Ingabe i-HPMC iyenziwa noma yemvelo?

IHydroxypropylmethylcellulose (HPMC) iyinhlanganisela eguquguqukayo futhi eguquguqukayo esebenza kuzo zonke izimboni ezahlukahlukene. Ukuze uqonde ingqikithi yayo, umuntu kufanele ahlole izithako zayo, izinqubo zokukhiqiza, kanye nemvelaphi.

Izithako ze-HPMC:
I-HPMC i-semi-synthetic polymer etholakala ku-cellulose, i-polysaccharide yemvelo etholakala ezindongeni zamaseli ezitshalo. Umthombo oyinhloko we-cellulose yi-pulp yokhuni noma i-cotton fiber. Ukwenziwa kwe-HPMC kuhilela ukulungisa i-cellulose ngochungechunge lokusabela kwamakhemikhali ukuze kube okuphuma ku-cellulose.

Izici zokwenziwa kokukhiqizwa kwe-HPMC:
Inqubo ye-Etherification:

Ukukhiqizwa kwe-HPMC kubandakanya ukufakwa kwe-cellulose etherification nge-propylene oxide ne-methyl chloride.
Phakathi nale nqubo, amaqembu e-hydroxypropyl kanye ne-methyl angeniswa kumgogodla we-cellulose, akha i-HPMC.

Ukuguqulwa kwamakhemikhali:

Ukuguqulwa kwamakhemikhali okwethulwa ngesikhathi sokuhlanganiswa kuholela ekutheni i-HPMC ihlukaniswe njengenhlanganisela yokwenziwa kancane.
I-Degree of substitution (DS) ibhekisela enanini elimaphakathi le-hydroxypropyl namaqembu e-methyl ngeyunithi ngayinye ye-glucose ochungechungeni lwe-cellulose. Leli nani le-DS lingalungiswa phakathi nenqubo yokukhiqiza ukuze kutholwe i-HPMC enezakhiwo ezithile.

Ukukhiqizwa kwezimboni:

I-HPMC ikhiqizwa ngokwezimboni ngezinga elikhulu izinkampani ezimbalwa zisebenzisa ukusabela kwamakhemikhali okulawulwayo.
Inqubo yokukhiqiza ibandakanya izimo eziqondile zokufeza izakhiwo ezifiselekayo kanye nokusebenza komkhiqizo wokugcina.

Imithombo yemvelo ye-HPMC:
I-Cellulose njengomthombo wemvelo:

I-Cellulose iyinto eyisisekelo ye-HPMC futhi inondala ngokwemvelo.
Izitshalo, ikakhulukazi ukhuni nokotini, ziyimithombo ecebile ye-cellulose. Ukukhishwa kwe-cellulose kule mithombo yemvelo kuqala inqubo yokukhiqiza ye-HPMC.

I-Biodegradability:

I-HPMC iyakwazi ukubola, impahla yezinto eziningi zemvelo.
Ukuba khona kwe-cellulose yemvelo ku-HPMC kunomthelela ezintweni zayo ezibolayo, okuyenza ivumelane nemvelo ezinhlelweni ezithile.

Izicelo ze-HPMC:
umuthi:

I-HPMC isetshenziswa kakhulu embonini yezemithi njengama-ejenti okugcoba, izibophezelo kanye no-matrics abakhululwa okuqhubekayo ekwakhiweni kwamathebulethi. I-biocompatibility yayo kanye nezakhiwo zokukhululwa ezilawulwayo ziyenza ibe ukukhetha kokuqala kumasistimu okulethwa kwezidakamizwa.

Imboni yezokwakha:

Ekwakhiweni, i-HPMC isetshenziswa njenge-ejenti yokugcina amanzi, i-thickener, kanye nokulawula isikhathi ezintweni ezisekelwe kusimende. Indima yayo ekwenzeni ngcono ukusebenza kanye nokunamathela kodaka namapulasi ibalulekile.

imboni yokudla:

I-HPMC isetshenziswa njenge-ejenti yokuqina kanye ne-gelling embonini yokudla.
Ivame ukusetshenziswa emikhiqizweni yokudla efana namasoso, amasobho kanye nezinto ezibhakwayo.

izimonyo:

Kwezimonyo, i-HPMC itholakala emikhiqizweni eyahlukene okuhlanganisa okhilimu, izinto zokuthambisa, namajeli, asebenza njengamajiya, ama-stabilizer, nama-emulsifiers.

Izicelo zezimboni:

Ukuguquguquka kwe-HPMC kudlulela ezinhlobonhlobo zezinhlelo zokusebenza zezimboni, okuhlanganisa ukwakhiwa kopende, izinto zokunamathisela kanye nokucubungula izindwangu.

Isimo sokulawula:
Isimo se-GRAS:

E-United States, i-HPMC ngokuvamile ibonwa njengephephile (GRAS) kwezinye izinhlelo zokusebenza ekudleni yi-US Food and Drug Administration (FDA).

Izindinganiso zezidakamizwa:

I-HPMC esetshenziswa emikhiqizweni yezemithi kufanele ihambisane namazinga ekhemisi afana ne-United States Pharmacopeia (USP) kanye ne-European Pharmacopoeia (Ph. Eur.).

Ekuphetheni:
Kafushane, i-hydroxypropyl methylcellulose (HPMC) i-semi-synthetic polymer etholakala ku-cellulose yemvelo ngenqubo yokuguqulwa kwamakhemikhali elawulwayo. Nakuba iye yaba nenguquko ephawulekayo yokwenziwa, imvelaphi yayo isezisetshenziswa zemvelo ezifana ne-wood pulp nokotini. Izakhiwo eziyingqayizivele ze-HPMC ziyenza ibe yinhlanganisela ebalulekile esetshenziswa kabanzi kwezemithi, ukwakhiwa, ukudla, izimonyo kanye nezimboni ezihlukahlukene. Inhlanganisela ye-cellulose yemvelo kanye nokuguqulwa kokwenziwa kunomthelela ekusebenzisaneni kwayo ngezindlela eziningi, ukubola kwe-biodegradability kanye nokwamukelwa kokulawula emikhakheni ehlukene.