IHydroxypropyl Methylcellulose (HPMC) i-nonionic cellulose ether esetshenziswa kakhulu ezimbonini ezifana nezokwakha, imithi, ukudla, izimonyo kanye nezingubo. Ukuguquguquka kwayo kuvela ezintweni zayo eziyingqayizivele ze-physicochemical ezifana nokujiya, ukubopha, ukwenza ifilimu, ukugcinwa kwamanzi kanye nokuthambisa. Amabanga ahlukene e-HPMC ahlukaniswa ngokuyinhloko ngokwezinga lawo lokushintsha (DS) kanye nokuqukethwe kwe-methoxy ne-hydroxypropyl, ngaphezu kokubonakala kwawo, usayizi wezinhlayiyana nobumsulwa. Lawa mabanga ahlukene e-HPMC anezici ezihlukile zohlelo lokusebenza nokusetshenziswa.
1. Okuqukethwe kwe-Methoxy nokuqukethwe kwe-hydroxypropyl
Okuqukethwe kwe-methoxy ne-hydroxypropyl esikhundleni se-HPMC kuyisici esibalulekile esinquma ukusebenza kwayo. Ngokuvamile, okuqukethwe kwe-methoxy kwe-HPMC kuphakathi kuka-19% no-30%, kanti okuqukethwe kwe-hydroxypropyl kuphakathi kuka-4% no-12%. I-HPMC enokuqukethwe okuphezulu kwe-methoxy ngokuvamile inokuncibilika okungcono kanye nezici zokwenza ifilimu, kuyilapho i-HPMC enokuqukethwe okuphezulu kwe-hydroxypropyl inokunwebeka okungcono nokugcinwa kwamanzi. Le mingcele ithinta ngokuqondile ukusetshenziswa kwe-HPMC. Isibonelo, embonini yezokwakha, okuqukethwe okuphezulu kwe-methoxy kusiza ukuthuthukisa ukugcinwa kwamanzi nokusebenza kokwakhiwa kodaka; emkhakheni wezokwelapha, okuqukethwe okuphezulu kwe-hydroxypropyl kusiza ukuthuthukisa izici zokunamathela nokukhululwa kwezidakamizwa.
2. Ibanga le-viscosity
I-HPMC ingahlukaniswa ibe yi-viscosity ephansi, i-viscosity ephakathi kanye namamaki aphezulu e-viscosity ngokusho kwe-viscosity yesisombululo sayo. I-Viscosity iyinto ebalulekile ebonakalayo ye-HPMC, ngokuvamile ikalwa nge-viscosity ebonakalayo yesixazululo esingu-2% kumasekhondi angu-milliPascal (mPa.s).
I-viscosity ephansi ye-HPMC (efana no-5 mPa.s kuya ku-100 mPa.s): Lolu hlobo lwe-HPMC luvamise ukusetshenziswa ezinhlelweni ezidinga ukujiya okuphansi, njengamaconsi esweni, izifutho nezimonyo. Kulezi zinhlelo zokusebenza, i-viscosity ephansi i-HPMC inganikeza uketshezi oluhle nokusabalalisa okufanayo.
I-HPMC ye-viscosity emaphakathi (isb. 400 mPa.s kuya ku-2000 mPa.s): I-viscosity emaphakathi I-HPMC ivame ukusetshenziswa ezintweni zokwakha, ama-emulsion nama-adhesive ukunikeza imiphumela yokujiya emaphakathi, engalinganisa ukusebenza kokwakha namandla angokomzimba omkhiqizo wokugcina.
I-viscosity ephezulu ye-HPMC (isb. 4000 mPa.s kuya ku-200,000 mPa.s): I-viscosity ephezulu I-HPMC isetshenziswa kakhulu ezinhlelweni ezidinga ukujiya okubalulekile, okufana nodaka, i-putty, izinto zokunamathisela zamathayela kanye nama-coatings. Kule mikhiqizo, i-viscosity ephezulu ye-HPMC isiza ukuthuthukisa ukugcinwa kwayo kwamanzi, i-anti-sagging namandla okubopha.
3. Usayizi wezinhlayiya
Usayizi wezinhlayiyana ze-HPMC futhi uthinta umphumela wayo wohlelo. Ngokuvamile, i-HPMC ingahlukaniswa izinhlayiya ezimahhadla nezinhlayiya ezinhle. I-HPMC yezinhlayiyana eziqinile ivame ukusetshenziswa ezinhlelweni ezidinga ukuhlakazeka ngokushesha noma ukuhlakazwa, kuyilapho i-HPMC yezinhlayiyana ifanele imikhiqizo enezidingo eziphakeme zokubukeka noma edinga ukusatshalaliswa okufanayo okufanayo.
I-HPMC enohlamvu oluqinile: I-HPMC enezinhlayiya ezinkulu inezinga lokuqedwa ngokushesha odakeni oluxutshwe okomile nezinye izinkambu, futhi ingakha ngokushesha isisombululo esifanayo, ngaleyo ndlela ithuthukise ukusebenza kahle kokukhiqiza.
I-Fine-grained HPMC: I-Fine-grained HPMC isetshenziswa kakhulu ezimbonini ezinjengamapende, okokunamathela nezimonyo. Ingenza ungqimba lwefilimu olufana kakhulu phakathi nenqubo yokufaka isicelo, ithuthukise ukucwebezela nokuzwakala komkhiqizo.
4. Ubumsulwa kanye namamaki akhethekile
Ngokwezidingo ezihlukene zohlelo lokusebenza, i-HPMC ingabuye ihlanzwe noma isebenze. I-HPMC enobumsulwa obuphakeme ivamise ukusetshenziswa ezimbonini zemithi nezokudla ukuze kuqinisekiswe ukuphepha kanye nokuhambelana kwezinto eziphilayo komkhiqizo. Ukwengeza, kukhona ama-HPMC athile anemisebenzi ekhethekile, efana ne-HPMC exhunywe ngokuphambana, i-HPMC yokwelashwa okungaphezulu, njll. Lawa mabanga akhethekile e-HPMC anganikeza ukumelana nokuvuvukala okuphakeme, izici eziqinile zokwenza ifilimu noma ukumelana okungcono kwe-asidi ne-alkali.
Ibanga Lemithi I-HPMC: Ibanga Lezemithi I-HPMC inokuhlanzeka okuphezulu futhi ifanele amaphilisi, amaphilisi kanye namalungiselelo okukhululwa okuqhubekayo, okungathuthukisa kakhulu izinga lokukhululwa nokuzinza kwezidakamizwa.
Ibanga lokudla i-HPMC: Ibanga lokudla i-HPMC isetshenziswa njengesigxivizo sokudla, isiqinisi kanye nesishumbisi ukuze kuqinisekiswe ukuphepha nokunambitha kokudla.
I-HPMC yezinga lezimboni: I-HPMC esetshenziswa ekwakheni, okokumboza nezinye izinkambu ingase iqukathe inani elincane lokungcola, kodwa inganikeza umnotho ophezulu kanye nokusebenza okuhle kokucubungula.
5. Izinkambu zokufaka isicelo kanye nokukhetha
Amamaki ahlukene e-HPMC asetshenziswa kabanzi ekwakheni, kwezokwelapha, ekudleni, kwezimonyo nakweminye imikhakha. Lapho ukhetha ibanga elifanele le-HPMC, izici ezifana ne-viscosity, okuqukethwe okuhlukile, usayizi wezinhlayiyana nokuhlanzeka kufanele kucatshangelwe ngokuvumelana nezidingo zezinhlelo zokusebenza ezithile.
Inkambu yokwakha: Ezimpahleni zokwakha, i-HPMC isetshenziswa kakhulu njenge-thickener, igcina amanzi kanye ne-binder. Kuzinhlelo zokusebenza ezifana nodaka olomile nezinamathiselo zamathayela, kubalulekile ukukhetha i-HPMC ene-viscosity efanele nokugcinwa kwamanzi.
Inkambu Yezemithi: Emalungiselweni emithi, i-HPMC isetshenziswa njengempahla yegobolondo le-capsule, i-tablet coating kanye ne-adhesive. Kudingekile ukukhetha amamaki e-HPMC ngokusebenza kokukhishwa kwezidakamizwa okufanele kanye nokuhambisana kwezinto eziphilayo.
Ukudla kanye nezimonyo: Embonini yokudla nezimonyo, i-HPMC isetshenziswa njenge-thickener ne-stabilizer, futhi ubumsulwa nokuphepha kwayo yikona okucatshangelwayo okuyinhloko.
Amabanga ahlukene e-Hydroxypropyl Methylcellulose (HPMC) anezinzuzo zawo kanye nezikophu ezisebenzayo ezinhlelweni zokusebenza. Ukuqonda nokukhetha ibanga elifanele le-HPMC kungathuthukisa ngempumelelo ukusebenza nekhwalithi yomkhiqizo futhi kuhlangabezane nezidingo zemikhiqizo ehlukahlukene yezimboni nezabathengi.
Isikhathi sokuthumela: Aug-21-2024