Ibanga lezemithii-hydroxypropyl methylcellulose (HPMC)kuyinto esetshenziswa kakhulu ekwelapheni imithi, esetshenziswa kakhulu embonini yezemithi ngenxa ye-biocompatibility yayo enhle kakhulu nokuzinza.
1. Abasiza ekulungiseleleni imithi
I-HPMC ivame ukusetshenziswa njenge-excipient emalungiselelweni emithi, ikakhulukazi ekulungiseni amaphilisi, amaphilisi, ama-granules, njll. Ingathuthukisa uketshezi kanye nokuqina kwezidakamizwa, futhi ithuthukise ukunyibilika nokutholakala kwezidakamizwa. Njengoba i-HPMC inokunamathela okuhle kakhulu, ukusetshenziswa kwayo kumaphilisi kungathuthukisa ngempumelelo amandla nokuzinza kwamaphilisi.
2. I-ejenti yokukhululwa elawulwayo
I-HPMC isetshenziswa kabanzi kumalungiselelo okukhululwa okulawulwayo. Izinga lokukhishwa kwezidakamizwa lingalungiswa ngokushintsha isisindo samangqamuzana kanye ne-viscosity ye-HPMC. Izakhiwo ezincibilikayo emanzini ze-HPMC ziyenza ikwazi ukwenza amajeli emanzini, ngaleyo ndlela ilawule izinga lokukhishwa kwezidakamizwa futhi izuze ukukhululwa kwezidakamizwa okuqhubekayo. Le mpahla ibaluleke kakhulu ekwelapheni izidakamizwa zezifo ezingapheli ezifana nesifo sikashukela kanye nomfutho wegazi ophezulu.
3. Ama-thickeners wezixazululo nokumiswa
I-HPMC, njenge-thickener, ingakhuphula ngempumelelo i-viscosity yezixazululo nokumiswa futhi ithuthukise ukuzinza nokusebenza kwezidakamizwa. Emalungiselelweni oketshezi, ukusetshenziswa kwe-HPMC kungathuthukisa ukumiswa kwezidakamizwa, kugweme imvula, futhi kuqinisekise ukufana kwezidakamizwa.
4. Amalungiselelo angaphandle
I-HPMC iphinde isetshenziswe kabanzi emalungiselelweni angaphandle (njengama-creams, ama-gel, ama-patches, njll.). Ngenxa yokunamathela kwayo okuhle kanye nezindawo zokuthambisa, i-HPMC ingathuthukisa ukusabalala kanye nokuvunyeleka kwesikhumba kwamalungiselelo angaphandle futhi ithuthukise ukusebenza kahle kwendawo kwezidakamizwa. Ngaphezu kwalokho, i-HPMC inganikeza ukunamathela okuhle lapho ilungiselela ama-patches e-biological ukuqinisekisa ukunamathela okuzinzile kwama-patches esikhumbeni.
5. Amalungiselelo e-Ophthalmic
Emalungiselelweni e-ophthalmic, i-HPMC isetshenziswa njengengxenye yezinyembezi zokwenziwa namaconsi iso. I-viscosity yayo ephezulu kanye nezindawo zokuthambisa zingakhulula ngokuphumelelayo amehlo omile, zinikeze ukuthambisa okuhlala njalo, futhi zithuthukise ukunethezeka kwesiguli.
6. Abathwali bezidakamizwa zeNano
Eminyakeni yamuva nje, i-HPMC iphinde yacwaningwa njengenkampani ethwala izidakamizwa ze-nano. Ngokuhlanganisa nama-nanoparticles, i-HPMC ingathuthukisa i-bioavailability yezidakamizwa, inciphise ubuthi, futhi ifinyelele ukulethwa kwezidakamizwa okuhlosiwe. Lolu cwaningo luhlinzeka ngemibono emisha yokwelashwa kwezifo ezingalapheki njengomdlavuza.
7. Izinto Ezisetshenziswa Ngegazi
I-biocompatibility ye-I-HPMCfuthi ikwenza kube usizo emkhakheni wezinto eziphilayo. Ingasetshenziselwa ukulungisa ama-biofilms, ama-scaffolds, njll., ukukhuthaza ukukhula kwamaseli nokuvuselelwa kabusha, futhi isetshenziselwa ubunjiniyela bezicubu kanye nemithi yokuvuselela.
8. Ezinye izinhlelo zokusebenza
Ngaphezu kwalokhu kusetshenziswa okungenhla, i-HPMC iphinde isetshenziswe ekudleni, kwezimonyo nakweminye imikhakha njengendlela yokuqinisa nokuqiniswa. Isibonelo, ekudleni, i-HPMC ingasetshenziswa ukuthuthukisa ukuthungwa nokunambitha kokudla; kuzimonyo, ingasetshenziswa njenge-thickener kanye ne-emulsifier ukuthuthukisa ukuzinza nokuzwakala komkhiqizo.
I-HPMC yebanga lezemithi isiphenduke into ebaluleke kakhulu emkhakheni wezokwelapha kanye ne-biomedical ngenxa yokuguquguquka kwayo kanye nokuhambisana okuhle kakhulu kwe-biocompatibility. Ngokuthuthuka kwesayensi nobuchwepheshe, ububanzi bokufaka isicelo kanye nobuchwepheshe be-HPMC buzoqhubeka nokukhula, buhlinzeke ngosizo lokuthuthukiswa kwamalungiselelo emishanguzo nezindlela zokwelapha. Ngokuzayo, ucwaningo nge-HPMC luzojula kakhulu, lubeke isisekelo sokusetshenziswa kwalo emikhakheni eminingi eminingi.
Isikhathi sokuthumela: Nov-07-2024