I-Hydroxypropyl methylcellulose ukulahlekelwa isisindo

Isingeniso

IHydroxypropyl methylcellulose (HPMC) isetshenziswa kabanzi embonini yokudla, ekhemisi nasezimbonini zezimonyo. I-polymer encibilikayo emanzini, engeyona i-ionic, futhi ebolayo etholakala ku-cellulose. I-HPMC isetshenziswe iminyaka eminingi njenge-ejenti yokuqina, i-emulsifier, i-stabilizer, kanye ne-ejenti yokugaya emikhiqizweni yokudla ehlukahlukene. Eminyakeni yamuva, kutholakale ukuthi kunezinhlelo zokusebenza ezingase zibe khona ekulahlekelweni kwesisindo.

Indlela Yokwenza

I-HPMC iyi-polymer eyi-hydrophilic ekwazi ukumunca amanzi futhi ikhukhumale yakhe ijeli. Lesi sakhiwo esifana nejeli kucatshangwa ukuthi sinomthwalo wemfanelo waso sokunciphisa isifiso sokudla futhi sikhuthaze ukusutha. Kukholakala ukuthi isakhiwo esifana nejeli se-HPMC sakha umgoqo ongokomzimba esiswini, obambezela ukumuncwa kokudla futhi andise umuzwa wokugcwala. Ukwengeza, i-HPMC kucatshangwa ukuthi inciphisa ukumuncwa kwamafutha nama-carbohydrate, okungaholela ekulahlekelweni kwesisindo.

Ubufakazi Bomtholampilo

Kube khona izifundo zomtholampilo ezimbalwa ezihlole imiphumela ye-HPMC ekunciphiseni isisindo. Ocwaningweni olungahleliwe, olungaboni kabili, olulawulwa yi-placebo, izifundo zanikezwa i-HPMC noma i-placebo amasonto ayisishiyagalombili. Ekupheleni kocwaningo, izihloko ezazithathe i-HPMC zase zehle kakhulu isisindo kunalabo ababethathe i-placebo. Kolunye ucwaningo, izifundo zanikezwa i-HPMC noma i-placebo amasonto ayi-12. Ekupheleni kocwaningo, izihloko ezazithathe i-HPMC zazilahlekelwe kakhulu isisindo kunalezo ezazithathe i-placebo.

Ngaphezu kwalezi zifundo, kube nezinye izifundo ezimbalwa eziye zahlola imiphumela ye-HPMC ekulahlekelweni kwesisindo. Ocwaningweni olungahleliwe, olungaboni kabili, olulawulwa yi-placebo, izifundo zanikezwa i-HPMC noma i-placebo amasonto ayisishiyagalombili. Ekupheleni kocwaningo, izihloko ezazithathe i-HPMC zazilahlekelwe kakhulu isisindo kunalezo ezazithathe i-placebo.

Ukuphepha

I-HPMC ngokuvamile ibhekwa njengephephile ukuthi isetshenziswe abantu. Ngokuvamile kubekezelelwa kahle futhi kunemiphumela emibi embalwa. Imiphumela emibi evamile ebikiwe ukuphatheka kabi kwesisu, njengokucanuzela kwenhliziyo, ukuhlanza, kanye nesifo sohudo. Ukwengeza, i-HPMC ingase ihlanganyele nemithi ethile, ngakho-ke kubalulekile ukubonisana nomhlinzeki wezempilo ngaphambi kokuthatha i-HPMC.

Isiphetho

IHydroxypropyl methylcellulose (HPMC) isetshenziswa kabanzi embonini yokudla, ekhemisi nasezimbonini zezimonyo. Kutholakale ukuthi kunezinhlelo zokusebenza ezingase zibe khona ekunciphiseni isisindo, njengoba kukholakala ukuthi kwakha umgoqo womzimba esiswini futhi kunciphise ukumuncwa kwamafutha nama-carbohydrate. Ucwaningo oluningana lwemitholampilo luhlole imiphumela ye-HPMC ekuncipheni kwesisindo, futhi imiphumela iye yathembisa. I-HPMC ngokuvamile ibhekwa njengephephile ukuthi isetshenziswe abantu, nakuba ingase ihlanganyele nemithi ethile.