I-Pharmaceutical Grade Hydroxypropyl Methylcellulose (HPMC) iyisakhi semithi esetshenziswa kakhulu, esisetshenziswa kakhulu embonini yezemithi. I-semi-synthetic, inert, i-cellulose ether encibilika emanzini, eguqulwa ngamakhemikhali isuka ku-cellulose yemvelo. I-HPMC inokwakheka okuhle kwefilimu, ukuqina, ukunamathela, ukumiswa kanye nezindawo zokulwa namakhekhe, ngakho-ke inenani elibalulekile lokufaka isicelo emalungiselelweni emithi.
1. Izakhiwo eziyisisekelo ze-HPMC
I-HPMC yenziwa ngokushintsha ingxenye ye-hydroxyl ye-cellulose nge-hydroxypropyl namaqembu e-methoxy. Isakhiwo sayo samangqamuzana siqukethe izinto ezimbili, i-hydroxypropyl ne-methyl, ngakho ibizwa nge-hydroxypropyl methylcellulose. I-HPMC inokuncibilika okuhle emanzini, futhi ngemva kokuhlakazeka, yakha isisombululo se-viscous esisobala. Njengoba ukugxila kuyanda, i-viscosity nayo iyanda. Ngaphezu kwalokho, i-HPMC inokusimama okuhle kokushisa kanye nokuzinza kwamakhemikhali, futhi inokubekezelela okuhle kwezixazululo ze-asidi, i-alkali nosawoti.
2. Ukusetshenziswa kwe-HPMC kwezemithi
I-HPMC isetshenziswa kabanzi embonini yezemithi, ikakhulukazi kulezi zici ezilandelayo:
a. I-Tablet enamathela
I-HPMC, njengento yokumboza amaphilisi, ingavala ngempumelelo ukunambitheka okubi kwezidakamizwa, ithuthukise ukubukeka kwezidakamizwa, futhi ibe nemiphumela evikela umswakama kanye ne-anti-oxidation. Ngaphezu kwalokho, kungandisa isikhathi sokukhululwa kwezidakamizwa emgudwini wamathumbu, ngaleyo ndlela kuzuze imiphumela yokukhululwa eqhubekayo noma elawulwayo.
b. Ama-thickeners nama-binders
Lapho ulungiselela ukumiswa, ama-emulsions, ama-capsules namanye amalungiselelo, i-HPMC, njenge-thickener ne-binder, ingathuthukisa ukuzinza nokufana kwamalungiselelo. Ngesikhathi esifanayo, i-HPMC ingaphinda ithuthukise ubulukhuni namandla emishini yamaphilisi ukuze kuqinisekiswe ukuthi imithi ayiphuki kalula ngesikhathi sokukhiqiza nokuthuthwa.
c. Amalungiselelo okukhishwa okulawulwayo nokuqhubekayo
I-HPMC ivamise ukusetshenziselwa ukukhishwa okulawulwayo kanye namalungiselelo okukhishwa okuqhubekayo ngoba ungqimba lwejeli eyakhayo lungavimbela amanzi ukuthi angangeni kuthebhulethi, ukuze izinga lokuqedwa nokukhululwa komuthi kulawulwe ngokuphumelelayo. Ngokulungisa i-viscosity kanye nomthamo we-HPMC, izinga lokukhululwa lomuthi lingalawulwa ngokunembile, isikhathi sokusebenza somuthi singanwetshwa, futhi imvamisa yomuthi ingancishiswa.
d. Njengokugcwalisa
Emalungiselelweni we-capsule, i-HPMC ingasetshenziswa njengesigcwalisi ukugcwalisa amaphilisi angenalutho. Uma kuqhathaniswa namaphilisi e-gelatin endabuko, amaphilisi e-HPMC anezinzuzo zokutholakala kwezitshalo futhi angenazo izithako zezilwane, ngakho afanele abantu abadla imifino kanye neziguli ezinezinkolelo zenkolo.
3. Ukuphepha kwe-HPMC
Njengomsizi wezokwelapha, i-HPMC inokuvumelana okuhle kwe-biocompatibility nokuphepha. Ayiboliswa ngama-enzyme okugaya emzimbeni womuntu futhi ikhishwa ikakhulukazi emzimbeni ngokusebenzisa amathumbu, ngakho ayihlanganyeli enqubweni ye-metabolism yezidakamizwa futhi ayikhiqizi imiphumela emibi enobuthi. I-HPMC isetshenziswe kabanzi emalungiselelweni ahlukahlukene omlomo, ama-topical kanye nemijovo futhi ibonwa yi-pharmacopoeias emhlabeni jikelele.
4. Amathemba emakethe
Ngokuthuthuka okuqhubekayo kwemboni yezemithi, izidingo zekhwalithi nokuphepha kwezidakamizwa nazo ziyanda. Ngenxa yezakhiwo zayo ezihlukile zomzimba namakhemikhali kanye nokuphepha okuhle, i-HPMC inethuba elibanzi lokusebenzisa amalungiselelo emishanguzo emisha. Ikakhulukazi emikhakheni yokulungiselela ukukhishwa okulawulwayo kanye nokukhululwa okuqhubekayo, izidakamizwa zebhayoloji kanye nemithi yabantu abakhethekile (njengabadla imifino), isidingo se-HPMC sizoqhubeka sikhula.
Njengomsizi wemithi osebenza ngezinto eziningi, i-hydroxypropyl methylcellulose yezinga lezemithi ibambe iqhaza elibalulekile embonini yezemithi futhi izoqhubeka nokusetshenziswa kabanzi futhi ithuthukiswe esikhathini esizayo.
Isikhathi sokuthumela: Aug-06-2024