I-Hypromellose - Isakhi semithi yendabuko

IHypromellose, eyaziwa nangokuthi i-hydroxypropyl methylcellulose (HPMC), iyisakhi yendabuko yemithi esetshenziswa kabanzi embonini yezemithi ngezinjongo ezahlukahlukene. Ingokwesigaba se-cellulose ethers futhi isuselwa ku-cellulose, i-polymer yemvelo etholakala ezindongeni zamaseli ezitshalo. IHypromellose ihlanganiswa ngokwelapha i-cellulose nge-propylene oxide ne-methyl chloride.

Nazi ezinye izici ezibalulekile nezindima ze-hypromellose njenge-excipient yezemithi:

1. Isibopho: I-Hypromellose ivamise ukusetshenziswa njengesihlanganisi ekwakhiweni kwethebhulethi. Kuyasiza ukuhlanganisa izithako zemithi esebenzayo (ama-API) kanye nezinye izinto ezisizayo ndawonye, ​​ukuqinisekisa ukuthi ithebhulethi igcina isimo sayo nobuqotho ngesikhathi sokukhiqiza nokuphatha.
2. I-Film Coating Agent: I-Hypromellose isetshenziswa njenge-ejenti yokuhlanganisa ifilimu ukuze inikeze ukunamathela okuvikelekile nokubushelelezi kumaphilisi namaphilisi. Lokhu kugcotshwa kungafihla ukunambitheka okungajabulisi, ukuthuthukisa ukubukeka, ukuvikela umswakama, nokulawula ukukhishwa kwesidakamizwa.
3. I-Matrix Yangaphambili: Ekwenziweni kokukhishwa okuqhubekayo, i-hypromellose ingasetshenziswa njenge-matrix yangaphambili. Yakha i-matrix efana nejeli lapho ithintana namanzi, ilawula ukukhululwa komuthi isikhathi eside, ngaleyo ndlela inikeze isenzo sesidakamizwa eside.
4. I-Viscosity Modifier: I-Hypromellose ivamise ukuqashwa ukuze kulungiswe i-viscosity yezinto eziwuketshezi ezifana nokumiswa komlomo kanye nokulungiswa kwezihloko. Kuyasiza ukuzinzisa ukumiswa, ukulawula i-rheology, futhi kuthuthukise ukuthululwa nokusabalala.
5. I-Disintegrant: Kwezinye izimo, i-hypromellose ingasebenza njenge-disintegrant, ikhuthaze ukuhlukana okusheshayo kwamaphilisi noma amaphilisi abe yizinhlayiya ezincane lapho evezwe emanzini emgudwini wamathumbu, ngaleyo ndlela kube lula ukuchithwa kwezidakamizwa nokumuncwa.
6. I-Emulsifier ne-Stabilizer: I-Hypromellose ingasebenza njenge-emulsifying agent kanye ne-stabilizer kuma-emulsions nama-creams, isiza ukudala ukwakheka okuzinzile nokufana okufanayo kokusetshenziswa kwezihloko.
7. I-Mucoadhesive: Ekwakhekeni kwe-ocular noma izifutho zekhala, i-hypromellose ingasebenza njenge-ejenti ye-mucoadhesive, ikhuthaze ukunamathela ezindaweni ezingaphansi kwe-mucosal futhi yandise isikhathi sokuxhumana somuthi ngezicubu ezihlosiwe.

Sekukonke, i-hypromellose iyisakhi semithi esisebenza ngezindlela eziningi esaziswa nge-biocompatibility yayo, ukungabi nabuthi, kanye nohlu olubanzi lwezinhlelo zokusebenza kumafomu omthamo njengamaphilisi, amaphilisi, amafilimu, okokumiswa, nokhilimu. Izakhiwo zayo ziyenza ibe yingxenye ebalulekile ekwakhiweni kwemikhiqizo ehlukahlukene yemithi, enomthelela ekusebenzeni kwayo, ukuzinza, nokwamukeleka kwesiguli.