Umehluko phakathi kwe-HPMC ne-MC

I-Hydroxypropyl methylcellulose (HPMC)na-I-methylcellulose (MC)Zombili zomabili ama-cellulose derivatives asetshenziswa kakhulu kwizimboni ezahlukahlukene, kufaka phakathi ama-Pharmaceuticals, ukudla, izimonyo kanye nokwakha. Naphezu kokufana kwabo, lezi zinto ezimbili zokwakha zinezakhiwo ezihlukile zamakhemikhali kanye nezinhlelo zokusebenza.

1. Isakhiwo samakhemikhali

Kokubili i-HPMC ne-MC kuyizinto ezifuywayo ze-cellulose, kepha umehluko osemqoka ulele emaqenjini amakhemikhali anamathele emuva kwi-cellulose backbone.

I-methylcellulose (MC): Lokhu kwakhiwa yi-methylation ye-cellulose. Kule nqubo, amaqembu we-methyl (-CH3) anamathele emaqenjini ama-hydroxyl ama-molecule we-cellulose. I-methylation degree ngokujwayelekile iyahluka phakathi kwama-20-30%, ngokuya ngebanga le-MC, elithonya i-solubility yalo nezinye izakhiwo.

I-Hydroxypropyl methylcellulose (HPMC): I-KimaCell®HPMC iyinto etholwa yinkimbinkimbi ngokwengeziwe. Ngaphezu kwe-methylation, futhi iqhutshwa i-hydroxypropylation. Amaqembu e-Hydroxypropyl (-ch2chohch3) angeniswa ku-molecule ye-cellulose, kanye namaqembu we-methyl. I-Hydroxypropylation degree kanye ne-methylation degree ye-HPMC ingahluka kakhulu, okunikeza amabanga ahlukahlukene we-HPMC ngezici ezihlukile.

2. Ubuhlakaniselo

I-Solubity ingenye yezinto ezibaluleke kakhulu lapho ziqhathanisa i-MC ne-HPMC. I-solubity yazo zombili lezi zinto zokuphumula ze-cellulose incike ngezinga lokufakwa esikhundleni kanye nokwakhiwa okuthile kwezinto ezibonakalayo.

I-methylcellulose (MC): I-MC iyanyibilika emanzini ashisayo kepha yakha ijeli lapho kupholisa. Le mpahla eyingqayizivele yokwakha ama-gels lapho ifudumala futhi ibuyela esimweni se-liquid lapho kupholisa kungenye yezimpawu ezibaluleke kakhulu ze-MC. Kuyakhubazeka emanzini abandayo, kepha kuyancibilika emanzini ashisayo ngaphezu komkhawulo othile wokushisa (50-70 ° C), nenqubo ye-gelation ibuye kabusha.

I-Hydroxypropyl methylcellulose (HPMC): I-HPMC, ngakolunye uhlangothi, iyancibilika emanzini abandayo nawashisayo. Lokhu kwenza ukuthi kuguquguquke ngokwengeziwe uma kuqhathaniswa ne-MC. I-solubity ye-HPMC ithonywa uhlobo lokufakwa esikhundleni (isilinganiso se-methyl kumaqembu we-hydroxypropyl) kanye nebanga le-viscosity. Degrees asptiation aphezulu athambekele ekwenzeni i-HPMC incibilike kakhulu emanzini emazingeni okushisa aphansi.

3. Ukuhlakanipha

I-VisCosity idlala indima ebalulekile kuzicelo eziningi, ikakhulukazi ezimbonini zezemithi nezokudla.

I-methylcellulose (MC): I-viscosity ye-KimaCell®mc Solutions ixhomekeke ekushiseni lokushisa. I-viscosity inyuka lapho ifudumala, futhi ikhombisa into ye-gelation. Izinga lokufaka esikhundleni futhi lithinta i-viscosity, elinamazinga aphezulu aphezulu ngokuvamile aphumela ekubonakaleni okuphezulu.

I-Hydroxypropyl methylcellulose (HPMC): I-HPMC ngokuvamile inephrofayela yokubona eguquguqukayo ngokuqhathaniswa ne-MC. I-Viscosity ye-HPMC nayo ithonywa ngezinga lokufaka esikhundleni, kepha lihlala lizinzile kulo lonke uhla lwamazinga okushisa. Ngokwengeziwe, i-HPMC ingalinganiswa ukuba ibe ne-visosities ehlukahlukene, kusuka kokuphansi kuya phezulu, kuya ngohlelo lokusebenza okuhlosiwe.

4. Izinja

Kokubili i-MC ne-HPMC kusetshenziswa kakhulu kwizimboni zezemithi, zokudla, zokudla kanye nezimonyo, kepha izakhiwo ezithile zalowo nalowo zibenza zilungele izinhlelo ezithile.

I-methylcellulose (MC):

Amakhemikhali: I-MC ivame ukusetshenziswa njenge-binder, ukuqhelelana ne-ejenti yethebhulethi ngenxa yezakhiwo zayo ze-gelation. Iphinde isetshenziswe ezakhiweni ezilawulwa ngokulawulwa.

Imboni yokudla: I-MC isetshenziswa njengomuntu omkhulu wokudla, i-emulsifier, ne-stabilizer. Impahla yayo eyakha i-gel ibalulekile ekwenzeni imikhiqizo efana no-ayisikhilimu, ukugqoka kwesaladi, nemikhiqizo yokubhaka.

Izimonyo: I-MC isetshenziswa kwezimonyo ze-cosmetics ngokuqina kwayo, i-eculsung, kanye nokuzinza izakhiwo emikhiqizweni efana ne-lotion, ama-shampoos, kanye nokhilimu.

I-Hydroxypropyl methylcellulose (HPMC):

Amakhemikhali: I-HPMC isetshenziswa kabanzi njenge-ejenti ye-binder ne-ament elawulwa ngokwakhiwa kwethebhulethi. Iphinde isetshenziswe kwizixazululo ze-Ophthalmic njenge-lubricant nasezinhlelweni ezenzelwe izidakamizwa ezisuselwa ku-gel.

Imboni yokudla: I-HPMC isetshenziswa ekubhaka kwamahhala-gluten-free, njengoba ilingisa ukuthungwa kanye nokuqina kwe-gluten enhlama. Iphinde isetshenziswe njenge-stabilizer ne-emulsifier ekudleni okuhlukahlukene okucutshunguliwe.

Ukwakha: I-HPMC isetshenziswa njengesengezo kuso usimende, udaka, kanye nezinamathekisayo. Kuthuthukisa ukusebenziseka, ukugcinwa kwamanzi, kanye nokunamathela.

5. Ezinye izakhiwo

Hyrroscopicity: I-HPMC ngokuvamile i-hygroscopic ngokwengeziwe (ukuheha amanzi) kune-MC, okwenza kube lusizo kuzicelo lapho kugcinwa khona umswakama.

Ukuqina okushisayo: I-MC ivame ukukhombisa ukuqina okungcono okushisayo ngenxa yendawo yaso ye-gelation. I-HPMC, ngenkathi iqinile ebangeni lokushisa elibanzi, kungenzeka linganikezi umphumela ofanayo we-gelation we-gelal njenge-MC.

6. Isifinyezo of umehluko

Ngenkathi bobabiliI-HPMCna-MCziyi-cellulose derivativeves enezicelo ezigqamile, izinhlaka zazo ezihlukile zamakhemikhali kanye nezakhiwo zizenza zilungele ukusetshenziswa okuhlukile. I-MC ibaluleke kakhulu kuzinhlelo zokusebenza ezizuzwa yimpahla yayo ye-gelation, kanti ukuzinza kwe-HPMC ephakeme kanye nokuqina okushisayo kwenza kube hlinzeka ngezindlela eziningi eziguquguqukayo kuzo zonke izimboni, kufaka phakathi ukucubungula ukudla kanye nemithi. Ukuqonda lo mehluko kusiza ekukhetheni impahla efanelekile yezinhlelo ezithile.