I-HPMC (i-Hydroxypropyl Methylcellulose) iyisisetshenziswa se-polymer esetshenziswa kabanzi ekwembathweni nasekulungiseleleni imithi, enokwakheka okuhle kwefilimu, ukuqina, ukuzinza nokunamathela. Emkhakheni wezingubo zokugqoka, i-HPMC isetshenziswa kakhulu ezinhlelweni zokugqoka ezisekelwe emanzini, ezingathuthukisa kakhulu ukunamathela kwezingubo kanye nokusebenza kwazo jikelele.
1. Izakhiwo eziyisisekelo ze-HPMC
I-HPMC iwumphumela we-non-ionic cellulose onezici zomzimba nezekhemikhali ezihlukile. Esixazululweni, i-HPMC ingakhiqiza ukusebenzisana ngokomzimba namakhemikhali nendawo engaphansi ngamaketanga ayo amangqamuzana, ngaleyo ndlela yakhe ifilimu enamandla athile emishini nokunwebeka. Le filimu inokuguquguquka okuhle nokumelana nokuqhekeka, okungasiza ukumboza ukuthi kuzivumelanise kangcono nezici ze-substrate, ngaleyo ndlela kuthuthukiswe ukunamathela.
Indlela yokwenza ifilimu ye-HPMC ihlobene kakhulu nokuhlanganisa kanye nezici zokuxhumanisa amaketanga amangqamuzana ayo. Amaqembu e-hydroxypropyl kanye ne-methyl ku-molecule ye-HPMC ayenza ibe yi-hydrophilic ne-hydrophobic esixazululweni. Lokhu amphiphilicity kwenza i-HPMC ikwazi ukuzihlanganisa ibe yisakhiwo esiminyene ohlelweni lokumboza olusekelwe emanzini, ngaleyo ndlela ithuthukise amandla emishini nokunamathela kokunamathela.
2. Izinto ezithinta amandla okunamathela enamathela yi-HPMC
Ukugxila kwe-HPMC:
Ukuhlushwa kwe-HPMC ekunambeni kunomphumela ophawulekayo emandleni okunamathela okugqoka. Ukugxila okuphezulu kwe-HPMC kwandisa i-viscosity ye-coating futhi kuthuthukisa impahla yokwakha ifilimu, ngaleyo ndlela kuthuthukise ukunamathela kokunamathela endaweni engaphansi. Kodwa-ke, ukugxila okuphezulu kakhulu kwe-HPMC kungase kubangele ukujiya okungalingani futhi kuthinte umphumela wokunamathela. Ucwaningo luye lwabonisa ukuthi ukugxilisa okufanelekile kwe-HPMC kungabopha kangcono ukunamathela endaweni engaphansi, futhi ukugxila okuphansi kakhulu noma okuphezulu kakhulu kuzoba nomthelela omubi ekunamatheleni.
Inani le-pH nezinga lokushisa lesixazululo:
Ukunyibilika kwe-HPMC kanye nezakhiwo zayo zokwenza ifilimu kuthintwa inani le-pH nezinga lokushisa. Endaweni ene-acidic noma ene-alkali, ukuncibilika kwama-molecule e-HPMC kuyashintsha, okubuye kuthinte amandla okunamathela kokunamathela. Ngokuvamile, izimo ze-pH ezimaphakathi zingagcina ukuzinza kwe-HPMC futhi zikhuthaze ukuhlangana kwayo nendawo engaphansi. Ngaphezu kwalokho, izinga lokushisa liphinde libe nomthelela ekuhambeni kanye nesivinini sokwenza ifilimu seketango lamangqamuzana e-HPMC. Amazinga okushisa aphakeme ngokuvamile angasheshisa izinga le-volatilization yesisombululo futhi avumele ukumbozwa ukuthi kwakheke ngokushesha, kodwa kungase kwandise ukungezwani kwangaphakathi kwesendlalelo sefilimu, ngaleyo ndlela kuthinte amandla okunamathela kwengubo.
Isisindo samangqamuzana e-HPMC:
Isisindo samangqamuzana e-HPMC sithinta ngokuqondile izakhiwo zayo ze-rheological kanye nezakhiwo zefilimu ekwakhiweni. I-HPMC enesisindo esikhudlwana samangqamuzana ingakha ungqimba lwefilimu olunamandla, ngaleyo ndlela ikhulise ukunamathela kwento enamathelayo, kodwa ukuncibilika kwayo kanye ne-fluidity impofu, okungaholela kalula ekungangeni kahle kwe-coating kanye nendawo enzima. Ngokuphambene nalokho, nakuba i-HPMC enesisindo esincane samangqamuzana ine-solubility engcono kanye ne-fluidity, amandla ayo omshini ngemva kokubunjwa kwefilimu aphansi, futhi ukuthuthukiswa kwamandla okunamathela kwe-coating kunqunyelwe. Ngakho-ke, ukukhetha i-HPMC enesisindo esifanelekile se-molecular kungathinta ibhalansi phakathi kokusebenza kokunamathela nokunamathela.
Ukuqina komphumela we-HPMC:
Njenge-thickener, i-HPMC ingakhuphula kakhulu i-viscosity yesistimu ku-coating, ngaleyo ndlela ithuthukise ukuguquguquka nokufana kwe-coating. Ukwakhiwa kwesendlalelo sefilimu ewumfaniswano neminyene ebusweni be-substrate kuyisihluthulelo sokuthuthukisa amandla okunamathela, futhi i-HPMC ingavimbela ukugoqa ekugwebeni noma kumamaki okugeleza ebusweni be-substrate ngokulungisa i-viscosity ye-coating, ngaleyo ndlela. ukuqinisa ukusebenza kokunamathela kwe-coating.
3. Ukusetshenziswa kwe-HPMC kuma-substrates ahlukene
I-Metal substrates:
Ezingxenyeni zensimbi, ukunamathela kokugqoka kuvame ukuthinteka ngokushelela kwendawo yensimbi kanye nongqimba lwe-oxide. I-HPMC ithuthukisa impahla yokwakha ifilimu kanye nokuguquguquka kokumboza, okwenza ukunamathela kulingane kangcono endaweni yensimbi, kunciphise amaphutha esibonakalayo phakathi kokumboza nensimbi, ngaleyo ndlela kuthuthukiswe ukunamathela kokunamathela. Ngaphezu kwalokho, i-HPMC ingaphinda isebenze ngokubambisana namanye ama-tackifiers ukuze ithuthukise amandla omshini wokunamathela.
Ama-substrates epulasitiki:
Ama-substrates epulasitiki avame ukuba namandla aphansi angaphezulu, futhi kunzima ukuthi i-coating ibambelele ngokuqinile ezindaweni zabo. Ngenxa yesakhiwo sayo esiyingqayizivele samangqamuzana, i-HPMC ingakha amabhondi e-hydrogen aqinile endaweni yepulasitiki, ngaleyo ndlela ithuthukise ukunamathela kokunamathela. Ngasikhathi sinye, njenge-thickener, i-HPMC ingakwazi ukwenza ngcono izinga le-coating endaweni yepulasitiki futhi igweme ukuncipha noma ukuqhekeka kwento enamathelayo.
Ama-substrates e-Ceramic nengilazi:
Izindawo zezinto ezingaphili ezifana ne-ceramics nengilazi zibushelelezi kakhulu, futhi kunzima ukuthi ukunamathela kunamathele ngokuphumelelayo. I-HPMC ithuthukisa ukumanzisa nokunamathela kwento enamathelayo ebusweni balawa ma-substrates ngokusebenza njengosizo lokwenza ifilimu ekunambeni. Ngaphezu kwalokho, ikhono lokwenza ifilimu le-HPMC lingakha imifantu emincane ekhiqizwe ukumbozwa ebusweni be-substrate futhi kuthuthukise ukunamathela kukonke.
4. Imikhawulo yesicelo kanye nezikhombisi-ndlela zokuthuthukisa ze-HPMC
Nakuba i-HPMC inomthelela omkhulu ekuthuthukiseni ukunamathela kokunamathela, isenayo imikhawulo ethile ekusebenziseni okungokoqobo. Isibonelo, i-HPMC inomphumela olinganiselwe ekuthuthukiseni ukuzinza kwezingubo ezindaweni ezibucayi, ikakhulukazi ngaphansi kwezimo zomswakama ophezulu noma izinga lokushisa eliphezulu, lapho izakhiwo zayo zokwenza ifilimu zingase zehle futhi ukunamathela kujwayele ukuwa. Ngakho-ke, abacwaningi bahlola izindlela zokuqhubeka nokuthuthukisa ukusebenza kwe-HPMC ngokuguqulwa kwamakhemikhali noma ukuhlanganisa nezinye izinto ze-polymer. Isibonelo, ngokwethula ama-agent axhumanisa ama-cross-link noma ezinye izinamathiselo ezinamandla aphezulu, ukuzinza kwe-HPMC ngaphansi kwezimo ezinzima kungathuthukiswa.
Njengesengezo esibalulekile sokuhlanganisa, i-HPMC ingathuthukisa ngokuphawulekayo amandla okunamathela okunamathelayo. Izakhiwo zayo zokwenza ifilimu, izakhiwo zokuqina, nokusebenzisana ngokomzimba namakhemikhali ne-substrate surface yizici ezibalulekile emsebenzini wayo. Ngokulungisa ngokunengqondo ukugxilisa ingqondo, isisindo samangqamuzana, kanye nezimo zemvelo ze-HPMC, umphumela wayo ekuthuthukiseni ukunamathela kwezingubo zingenziwa ngcono. Ngokuzayo, ukuthuthukiswa kokusebenza kwe-HPMC kuzoletha amathuba amaningi okufaka izicelo embonini yezingubo zokumboza, ikakhulukazi emkhakheni wezingubo ezintsha ezihambisana nemvelo.
Isikhathi sokuthumela: Oct-11-2024