Yini i-hypromellose phthalate?

I-Hypromellose phthalate (HPMCP) iwuhlobo lwe-excipient yezemithi olusetshenziswa ekwakhiweni kwamafomu omthamo womlomo, ikakhulukazi ekukhiqizeni amaphilisi namaphilisi ane-enteric-coated. Itholakala ku-cellulose, okuyi-polymer yemvelo eyenza ingxenye yesakhiwo sezindonga zamaseli ezitshalo. I-HPMCP iyi-polymer encibilikayo emanzini evame ukusetshenziswa njenge-enteric coating material ngenxa yezakhiwo zayo ezinhle kakhulu zokwenza ifilimu, ukuzinza, kanye nokumelana noketshezi lwesisu.

I-HPMCP yethulwa okokuqala ekuqaleni kwawo-1970 futhi kusukela ngaleso sikhathi isiphenduke into esetshenziswa kabanzi yokuhlanganisa ama-enteric ngenxa yezakhiwo zayo ezihlukile. Ikhiqizwa nge-esterification ye-hypromellose nge-phthalic acid futhi itholakala kuhlu lwamamaki ahlukene, kuye ngezinga le-phthalation nesisindo samangqamuzana e-polymer. Amabanga asetshenziswa kakhulu e-HPMCP yi-HPMCP-55, HPMCP-50, ne-HPMCP-HP-55, anamadigri ahlukene e-phthalation futhi afanele ukusetshenziswa ezinhlotsheni ezihlukene zokwakheka.

Umsebenzi oyinhloko we-HPMCP ekwenziweni kwemithi ukuvikela izithako ezisebenzayo zomuthi ekonakalisweni endaweni ene-asidi yesisu. Uma ithebhulethi noma i-capsule equkethe i-HPMCP idliwe, ukugqoka kuhlala kuqinile esiswini ngenxa ye-pH ephansi, kodwa uma ifomu le-dosage lifinyelela endaweni ene-alkaline yamathumbu amancane, ukugqoka kuqala ukuncibilika nokukhulula izithako ezisebenzayo. Lokhu kukhishwa kubambezelekile kusiza ukuqinisekisa ukuthi umuthi ulethwa endaweni yokusebenza nokuthi ukusebenza kwawo akuphazamisi i-asidi yesisu.