IHydroxypropylmethylcellulose (HPMC) iyi-polymer eguquguqukayo esetshenziswa ezimbonini ezahlukahlukene, kufaka phakathi ezemithi, ezokwakha, ukudla, nezimonyo. Enye yezinhlelo zayo ezivamile ekwakhiweni kwemikhiqizo yejeli. Ama-gel ayizinhlelo ze-semisolid ezinezakhiwo eziyingqayizivele ze-rheological, futhi ukusebenza kwazo kungathinteka yizici ezihlukahlukene, kuhlanganise nezinga lokushisa.
ethula
IHydroxypropylmethylcellulose (HPMC) iphuma ku-cellulose ehlanganiswe ngokwelapha i-cellulose nge-propylene oxide ne-methyl chloride. Ingowomndeni we-cellulose ether futhi inendawo encibilikayo emanzini kanye ne-gelling. I-HPMC isetshenziswa kakhulu embonini yezemithi, yokudla, yokwakha kanye nezimonyo ngenxa yamakhono ayo amahle kakhulu okwenza ifilimu, ukuqina kanye namakhono okugaya.
Ukufakwa kwe-HPMC
I-Gelation inqubo lapho uketshezi noma i-sol ishintsha ibe ijeli, isimo esiqinile esinakho kokubili izinto eziwuketshezi neziqinile. I-HPMC ijeli ngokusebenzisa indlela yokukhipha amanzi kanye nokwakheka kwenethiwekhi enezinhlangothi ezintathu. Inqubo ye-gelation ithintwa yizici ezifana nokugxila kwe-polymer, isisindo samangqamuzana nokushisa.
Ukuncika kwezinga lokushisa kwe-gelation
Izinga lokushisa lidlala indima ebalulekile ekuziphatheni kwe-gelation ye-HPMC. Ubudlelwano phakathi kwezinga lokushisa ne-gelation bungaba yinkimbinkimbi, futhi kubalulekile ukuqonda ukuthi izinguquko kuzinga lokushisa zithinta kanjani izakhiwo zamajeli e-HPMC. Ngokuvamile, i-gelation ye-HPMC iyinqubo ye-exothermic, okusho ukuthi ikhulula ukushisa.
1. Uhlolojikelele lwamajeli ashisayo
Amajika okushisa ashisayo e-HPMC abonakala ngebanga lokushisa le-gelation, okungukuthi ububanzi bezinga lokushisa lapho ukuguquka kusuka ku-sol kuya kujeli kwenzeka. Izinga lokushisa le-gelation lithintwa ukuhlushwa kwe-HPMC esixazululweni. Ukugxila okuphezulu ngokuvamile kubangela amazinga okushisa aphezulu e-gelling.
2. Umphumela ku-viscosity
Izinga lokushisa lithinta i-viscosity yesisombululo se-HPMC futhi ngaleyo ndlela inqubo ye-gelation. Njengoba izinga lokushisa likhuphuka, i-viscosity yesisombululo se-HPMC iyancipha. Ukunciphisa i-viscosity kuthinta amandla e-gel kanye nezakhiwo zokugcina ze-gel. Izinga lokushisa kufanele lilawulwe ngokucophelela futhi liqashwe ngesikhathi sokubunjwa ukuze kuzuzwe i-viscosity oyifunayo kanye nezakhiwo zejeli.
Izinto ezithinta izinga lokushisa lejeli
Izinto ezimbalwa zithonya izinga lokushisa lejeli le-HPMC, futhi ukuqonda lezi zici kubalulekile kubaqulunqi nabacwaningi.
1. Ukugxila kwe-polymer
Ukugxila kwe-HPMC kufomula kuyisici esibalulekile esithinta izinga lokushisa le-gelation. Ukugxila okuphezulu ngokuvamile kubangela amazinga okushisa aphezulu e-gelation. Lobu budlelwano bubangelwa ukwanda kwenani lamaketanga e-polymer atholakalayo ukuze kusetshenziswe ama-intermolecular, okuholela kunethiwekhi yejeli enamandla.
2. Isisindo samangqamuzana e-HPMC
Isisindo samangqamuzana e-HPMC siphinde sithinte i-gelation. Isisindo samangqamuzana aphezulu i-HPMC ingase ibonise amazinga okushisa ejeli ahlukene uma kuqhathaniswa nesisindo samangqamuzana esiphansi se-HPMC. Isisindo samangqamuzana sithinta ukunyibilika kwe-polymer, ukuthandelwa kweketango, namandla enethiwekhi yejeli eyakhiwe.
3. Izinga lokukhipha amanzi
I-HPMC hydration rate ithintwa izinga lokushisa. Amazinga okushisa aphakeme asheshisa inqubo ye-hydration, okuholela ku-gelation esheshayo. Lokhu kubaluleke kakhulu ekwakhiweni okuzwela isikhathi okudinga i-gelation esheshayo.
4. Ukuba khona kwezithasiselo
Ukuba khona kwezithasiselo ezifana nama-plasticizers noma usawoti kungashintsha izinga lokushisa le-gelling le-HPMC. Lezi zengezo zingasebenzisana namaketanga e-polymer, zithinte amandla azo okwenza amanethiwekhi ejeli. Abaqulunqi kufanele bacabangele ngokucophelela umphumela wezithasiselo ekuziphatheni kwejeli.
Ukubaluleka okusebenzayo kanye nezicelo
Ukuqonda ukuziphatha kwejeli encike kumazinga okushisa ye-HPMC kubalulekile ekwenzeni imikhiqizo enekhwalithi nokusebenza okungaguquki. Lokhu kuqonda kuveza imithelela eminingi esebenzayo kanye nezicelo.
1. Izidakamizwa ezikhululayo ezilawulwayo
Embonini yezemithi, i-HPMC ivamise ukusetshenziswa ekwakhiweni kwemithi ekhishwa okulawulwayo. Ukuzwela kwezinga lokushisa kwamajeli e-HPMC kungasetshenziswa ukulawula ukukhishwa kwezithako ezisebenzayo zemithi. Ngokulungisa ngokucophelela izinga lokushisa le-gelation, abaklami bangakwazi ukuhlanganisa amaphrofayili okukhululwa kwezidakamizwa.
2. Ama-hydrogel aphendula izinga lokushisa
Ukuzwela kwezinga lokushisa kwe-HPMC kuyenza ifaneleke ukwakhiwa kwama-hydrogel asabelayo kukushisa. Lawa ma-hydrogel angakwazi ukushintshela emuva ekushintsheni kwejeli ye-sol-gel ekuphenduleni izinguquko ezingeni lokushisa, okuwenza abe wusizo ekusetshenzisweni okufana nokuphulukiswa kwesilonda nokulethwa kwezidakamizwa.
3. Izinto zokwakha
Embonini yezokwakha, i-HPMC ivamise ukusetshenziswa njengesengezo ezintweni ezisekelwe kusimende ukuthuthukisa ukusebenza nokugcinwa kwamanzi. Ukuzwela kwezinga lokushisa kwe-HPMC kuthinta isikhathi sokubeka kanye nezakhiwo ze-rheological zalezi zinto, ngaleyo ndlela zithinte ukusebenza kwazo ngesikhathi sokwakhiwa.
Izinselele Nezixazululo
Ngenkathi ukuziphatha kwejeli okuncike kukushisa kwe-HPMC kunikeza izinzuzo ezihlukile, kuphinda kube nezinselele kwezinye izinhlelo zokusebenza. Isibonelo, ukuzuza izakhiwo zejeli ezingaguquki kungaba yinselele ekwakhiweni lapho ukuguquka kwezinga lokushisa kuvamile. Abaqulunqi kufanele bacabangele lezi zinselele futhi basebenzise amasu okubhekana nazo.
1. Ukulawula izinga lokushisa ngesikhathi sokulungiselela
Ukuqinisekisa ukusebenza kwejeli okuphindaphindekayo, ukulawula izinga lokushisa okuqinile ngesikhathi sokubunjwa kubalulekile. Lokhu kungase kuhlanganise ukusebenzisa imishini yokuhlanganisa elawulwa izinga lokushisa nokuqapha izinga lokushisa kulo lonke ukwakheka.
2. Ukukhetha i-polymer
Kubalulekile ukukhetha ibanga elifanele le-HPMC elinezici zokushisa zejeli oyifunayo. Amabanga ahlukene e-HPMC ayatholakala ngezisindo zamangqamuzana ahlukene kanye namazinga ahlukile, okuvumela abaklami ukuthi bakhethe i-polymer elungele kangcono uhlelo lwabo lokusebenza oluthile.
3. Ukwenza ngcono okwengeziwe
Ukuba khona kwezithasiselo kuthinta izinga lokushisa le-gelling le-HPMC. Umenzi wefomula angase adinge ukuthuthukisa uhlobo nokugxila kwezithasiselo ukuze azuze izici zejeli ezifunekayo. Lokhu kudinga indlela ehlelekile kanye nokuqonda okuphelele kokusebenzelana phakathi kwe-HPMC nezithasiselo.
IHydroxypropylmethylcellulose (HPMC) iyi-polymer esebenza ngezinto eziningi enezakhiwo zejeli ezihlukile ezithintwa izinga lokushisa. I-gelation encike kuzinga lokushisa ye-HPMC inemithelela ebalulekile ezimbonini ezimbalwa ezihlanganisa ezemithi, ezokwakha, nezimonyo. Ukuqonda izici ezithonya izinga lokushisa kwe-gelation, njengokugxiliswa kwe-polymer, isisindo samangqamuzana, nokuba khona kwezithasiselo, kubalulekile kubadidiyeli abafuna ukuthuthukisa ukusebenza kwejeli kwezinhlelo zokusebenza ezithile.
Njengoba ubuchwepheshe buthuthuka kanye nocwaningo lwesayensi ye-polymer luqhubeka, ukuqonda okwengeziwe kokuziphatha okuncika kwezinga lokushisa kwe-HPMC kungase kuholele ekwakhiweni kokwakheka okusha kanye nezinhlelo zokusebenza. Ikhono lokulungisa kahle izakhiwo zejeli livula amathuba amasha okuklama izinto ezinezici ezenziwe ngokwezifiso, okusiza intuthuko ekulethweni kwezidakamizwa, i-biomaterials neminye imikhakha.
Isikhathi sokuthumela: Jan-11-2024