Ingabe i-HPMC iyi-hydrogel?

IHydroxypropyl methylcellulose (HPMC) iyi-polymer eguquguqukayo esetshenziswa ezimbonini ezahlukahlukene ngenxa yezakhiwo zayo ezihlukile. Nakuba ingasetshenziswa ukwenza ama-hydrogel ngaphansi kwezimo ezithile, akuyona i-hydrogel ngokwayo.

1. Isingeniso ku-HPMC:

IHydroxypropyl methylcellulose (HPMC) i-semi-synthetic polymer etholakala ku-cellulose, i-polymer yemvelo etholakala ezindongeni zamaseli ezitshalo. Ihlanganiswa ngokwelapha i-cellulose nge-alkali bese isabela nge-propylene oxide ne-methyl chloride. I-polymer ewumphumela ikhombisa uhla lwezakhiwo ezenza ibaluleke ezimbonini ezahlukahlukene, kufaka phakathi ezemithi, ukudla, izimonyo, nezokwakha.

2. Izakhiwo ze-HPMC:

I-HPMC inezinto eziningi ezinenzuzo:

a. Ukunyibilika kwamanzi:

I-HPMC iyancibilika emanzini, yakha izixazululo ze-viscous. Lesi sakhiwo siwusizo ikakhulukazi kwezemithi, lapho singasetshenziswa khona ukudala ukumiswa, ama-emulsions, kanye nokwakhiwa kwezidakamizwa ezikhishwa okulawulwayo.

b. Ikhono Lokwenza Ifilimu:

I-HPMC ingakha amafilimu aguquguqukayo nasobala lapho esakazwa ezixazululweni zayo ezinamanzi. Lawa mafilimu athola izinhlelo zokusebenza kuma-coatings amaphilisi, amaphilisi, namafilimu omlomo.

c. I-Rheology Modifier:

I-HPMC isebenza njenge-thickener ne-rheology modifier ezixazululweni ezinamanzi. I-viscosity yayo ingalungiswa ngokulungisa izici ezifana nesisindo samangqamuzana kanye nezinga lokushintshwa.

d. I-Biocompatibility:

I-HPMC iyahambelana nezinto eziphilayo futhi ayinabo ubuthi, okuyenza ifanelekele ukusetshenziswa emikhiqizweni yezemithi, yezimonyo, neyokudla.

3. Izicelo ze-HPMC:

I-HPMC ithola izinhlelo zokusebenza ezisabalele kuzo zonke izimboni ezahlukahlukene:

a. Ezemithi:

Ekwakhekeni kwemithi, i-HPMC isetshenziswa njenge-binder, i-disintegrant, i-ejenti yokumboza ifilimu, kanye ne-matrix ekhishwa okuqhubekayo. Ithuthukisa ubuqotho bethebhulethi, ilawula ukukhishwa kwezidakamizwa, futhi ithuthukise ukuthobela kwesiguli.

b. Imboni Yokudla:

Embonini yezokudla, i-HPMC iqashwe njenge-thickener, emulsifier, stabilizer, kanye ne-ejenti ye-gelling. Inomthelela ekwakhiweni, i-viscosity, kanye nokuzinza kwemikhiqizo yokudla njengamasoso, okokugqoka, nama-dessert.

c. Izimonyo:

I-HPMC isetshenziswa kuzimonyo nemikhiqizo yokunakekelwa komuntu siqu njenge-thickener, i-ejenti elengayo, eyake yaba yifilimu, kanye ne-emulsifier. Inikeza izici ezifiselekayo ze-rheological kokhilimu, ama-lotions, nama-gel ngenkathi ithuthukisa ukuzinza kanye nezimfanelo zezinzwa.

d. Ukwakha:

Embonini yezokwakha, i-HPMC isetshenziswa ezintweni zikasimende njenge-ejenti yokugcina amanzi, isithuthukisi sokusebenza, kanye ne-ejenti yokuqina. Ithuthukisa izici zodaka kanye ne-plaster, njengokunamathela, ukubumbana, nokumelana ne-sag.

4. Ukwakhiwa kweHydrogel nge-HPMC:

Nakuba i-HPMC ngokwayo ingeyona i-hydrogel, ingabamba iqhaza ekwakhekeni kwe-hydrogel ngaphansi kwezimo ezifanele. I-hydrogel iyinethiwekhi yamaketanga e-polymer ekwazi ukumunca futhi igcine amanzi amaningi. Ukwakhiwa kwama-hydrogel e-HPMC ngokuvamile kuhilela ukuxhumanisa amaketanga e-polymer ukuze kwakhiwe inethiwekhi enezinhlangothi ezintathu ekwazi ukumunca amanzi.

a. Ama-Crosslinking Agents:

Ama-Crosslinking agents afana ne-glutaraldehyde, i-genipin, noma izindlela ezingokomzimba ezifana nemijikelezo yokuncibilika kweqhwa zingase zisetshenziswe ukuphambanisa amaketanga e-HPMC. Lokhu kuxhumanisa kuholela ekwakhekeni kwenethiwekhi ye-hydrogel ngaphakathi kwe-matrix ye-HPMC.

b. Ukuziphatha Ukuvuvukala:

Izakhiwo ze-hydrogel ze-HPMC zingalungiswa ngokulungisa izici ezifana nezinga lokushintshwa, isisindo samangqamuzana, kanye nokuminyana okuxhumanisayo. Amazinga aphezulu okushintshanisa nezisindo zamangqamuzana ngokuvamile aholela ekwandeni kwamakhono okuvuvukala kwe-hydrogel.

c. Izicelo ze-HPMC Hydrogels:

Ama-hydrogel e-HPMC athola ukusetshenziswa ekulethweni kwezidakamizwa, ukuphulukiswa kwamanxeba, ubunjiniyela bezicubu, namalensi okuxhumana. I-biocompatibility yabo, izakhiwo eziguqulekayo, kanye nekhono lokugcina amanzi kubenza bafanelekele ukusetshenziswa okuhlukahlukene kwe-biomedical.

I-HPMC iyi-polymer eguquguqukayo enezinhlelo zokusebenza ezahlukahlukene kuyo yonke imithi, ukudla, izimonyo, nezimboni zokwakha. Yize ingeyona i-hydrogel ngokwemvelo, ingabamba iqhaza ekwakhiweni kwe-hydrogel ngokuxhumanisa amaketango ayo e-polymer. Ama-hydrogel e-HPMC avelayo abonisa izakhiwo ezifana nokumunca nokugcinwa kwamanzi, okuwenza abe wusizo ezinhlelweni ze-biomedical. Njengoba ucwaningo luqhubeka nokuhlola ukusetshenziswa kwenoveli nokwakhiwa kwe-HPMC, ukubaluleka kwayo ezimbonini ezahlukahlukene kulindeleke ukuthi kuqhubeke ukwanda.