I-Hydroxypropyl methylcellulose (HPMC)I-polymenckal anymel anymer asetshenziswa kabanzi emikhakheni yokwakha, umuthi, izimonyo, ukudla kukaPetroleum. Kususelwa kwisitshalo semvelo se-cellulose futhi kutholakala ngokusabela kokuguqulwa kwamakhemikhali. Ine-solubity enhle yamanzi, ukuqina, amafilimu okwakha kanye nokunamathela. Ukukhiqizwa kwezimboni kweKimacell®HPMC ikakhulukazi kufaka phakathi ukulungiswa kokuguqulwa kweselula. Ukuphendula okujwayelekile kokuguqulwa kufaka i-methylation ne-hydroxypropylation.
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Izinto zokwenziwa kwe-Cellulose: Ukukhiqizwa kwe-HPMC kuqala nge-cellulose yemvelo. Imithombo ejwayelekile ifaka imicu yezitshalo enjenge-soni upulpiti, ukotini, kanye ne-hemp. Ukuze uqinisekise inqubekela phambili ebushelelezi yokuphendula okulandelayo, i-cellulose imvamisa idinga ukwenziwa sengathi isusa ukungcola futhi yandise umsebenzi wokuphendula.
Izinyathelo zokuhlekisa
2. Inqubo ye-synthesis ye-HPMC
Inqubo yokuhlanganiswa kwe-HPMC ikakhulukazi ifaka phakathi kwe-methylation kanye ne-hydroxypropylation ukusabela, okwenziwa ngaphansi kwezimo ze-alkali. Inqubo ethile yokukhiqiza ifaka izinyathelo ezilandelayo:
Ukwenza kusebenze i-cellulose: Ukuze wenze kube lula ukuphendula ngamakhemikhali, kuvame ukudingekile ukwelapha iselula nge-alkaline solution efana ne-sodium hydroxide (NAOH) ukuthola i-matrix evuvukala. Kulesi sigaba, i-crystaltaltity ye-celtuleose iyancipha futhi isakhiwo siba ruser, okuwusizo ekuguqukeni kwamakhemikhali okulandelayo.
I-Methylation reaction: Ukusabela kwe-methylation kuguqula iqembu le-cellulose ngokwazisa iqembu le-methyl (-ch₃). Ama-methylating asetshenziswa kakhulu ama-methylating agents yi-methyl chloride (ch₃cl) noma i-chloroform (chcl₃). Ekhoneni likaSodium Hydroxide, i-methylating ejenti iphendula nge-cellulose yokubuyisela amanye amaqembu ama-hydroxyl (-OH) kwi-cellulose molecule ngamaqembu we-mettyl (-ch₃), ngaleyo ndlela akha i-methyl cellulose.
Ukusabela kwe-Hydroxypropylation: Ngemuva kokuthi i-methylation isiqediwe, i-propelly oxide (PO) ivame ukusetshenziswa njenge-activation ukwethula iqembu le-hydroxypropyll (-ch₂ch (oh) CH₃). Ukusabela kwenziwa ngaphansi kwezimo ze-alkaline. Ukusabela kwe-hydroxyproppyration kuthatha indawo amanye amaqembu we-methoxy kuma-molecule we-cellulose ngamaqembu we-hydroxypropyl, ngaleyo ndlela akha i-HPMC.
Ukulawula Ukuphendula: Ngeyo yonke inqubo yokuphendula, izinga lokushisa, isikhathi kanye nezilinganiso zokuphendula kudingeka zilawulwe ngokunembile ukuze kuqinisekiswe ukuthi isisindo se-tydylypropylication kanye ne-degree methylation ye-kimacell®HPMC zihlangabezana nezidingo zomkhiqizo. Ngokuvamile, izinga lokushisa elisheshayo lilawulwa phakathi kuka-30 no-80 ° C, futhi isikhathi sokuphendula sisuka emahoreni ambalwa kuya ngaphezulu kwamahora ayishumi.
Ukungathathi hlangothi nokuhlanzwa: Ngemuva kokuphelelwa yisikhathi, umkhiqizo udinga ukungathathi hlangothi futhi uhlanzwe, imvamisa ngokungeza acid (njenge-acetic acid, njll.) Ukubandakanya izinto eziningi ze-alkaline. Izinyathelo zokuhlanza zibandakanya ukugeza, ukuhlunga, ukomisa nezinye izinqubo ukususa izinto ezingafakwanga ezingafakwanga, izixazululo nemikhiqizo.
3. Ukomisa umkhiqizo kanye nokupakisha
Ukomisa: I-HPMC ehlanziwe ivame ukuba khona ngesimo se-powder engenawo amanzi, futhi umswakama kufanele ususwe ngokomiswa kwesifutho, ukomisa nezinye izindlela. Umkhiqizo omisiwe kufanele alondoloze umswakama ophansi, uvame ukulawulwa ngaphansi kwe-5%, ukuvikela umkhiqizo ukuthi unamathele nasekuhlolweni.
Ukupakishwa: I-HPMC eyomile ifakwe ngefomu le-powder, futhi inqubo yokupakisha idinga ukwelashwa kobufakazi bokuma umswakama. Imvamisa ifakwe ezikhwameni ze-polyethylene, izikhwama zamaphepha noma izikhwama eziyinhlanganisela zokuhamba okulula nokugcinwa.
4. Ukulawulwa kwekhwalithi kanye namazinga omkhiqizo
Enqubweni yokukhiqiza ye-HPMC, ukulawula kwekhwalithi okuqinile kubalulekile. Ikhwalithi ye-HPMC incike hhayi kwikhwalithi yezinto zokwakha, kepha futhi nasezintweni ezifana nezimo zokuphendula nezinqubo zokufaka. Abakhiqizi bavame ukwenza ukuhlolwa kwekhwalithi ngokuya ngamazinga aphesheya kanye nesifunda. Izinkomba ezijwayelekile zekhwalithi zifaka:
I-Solubinity: I-HPMC kufanele ibe ne-solubility enhle yamanzi, futhi i-solubity kanye nezinga lokuchithwa kudinga ukufeza izidingo ezicacisiwe.
I-Viscosity: I-viscosity ye-HPMC ithinta ngqo umphumela wohlelo lokusebenza, futhi imikhiqizo ehlukene inezidingo ezihlukile ze-viscosity. Izindlela ezijwayelekile zokuhlola izibonelelo zifaka indlela ye-Brookfield Viscosity.
Ukuhlanzeka kanye nokungcola: Okuqukethwe kokungcola emikhiqizweni ye-HPMC kufanele kulawulwe ngaphakathi kobubanzi obucacisiwe ukuze kuqinisekiswe ubumsulwa obuphezulu bomkhiqizo.
Ubukhulu bezinhlayiyana: Kuya ngezidingo zezinkambu zohlelo lokusebenza ezihlukile, ubukhulu bezinhlayiyana ze-HPMC bangahlukahluka, futhi i-powder enhle noma imikhiqizo ye-granur izoba nezimo ezihlukile zohlelo lokusebenza.
5. Izinkambu zohlelo lokusebenza lwe-HPMC
I-HPMC isetshenziswa kabanzi kwizimboni eziningi futhi inenani elibalulekile lezentengiso.
Imboni Yokwakha: I-HPMC isetshenziswa kabanzi njenge-ejenti enkulu kanye ne-ejenti yokugcina amanzi ezintweni zokwakha ezinjengesimende kasimende, udaka olomile kanye namathayili anamathela, okungathuthukisa ukusebenza kokwakha kanye nokugcinwa kwamanzi kwezinto zokwakha.
Imboni yezemithi: I-HPMC inezicelo ezibalulekile emkhakheni wezemithi njengama-capsule amagobolondo, ukunamathela kwethebhulethi kanye nezithwali zezidakamizwa ezilawulwayo.
Imboni yokudla: ekudleni, i-HPMC isetshenziswa njengesikhudlwana, i-stabilizer, emulsifier, njll, esingathuthukisa ukuthungwa nokunambitheka kokudla.
Imboni yezimonyo: I-HPMC isetshenziswa njenge-ejenti enkulu nefilimu eyakha izimonyo, futhi isetshenziswa ekwenziweni kwemikhiqizo efana ne-lotion nokhilimu.
Ezinye izinkambu: I-KimaCell®HPMC nayo isetshenziswa kabanzi ezimbonini ezinjenge-petroleum, izindwangu, ephepheni, kanye nezimbobo.
Ukukhiqizwa kwezimboni kweI-HPMCIguqula i-cellulose yemvelo ibe yingxenye ye-polymer encibilikayo yamanzi enezakhiwo ezisebenzayo ngochungechunge lokuphendula kokuguqulwa kwamakhemikhali. Ngokulawula ngokunembile izimo zokuphendula nezinqubo zokwelashwa kwangemva kokulashwa, imikhiqizo ye-HPMC ehlangabezana nezidingo zohlelo lokusebenza ezihlukile zingatholakala. Ngohlelo lokusebenza olusakazekile lwe-HPMC, ucwaningo oluthe xaxa kanye nokwengeziwe kwezobuchwepheshe kuzoqhubeka ukukhuthaza ukuthuthuka kwenqubo yalo yokukhiqiza kanye nekhwalithi yomkhiqizo.
Isikhathi Sokuposa: Jan-27-2025