Ayini amabanga ahlukene e-HPMC?

I-HPMC, noma i-hydroxypropyl methylcellulose, iwuhlobo lokuphuma kokunye okuphuma ku-cellulose okuvame ukusetshenziswa njenge-ejenti ejiyayo, i-emulsifier, kanye ne-stabilizer emikhiqizweni eyahlukene. Kuyimpushana emhlophe, engenaphunga, enganambitheki encibilika emanzini abandayo futhi engancibiliki emanzini ashisayo.

I-HPMC itholakala kumabanga ahlukahlukene, ngalinye linezakhiwo zalo ezihlukile kanye nezinhlelo zokusebenza. Amabanga e-HPMC asuselwe kuzinga lokushintsha (DS) lamaqembu e-hydroxypropyl, okuyisilinganiso senani lamaqembu e-hydroxypropyl ngeyunithi ngayinye ye-anhydroglucose. Uma i-DS iphakeme, amaqembu e-hydroxypropyl engeziwe akhona futhi i-HPMC iba ne-hydrophilic kakhulu.

Amabanga e-HPMC ahlukaniswe abe izigaba ezintathu eziyinhloko: i-DS ephansi, i-DS emaphakathi, ne-DS ephezulu.

I-DS HPMC ephansi ivamise ukusetshenziswa ezinhlelweni lapho kudingeka khona i-viscosity ephansi namandla ejeli aphansi. Leli banga livame ukusetshenziswa ekusetshenzisweni kokudla neziphuzo, njengo-ayisikhilimu, amasoso, nama-gravies. Ibuye isetshenziselwe ekusetshenzisweni kwemithi, njengamaphilisi namaphilisi.

I-Medium DS HPMC isetshenziswa ezinhlelweni lapho kufunwa khona i-viscosity ephakeme namandla ejeli. Leli banga livame ukusetshenziswa ekusetshenzisweni kokudla neziphuzo, okufana nojamu namajeli, kanye nasezintweni zemithi, njengamafutha nama-creams.

I-DS HPMC ephezulu isetshenziswa ezinhlelweni lapho kufunwa khona i-viscosity ephezulu kakhulu namandla ejeli. Leli banga livame ukusetshenziswa ekusetshenzisweni kokudla neziphuzo, njengoshizi neyogathi, kanye nasezintweni zemithi, njengama-suppositories nama-pessaries.

Ngaphezu kwezigaba ezintathu eziyinhloko ze-HPMC, kukhona nezigatshana ezimbalwa. Lezi zigaba ezingaphansi zisekelwe ezingeni lokushintsha, usayizi wezinhlayiyana, kanye nohlobo lweqembu le-hydroxypropyl.

Izinga lokushintshwa kwezigaba ezingaphansi lisuselwe kuzinga lokushintshwa kwamaqembu e-hydroxypropyl. Lezi zigaba ezincane ziyi-DS ephansi (0.5-1.5), i-DS emaphakathi (1.5-2.5), ne-DS ephezulu (2.5-3.5).

Izigatshana zosayizi wezinhlayiyana zisekelwe kusayizi wezinhlayiya. Lezi zigaba ezincane zilungile (ngaphansi kwama-microns ayi-10), okuphakathi (ama-microns ayi-10-20), futhi amaholoholo (ngaphezu kwama-microns angama-20).

Uhlobo lwezigaba zeqembu le-hydroxypropyl lusekelwe ohlotsheni lweqembu le-hydroxypropyl elikhona ku-HPMC. Lezi zigaba ezingaphansi yi-hydroxypropyl methylcellulose (HPMC), hydroxypropyl ethylcellulose (HPEC), kanye ne-hydroxypropyl cellulose (HPC).

I-HPMC iyisithako esisebenza ngezindlela eziningi futhi esisetshenziswa kabanzi emikhiqizweni eyahlukene. Amabanga ahlukene e-HPMC asekelwe ezingeni lokushintsha, usayizi wezinhlayiyana, kanye nohlobo lweqembu le-hydroxypropyl, futhi ibanga ngalinye linezindawo zalo ezihlukile nezindlela zokusebenza.