IHydroxypropyl methyl cellulose I-HPMC iwuhlobo lwe-ether engeyona ionic cellulose exubile, ehlukile kune-ionic methyl carboxymethyl cellulose ether exubile, futhi ayisebenzi ngezinsimbi ezisindayo. Ngenxa yezilinganiso ezihlukene zokuqukethwe kwe-methoxyl nokuqukethwe kwe-hydroxypropyl ku-hydroxypropyl methylcellulose nama-viscosities ahlukene, isiphenduke izinhlobo ezihlukahlukene ezinezakhiwo ezihlukene, isibonelo, okuqukethwe okuphezulu kwe-methoxyl nokuqukethwe kwe-hydroxypropyl ephansi Ukusebenza kwayo kuseduze nalokho kwe-methyl cellulose, futhi izinhlobo ezinokuqukethwe okuphansi kwe-methoxyl kanye nokuqukethwe okuphezulu kwe-hydroxypropyl, ukusebenza kwayo kusondele kulokho kwe-hydroxypropyl methylcellulose. Kodwa-ke, ezinhlobonhlobo ezihlukahlukene, nakuba inani elincane kuphela leqembu le-hydroxypropyl noma inani elincane leqembu le-methoxy liqukethwe, ukuncibilika kuma-solvents ephilayo noma izinga lokushisa le-flocculation kusixazululo samanzi lihluke kakhulu.
1. Ukuncibilika kwe-hydroxypropyl methylcellulose
①Ukunyibilika kwe-hydroxypropyl methyl cellulose emanzini I-Hydroxypropyl methyl cellulose empeleni iyi-methyl cellulose elungiswe yi-propylene oxide (methyl oxypropylene), ngakho-ke isenezinto ezifanayo njenge-methyl cellulose. I-Cellulose ifana nokuncibilika kwamanzi abandayo kanye nokungancibiliki kwamanzi ashisayo. Nokho, ngenxa yeqembu le-hydroxypropyl eliguquliwe, izinga lokushisa layo le-gelation emanzini ashisayo liphakeme kakhulu kunalelo le-methyl cellulose. Isibonelo, i-viscosity yesisombululo esinamanzi se-hydroxypropyl methylcellulose enokuqukethwe kwe-methoxyl okungu-2% DS=0.73 kanye nokuqukethwe kwe-hydroxypropyl MS=0.46 kungu-500 mpa?s ku-20°C. Izinga lokushisa lejeli layo Ingafinyelela ku-100°C, kuyilapho i-methylcellulose ezingeni lokushisa elifanayo icishe ibe ngu-55°C. Ngokuqondene nokuncibilika kwayo emanzini, nayo ithuthukiswe kakhulu. Isibonelo, i-pulverized hydroxypropyl methylcellulose (i-granular shape engu-0.2~0.5mm ku-20°C ene-viscosity engu-4% ye-aqueous solution efika ku-2pa?s ingasetshenziswa Emazingeni okushisa asekamelweni, incibilika kalula emanzini ngaphandle kokupholisa.
②Ukunyibilika kwe-hydroxypropyl methyl cellulose kuzinyibilikisi zemvelo Ukuncibilika kwe-hydroxypropyl methyl cellulose kuzinyibilikisi zemvelo nakho kungcono kunaleyo kwe-methyl cellulose, futhi i-methyl cellulose idinga ukuba ne-degree of methoxyl esikhundleni seMikhiqizo engaphezu kuka-2.1, kanye ne-high-viscosity equkethe i-methylcellulose i-hydroxypropyl MS=1.5~1.8 kanye ne-methoxy DS=0.2~1.0, futhi isamba sedigri yokushintsha ngaphezu kuka-1.8 ancibilika ku-anhydrous solutions methanol kanye ne-ethanol solutions medium, thermoplastic and water-soluble. Iphinde inyibilike kuma-hydrocarbon ane-chlorine afana ne-dichloromethane ne-chloroform, nasezincibilikisini eziphilayo njenge-acetone, isopropanol ne-diacetone alcohol. Ukuncibilika kwayo ezincibilikisini eziphilayo kungcono kunokuncibilika emanzini.
2. Izinto ezithinta i-viscosity ye-hydroxypropyl methylcellulose
Izinto ezinomthelela we-hydroxypropyl methyl cellulose viscosity Ukunqunywa kwe-viscosity okujwayelekile kwe-hydroxypropyl methyl cellulose, njengamanye ama-cellulose ether, kusekelwe kusixazululo samanzi esingu-2% ku-20°C. I-viscosity yomkhiqizo ofanayo iyanda ngokukhula kokuhlushwa. Emikhiqizweni enezisindo zamangqamuzana ahlukene ekugxiliseni okufanayo, imikhiqizo enesisindo samangqamuzana amakhulu ine-viscosity ephezulu. Ubudlelwano bayo nezinga lokushisa bufana nobe-methyl cellulose. Lapho izinga lokushisa likhuphuka, i-viscosity iqala ukwehla, kodwa lapho ifinyelela izinga lokushisa elithile, i-viscosity iyanda ngokuzumayo futhi i-gelation ivela. Izinga lokushisa lejeli lemikhiqizo ye-viscosity ephansi liphezulu. iphezulu. Iphuzu layo lejeli alihlobene kuphela ne-viscosity ye-ether, kodwa futhi nesilinganiso sokwakheka kwe-methoxy ne-hydroxypropyl ku-ether kanye nenani eliphelele lokushintsha. Kumele kuqashelwe ukuthi i-hydroxypropyl methylcellulose nayo iyi-pseudoplastic futhi isisombululo sayo sizinzile ezingeni lokushisa elivamile ngaphandle kokuwohloka kwe-viscosity ngaphandle kokuthi kungenzeka ukuwohloka kwe-enzymatic.
3. I-Hydroxypropyl methylcellulose acid kanye nokumelana ne-alkali
I-Hydroxypropyl methylcellulose acid kanye nokumelana ne-alkali I-Hydroxypropyl methylcellulose ngokuvamile izinzile ku-asidi ne-alkali, futhi ayithinteki ebangeni le-pH 2~12. Ingakwazi ukumelana nenani elithile le-asidi ekhanyayo. Njenge-formic acid, i-acetic acid, i-citric acid, i-succinic acid, i-phosphoric acid, i-boric acid, njll. Nokho, i-asidi egxilile inomphumela wokunciphisa i-viscosity. I-alkali efana ne-caustic soda, i-caustic potash kanye namanzi e-lime ayinamthelela kuwo, kodwa ingakhuphula kancane i-viscosity yesisombululo, bese kuba khona into yokwehla kancane esikhathini esizayo.
4. Ukuxutshwa kwe-hydroxypropyl methylcellulose
Ingxubevange ye-Hydroxypropyl Methyl Cellulose Isixazululo se-Hydroxypropyl methyl cellulose singaxutshwa nenhlanganisela ye-polymer encibilika emanzini ukuze ibe isixazululo esifana nesesisobala esine-viscosity ephezulu. Lezi zinhlanganisela ze-polymer zihlanganisa i-polyethylene glycol, i-polyvinyl acetate, i-polysiloxane, i-polymethyl vinyl siloxane, i-hydroxyethyl cellulose ne-methyl cellulose. Izinhlanganisela ze-polymer zemvelo ezifana ne-gum arabic, i-cust bean gum, i-karaya gum, njll. nazo zinokuhlangana okuhle nesixazululo sayo. IHydroxypropyl methylcellulose ingabuye ixutshwe ne-mannitol noma i-sorbitol esters ye-stearic acid noma i-palmitic acid, futhi ingaxutshwa ne-glycerin, i-sorbitol ne-mannitol. Lezi zinhlanganisela zingasetshenziswa njenge-hydroxypropyl methylcellulose. I-plasticizer esekwe ku-cellulose.
5. Ukungancibiliki nokuncibilika kwamanzi kwe-hydroxypropyl methylcellulose
I-insolubilized water-soluble cellulose ethers ye-hydroxypropyl methylcellulose ingaxhunyaniswa phezulu ne-aldehyde, futhi lawa ma-ether ancibilikayo emanzini ancibilika esixazululo futhi angancibiliki emanzini. I-aldehyde eyenza i-hydroxypropyl methylcellulose ingancibiliki ihlanganisa i-formaldehyde, i-glyoxal, i-succinaldehyde, i-adipaldehyde, njll. Uma usebenzisa i-formaldehyde, ukunakwa okukhethekile kufanele kukhokhwe inani le-pH yesisombululo, phakathi kwayo i-glyoxal isabela ngokushesha. Ngakho-ke, i-glyoxal ivame ukusetshenziswa njenge-ejenti exhumanisayo ekukhiqizeni izimboni. Umthamo walolu hlobo lwe-ejenti exhumanisayo esixazululweni ngu-0.2% ~ 10% wesisindo se-ether, okungcono kakhulu u-7% ~ 10%, futhi u-3.3% ~ 6% nguyena ofaneleka kakhulu we-glyoxal. Izinga lokushisa elijwayelekile lokwelapha ngu-0~30℃, futhi isikhathi singu-1~120min. Ukusabela kokuxhumanisa kufanele kwenziwe ngaphansi kwezimo ze-acidic. Ngokuvamile, i-asidi eqinile ye-inorganic noma i-organic carboxylic acid yengezwa esixazululo ukulungisa i-pH yesisombululo ibe ngu-2 ~ 6, okungcono kakhulu phakathi kuka-4 ~ 6, bese kwengezwa ama-aldehydes ukwenza ukusabela okuxhumanisa. . Ama-acids asetshenzisiwe afaka i-hydrochloric acid, i-sulfuric acid, i-phosphoric acid, i-formic acid, i-acetic acid, i-hydroxyacetic acid, i-succinic acid noma i-citric acid, phakathi kwayo i-formic acid noma i-acetic acid ifaneleka, futhi i-formic acid iyona engcono kakhulu. I-asidi ne-aldehyde nazo zingangezwa kanyekanye ukuze kuvunyelwe isixazululo ukuthi sinqamule ebangeni le-pH elifunekayo. Lokhu kusabela kuvame ukusetshenziswa enqubweni yokugcina yokwelapha ekulungiseni i-cellulose ethers. Ngemuva kokuthi i-cellulose ether ingancibilikisiwe, kulula ukuyigeza futhi ihlanzwe ngamanzi ku-20 ~ 25°C. Lapho umkhiqizo usetshenziswa, into ene-alkaline ingafakwa esixazululweni somkhiqizo ukuze kulungiswe i-pH yesisombululo ukuze ibe yi-alkaline, futhi umkhiqizo uzoncibilika esixazululweni ngokushesha. Le ndlela iphinde isebenze kusixazululo se-cellulose ether esenziwe ifilimu bese ifilimu icutshungulwa ukuze iyenze ifilimu engancibiliki.
6. I-Hydroxypropyl methylcellulose imelana nama-enzyme
IHydroxypropyl methylcellulose imelana nama-enzyme. Ngokombono, i-cellulose derivatives, njengeqembu ngalinye le-anhydroglucose, ineqembu elibambe iqhaza eliqinile, okungelula ukuthi lingenwe ama-microorganisms, kodwa empeleni umkhiqizo oqediwe Uma inani lokufaka esikhundleni lidlula i-1, lizophinde lehliswe ngama-enzyme, okusho ukuthi izinga lokushintshwa kweqembu ngalinye ochungechungeni lwe-cellulose alifani ngokwanele, futhi ama-microorganisms angaguguleka eduze kwamaqembu e-anhydroglucose angashintshiwe ukuze akhe ushukela. , ezimuncwa njengezakhi zamagciwane. Ngakho-ke, uma izinga le-etherification esikhundleni se-cellulose likhuphuka, ukumelana nokuguguleka kwe-enzymatic kwe-cellulose ether nakho kuyathuthukiswa. Kubikwa ukuthi i-viscosity eyinsalela ye-hydroxypropyl methylcellulose (DS=1.9) ingu-13.2%, i-methylcellulose (DS=1.83) ingu-7.3%, kanti i-methylcellulose (DS=1.66) ingu-3.8%, kanti i-hydroxyethyl cellulose ingu-1.7%. Kuyabonakala ukuthi ikhono le-anti-enzyme le-hydroxypropyl methylcellulose linamandla. Ngakho-ke, ukumelana okuhle kakhulu kwe-enzyme ye-hydroxypropyl methylcellulose, kuhlanganiswe ne-dispersibility yayo enhle, ukuqina kanye nezakhiwo zefilimu, ngokuvamile kusetshenziselwa ukumboza amanzi-emulsion, njll, futhi ngokuvamile akudingi ukungezwa kwezilondolozi. Kodwa-ke, ukuze kugcinwe isikhathi eside isisombululo noma ukungcoliswa okungenzeka kwezwe langaphandle, ama-preservatives angangezwa njengendlela yokuzivikela, futhi ukukhetha kunganqunywa ngokuvumelana nezidingo zokugcina zesisombululo. I-Phenylmercuric acetate ne-manganese fluorosilicate yizilondolozi ezisebenzayo, kodwa zinakho kokubili Ubuthi, kufanele kuqashelwe ukusebenza, futhi umthamo ngokuvamile u-1 ~ 5mg we-phenylmercuric acetate ilitha ngalinye lesixazululo.
7. Izakhiwo zefilimu ye-hydroxypropyl methylcellulose
Ukusebenza kwefilimu ye-hydroxypropyl methylcellulose I-Hydroxypropyl methylcellulose inezinto ezinhle kakhulu zokwakha ifilimu, futhi isixazululo sayo esinamanzi noma isixazululi se-organic simbozwa epuleti lengilazi, futhi lingabi nambala futhi libe sobala ngemva kokumiswa. Futhi ifilimu enzima. Inokumelana okuhle nomswakama futhi ihlala iqinile emazingeni okushisa aphezulu. Isibonelo, ukwengeza i-plasticizer ye-hygroscopic kungathuthukisa ubude bayo nokuguquguquka. Ukuze uthuthukise ukuguquguquka, ama-plasticizers afana ne-glycerin ne-sorbitol yiwona afaneleka kakhulu. Isixazululo esijwayelekile sihlanganisa u-2% ~ 3%, kanti inani le-plasticizer liyi-10% ~ 20% ye-cellulose ether. Uma okuqukethwe kwe-plasticizer kuphezulu kakhulu, i-shrinkage phenomenon ye-colloid dehydration izokwenzeka ngaphansi komswakama ophezulu. Amandla aqinile wefilimu ene-plasticizer eyengeziwe makhulu kakhulu kunalokho ngaphandle kwe-plasticizer, futhi ayanda ngokunyuka kwenani elingeziwe. Ngokuqondene ne-hygroscopicity yefilimu, iphinde ikhule ngokunyuka kwenani le-plasticizer.
Isikhathi sokuthumela: Oct-13-2022