Synthesis kanye nezimpawu zomkhiqizo ze-hydroxypropyllylylylylylylyllose

I-Hydroxypropyl methylcellulose (HPMC)yi-ether ye-cellulose engeyona eye-ionic eyenziwe kusuka ku-cellulose yemvelo ngokuguqulwa kwamakhemikhali. Kusetshenziswa kabanzi emikhakheni yokwakha, umuthi, ukudla nezimonyo. Inqubo yayo ye-synthesis kanye nezimpawu zomkhiqizo zinikeza ukusebenza okuhlukile futhi kungahlangabezana nezidingo ezahlukahlukene zezimboni.

1. Synthesis we-hydroxypropylllylylykylm methylcellulose

Ukulungiswa kweKimacell®HPMC kusebenzisa i-cellulose yemvelo njengokuqukethwe okungavuthiwe futhi ngamakhemikhali ukukuguqula ngokwelashwa kwe-alkali nokuphendula okuthe xaxa. Inqubo ethile ye-synthesis ekhethekile ifaka lezi zinyathelo ezilandelayo:

I-Alkalization of Cellulose

Izinto zokwakha ze-cellulose (njenge-pulp yekotoni noma ipulpiti yekotini) zixutshwe nesixazululo se-sodium hydroxide kanye ne-alkalised emazingeni okushisa athile nengcindezi yokukhiqiza i-Alkali Cellulose. Inqubo ye-alkalization yandisa i-cellulose molecular chain futhi yandisa ukuvumelanisa ne-ejenti etherishini.

Ukusabela okuthe xaxa

I-Alkali Cellulose iphendulwa nge-formaldehyde ne-propelene glycol propylene oxide ukukhiqiza i-hydroxypropyllylylylylylyl. Ngesikhathi sokuphendula, ukusabela kwe-methylution kanye ne-hydroxyproppyration kwenzeka ngasikhathi sinye, ukufaka ingxenye yamaqembu ama-hydroxyl kumaketanga ama-molecular molecular, wakha i-HPMC ngezinga elithile lokufakwa esikhundleni (DS) kanye ne-molar anclusiotution (NS).

Ukungathathi hlangothi nokugeza

Ngemuva kokuthi ukusabela sekuqediwe, kufakwa isixazululo se-acid ku-autrise ukuze kufakwe ingxube yokusabela, bese kugezwa ngamanzi ukususa izinto zokwakha ezingafakwanga kanye nemikhiqizo yokuthola i-HPMC ehlanzekile.

Ukomisa nokuchoboza

I-WET HPMC yomiswe endaweni ephansi yomswakama futhi ichotshozwe ibe yimpuphu ukuthola umkhiqizo wokugcina. Ubukhulu bezinhlayiyana bomkhiqizo bungashintshwa ngokuya ngezidingo zohlelo lokusebenza.

2. Izici zomkhiqizo ze-hydroxypropyllylyll methylcellulose

I-HPMC inezindawo ezihlukile ngokomzimba nangamakhemikhali, ezenza kube kuhle kakhulu kuzinhlelo zokusebenza ezahlukahlukene:

I-solubity yamanzi amahle kakhulu

I-HPMC ingancibilika ngokushesha emanzini abandayo ukwakha ikhambi le-colloidal elibonakalayo, futhi ukulekelela kwalo akuthintwa ubunzima bamanzi. I-HPMC iyi-infoluble emanzini ashisayo, kepha ingabuyisela i-soulity ngemuva kokuba amanzi esepholile. Le mpahla yenza ukuthi ilungele izigcawu ezidinga ukusebenza kwe-gelation okushisayo.

Izakhiwo Eziqinile Zamakhemikhali

I-HPMC yinto engeyona eye-ionic ngokubekezelela okuhle kuma-acid, ama-alkali kanye nosawoti, futhi angahlala azinzile ngaphansi kwezimo ezahlukahlukene ze-PH.

Izakhiwo ezinhle zokuqina kanye nokunamathelisa

Isixazululo samanzi se-HPMC sinomphumela omkhulu wokuqina, futhi ukubonakala kwaso kukhuphuka ngokunyuka kwesisindo nokuhlushwa kwamangqamuzana. Ukunamathela kwayo kanye nezakhiwo ezenziwe ngefilimu zikwenza kwenze kahle ezitsheni nasezinamathiselwe.

Izakhiwo ezinhle kakhulu ze-gelation ze-thermal

Isixazululo se-HPMC sithola ukuguquguquka okuguqukayo lapho kufudunyezwa futhi kubuyela esimweni se-liquid ngemuva kokupholisa. Le mpahla ye-gelelation eshisayo isetshenziswa kabanzi ezintweni zokwakha (njengosimende ngodaka) ukwenza ngcono ukusebenza kokwakha.

Non-anobuthi futhi ihambisane

Njengoba i-HPMC isuselwa ku-cellulose yemvelo futhi ine-biocompse enhle kanye nokuphepha, isetshenziswa kabanzi ezithandweni zokudla kanye nama-matripietics amabala, njengokuqukethwe kwamathebhulethi alawulwa izidakamizwa.

Ukuvumelana nezimo ukulungisa ukusebenza

Izinga lokufakwa esikhundleni (DS kanye ne-MS) ye-Kimacell®HPMC zingashintshwa ngokuya ngesidingo, ngaleyo ndlela siguqule i-solubity yayo, ukubonwa kokushisa kwayo nezinye izakhiwo ukuze kuhlangatshezwane nezidingo zobuchwepheshe zezicelo ezahlukahlukene.

3. Izinkambu zohlelo lokusebenza namathemba

I-HPMC Ingasetshenziswa njengomuntu okhudlwana noMdaka wokunciphisa amanzi ensimini yokwakha, njenge-ejenti yokwakheka kwezidakamizwa ensimini yezemithi, futhi njenge-emulsifier ne-stabilizer embonini yokudla. Ngokuthuthuka kwe-Chemistry Chemistry ne-Stustable Development, ukuhlanganiswa kwamandla aphansi kanye nokuthuthukiswa kokusebenza okuphezulu kwe-HPMC kuzoba ukugxila kocwaningo lwesikhathi esizayo.

I-Hydroxypropylylylylyly vele yaba yinto ebaluleke kakhulu futhi ebaluleke kakhulu embonini yanamuhla kanye nokuphila kwansuku zonke ngokusebenza kwayo okuphezulu nokuguquguquka okuhlukahlukene.