumunca umswakama emoyeni. Lesi sakhiwo sivumela i-HPMC ukuthi ijiye futhi ilawule ukuswakama komkhiqizo kwezinye izinhlelo zokusebenza. Kodwa-ke, kwezinye izimo, ukumuncwa komswakama ngokweqile kungase kuthinte ukuzinza komkhiqizo, ngakho-ke umthelela womswakamo we-ambient ekusebenzeni kwe-HPMC udinga ukucatshangelwa lapho usetshenziswa.
3. Izinkambu zokufaka isicelo kanye nezinzuzo
Ngenxa yezakhiwo zayo eziyingqayizivele zomzimba namakhemikhali, i-HPMC inohlu olubanzi lwenani lesicelo emikhakheni eminingi. Isibonelo, emkhakheni wokwakha, i-HPMC isetshenziswa njenge-ejenti yokuqina kanye ne-ejenti yokugcina amanzi ezintweni ezisekelwe usimende ukuthuthukisa ukwakhiwa nokuqina kwezinto zokwakha; emkhakheni wezokwelapha, i-HPMC ivame ukusetshenziswa njenge-adhesive tablet, i-ejenti yokukhululwa elawulwayo, kanye nezinto zokumboza i-capsule; emkhakheni wokudla, isetshenziswa njenge-thickener, emulsifier, kanye ne-stabilizer ukuthuthukisa ukunambitheka nokuthungwa kokudla.
IHydroxypropyl methylcellulose idlala indima engenakushintshwa ezimbonini eziningi ngenxa yezakhiwo zayo ezinhle kakhulu zomzimba namakhemikhali. Ukusebenza kwayo okuvelele ekuncibilikeni kwamanzi, izakhiwo zefilimu, ukuzinza kwamakhemikhali, njll. kwenza i-HPMC ibe into ebalulekile esebenza ngezinto eziningi embonini nempilo yansuku zonke.
Isikhathi sokuthumela: Aug-22-2024