IHydroxypropyl methylcellulose HPMC?

IHydroxypropyl methylcellulose HPMC iyi-cellulose engeyona i-ionic exutshwe i-ether phakathi kwama-ether ahlukahlukene axutshwe ne-ionic methylcarboxymethylcellulose. Ayisabeli ngezinsimbi ezisindayo. Umehluko kokuqukethwe kwe-hydroxypropyl methylcellulose, hydroxypropyl methylcellulose, kanye ne-hydroxypropyl content ratio kanye ne-viscosity yofuzo olungenayo umoya-mpilo kunezinhlobo ezihluke ngokuphelele ngokusebenza. Isibonelo, izinhlobo ezinokuqukethwe okuphezulu kwe-methoxyl nokuqukethwe kwe-hydroxypropyl ephansi zinokusebenza okuhlukile. Eduze kwe-methylcellulose kanye nezinhlobo eziphansi zokuqukethwe kwe-methoxy. Uma kuqhathaniswa nezinhlobonhlobo ezinokuqukethwe okuphezulu kwe-hydroxypropyl, ukusebenza kwayo kusondele kulokho kwe-hydroxypropyl methylcellulose ekhiqizwayo. Kodwa-ke, nakuba uhlobo ngalunye luqukethe inani elincane kuphela leqembu le-hydroxypropyl noma inani elincane leqembu le-methoxy, kunomehluko omkhulu ekuncibilikeni kwezinyibilikisi eziphilayo noma izinga lokushisa le-flocculation ezixazululweni ezinamanzi.

1. Ukuncibilika kwe-hydroxypropyl methylcellulose

Ukunyibilika kwe-hydroxypropyl methylcellulose emanzini I-Hydroxypropyl methylcellulose empeleni iyi-propylene oxide (i-methylhydroxypropyl ring) eguquliwe i-methylcellulose, ngakho-ke isenezinto ezifanayo njenge-methylcellulose Inezici ezifanayo zokuncibilika emanzini abandayo kodwa engancibiliki emanzini ashisayo. Kodwa-ke, izinga lokushisa le-gelling le-hydroxypropyl eguquliwe emanzini ashisayo liphakeme kakhulu kunalelo le-methylcellulose. Isibonelo, isixazululo samanzi se-hydroxypropyl methylcellulose esingu-2% esinokuqukethwe kweqembu le-methoxy DS=0.73 kanye nokuqukethwe kweqembu le-hydroxypropyl MS=0.46 kune-viscosity engu-500mpa ku-20°C. Izinga lokushisa lejeli lomkhiqizo we-S lisondele ku-100°C, kanti ele-methylcellulose ezingeni lokushisa elifanayo licishe libe ngu-55°C. Ngokuqondene nokuncibilika kwayo emanzini, nayo ithuthukiswe kakhulu. Isibonelo, ngemva kokuchotshozwa kwe-hydroxypropyl methylcellulose (umumo wezinhlayiyana ungu-0.2~0.5mm, i-viscosity yamanzi angu-4% ku-20°C ngu-2pA·S, ingasetshenziswa ekamelweni lokushisa ngaphandle kokupholisa. Incibilika kalula emanzini).

(2) Ukunyibilika kwe-hydroxypropyl methylcellulose kuzincibilikisi zemvelo Ukuncibilika kwe-hydroxypropyl methylcellulose kuzinyibilikisi zemvelo nakho kungcono kunaleyo ye-methylcellulose. I-Methylcellulose idinga i-methoxy substitution degree engu-2.1 Le mikhiqizo engenhla iqukethe i-high-viscosity hydroxypropyl methylcellulose ne-hydroxypropyl MS=1.5~1.8 kanye ne-methoxy DS=0.2~1.0, enezinga eliphelele lokushintsha elingaphezu kuka-1.8, futhi lincibilika kalula ku-anhydrous izixazululo ze-ethanol. Thermoplastic futhi amanzi-encibilikayo. Iphinde inyibilike kuma-hydrocarbons ane-chlorine njenge-methylene chloride ne-chloroform, nezinyibilikisi eziphilayo njenge-acetone, i-isopropyl alcohol kanye ne-diacetone alcohol. Ukuncibilika kwayo ezincibilikisini eziphilayo kungcono kunokuncibilika emanzini.

2. Izinto ezithinta i-viscosity ye-hydroxypropyl methylcellulose

I-Hydroxypropyl methylcellulose viscosity factor Isilinganiso se-viscosity esijwayelekile se-hydroxypropyl methylcellulose siyefana namanye ama-cellulose ether, futhi silinganiswa ku-20°C ngesisombululo esinamanzi esingu-2% njengesijwayelekile. I-viscosity yomkhiqizo ofanayo iyanda njengoba ukugxila kukhula. Ngemikhiqizo ene-concentration efanayo kanye nezisindo ezihlukene zamangqamuzana, umkhiqizo onesisindo esikhulu samangqamuzana une-viscosity ephakeme. Ubuhlobo bayo nezinga lokushisa bufana nobe-methylcellulose. Lapho izinga lokushisa likhuphuka, i-viscosity iqala ukwehla, kodwa lapho ifinyelela izinga lokushisa elithile, i-viscosity iphakama ngokuzumayo futhi i-gelation ivela. Imikhiqizo ye-viscosity ephansi inezinga lokushisa eliphakeme le-gelling kunemikhiqizo ephezulu ye-viscosity. Iphuzu lejeli alihlobene kuphela ne-viscosity ye-ether, kodwa futhi lihlobene nesilinganiso sokubunjwa kwamaqembu e-methoxy ne-hydroxypropyl ku-ether kanye nenani eliphelele lokushintsha. Kumele kuqashelwe ukuthi i-hydroxypropyl methylcellulose nayo iyi-pseudoplastic; izixazululo zayo zizinzile uma zigcinwe ekamelweni lokushisa futhi azibonisi noma yikuphi ukwehla kwe-viscosity, ngaphandle kokuwohloka okungenzeka kwe-enzymatic.

3. I-Hydroxypropyl methylcellulose iyi-asidi ne-alkali ukumelana

IHydroxypropyl methylcellulose iyi-asidi ne-alkali ukumelana. IHydroxypropyl methyl cellulose iyi-asidi ne-alkali ukumelana. Ngokuvamile izinzile futhi ngeke ithintwe ivelu ye-pH ebangeni le-PH2~12. Ingakwazi ukumelana nenani elithile lama-asidi abuthakathaka, njenge-formic acid, i-acetic acid, nolamula. I-Acid, i-succinic acid, i-phosphoric acid kodwa i-asidi egxilile inomphumela wokunciphisa i-viscosity. I-alkali efana ne-caustic soda, i-caustic potassium, namanzi e-lime ayinamthelela kuwo, kodwa umphumela wokwandisa kancane i-viscosity yesisombululo uzokwehla kancane kancane kamuva.

4. IHydroxypropyl methylcellulose ingaxutshwa

Isixazululo se-Hydroxypropyl methylcellulose singaxutshwa nezinhlanganisela ze-polymer ezincibilika emanzini ukuze kwakhiwe isixazululo esifanayo nesisobala esine-viscosity ephezulu. Lezi zinhlanganisela ze-polymer zihlanganisa i-polyethylene glycol, i-polyvinyl acetate, i-polysiloxane, i-polymethyl vinyl siloxane, i-hydroxyethyl cellulose ne-methyl cellulose. Izinhlanganisela ze-polymer zemvelo ezifana ne-acacia gum, intshungama kabhontshisi wezinkumbi, inhlaka yesikhonyane, njll. nazo zinokuhlangana okuhle. ikhambi layo. IHydroxypropyl methylcellulose ingabuye ixutshwe ne-stearic acid noma i-mannitol palmitate noma i-sorbitol, futhi ingaxutshwa ne-glycerin, i-sorbitol ne-mannitol. Lezi zinhlanganisela zingasetshenziswa njenge-ejenti ye-hydroxypropyl methylcellulose plasticizers.

5. IHydroxypropyl methylcellulose ayincibiliki emanzini

I-Hydroxypropyl methylcellulose ayincibiliki kuma-cellulose ethers ancibilikayo emanzini futhi ingaxhunyaniswa phezulu nama-aldehydes, okubangele ukuthi lawa ma-ether ancibilika emanzini ageleze esixazululweni futhi angancibiliki emanzini. Futhi wenze i-hydroxypropyl methylcellulose ingancibiliki kuma-aldehydes, i-formaldehyde, i-glyoxal, i-succinic acid, i-dialdehyde, njll. Uma usebenzisa i-formaldehyde, ukunakwa okukhethekile kufanele kukhokhwe ukubaluleka kwe-pH yesisombululo. Phakathi kwazo, i-glyoxal isabela ngokushesha, ngakho-ke isetshenziswa embonini I-Glyoxal ivame ukusetshenziswa njenge-ejenti yokuxhumanisa ekukhiqizeni. -I-ejenti exhumanisayo. Umthamo walolu hlobo lwe-ejenti yokuxhumanisa esixazululweni ngu-0.2% kuya ku-10% wesisindo se-ether, futhi okungcono kakhulu ngu-7% kuya ku-10%. Uma i-glyoxal isetshenziswa, i-3.3% kuya ku-6% ifaneleka kakhulu. Izinga lokushisa elijwayelekile lokwelashwa ngu-0~30℃ futhi isikhathi ngu-1~120min. Ukusabela kokuxhumanisa kufanele kwenziwe ngaphansi kwezimo ze-acidic. Ngokuvamile, i-asidi eqinile ye-inorganic noma i-organic carboxylic acid yengezwa esixazululo ukulungisa i-pH yesixazululo ibe ngu-2 kuye ku-6, okungcono kakhulu phakathi kuka-4 no-6, bese kwengezwa ama-aldehydes ukwenza ukusabela okuxhumanisa. Ama-acids asetshenziswayo ahlanganisa i-hydrochloric acid, i-sulfuric acid, i-phosphoric acid, i-formic acid, i-acetic acid, i-glycolic acid, i-succinic acid noma i-citric acid, phakathi kwayo i-formic acid noma i-acetic acid ihamba phambili, futhi i-formic acid ihamba phambili. Ama-Acid nama-aldehyde nawo angengezwa kanyekanye ukuze anqamule isixazululo phakathi kwebanga le-pH elifunekayo. Lokhu kusabela kuvame ukusetshenziswa esinyathelweni sokugcina senqubo yokulungiselela i-cellulose ether ukwenza i-cellulose ether ingancibiliki futhi kube lula ukuwasha nokuhlanza ngamanzi angu-20~25°C. Uma usebenzisa umkhiqizo, ungakwazi ukwengeza izinto ezine-alkali kusixazululo somkhiqizo ukuze ulungise i-pH yesisombululo ukuze ibe yi-alkaline ukuze umkhiqizo ukwazi ukuncibilika ngokushesha esixazululweni. Le ndlela ingasetshenziswa futhi lapho ifilimu ilungiswa kusetshenziswa isixazululo se-cellulose ether bese ifilimu icutshungulwa ibe yifilimu engancibiliki.

6. I-Hydroxypropyl methylcellulose anti-enzyme

Okuphuma ku-cellulose kwe-hydroxypropyl methylcellulose ngokwethiyori amelana nama-enzyme. Isibonelo, iqembu ngalinye le-anhydroglucose liboshwe ngokuqinile neqembu elingena esikhundleni futhi alikwazi ukuguguleka nokungenwa yizifo. Kodwa-ke, eqinisweni, inani lokushintshanisa lomkhiqizo oqediwe lidlula i-1. Lingase futhi lonakaliswe ngama-enzyme, okubonisa ukuthi izinga lokushintshwa kweqembu ngalinye ochungechungeni lwe-cellulose alilingani, futhi ama-microorganisms angakwazi ukuqothula amaqembu aseduze e-anhydroglucose angashintshiwe ukuze akhe. ushukela, ongamuncwa ama-microorganisms njengokudla. Ngakho-ke, uma izinga lokushintshwa kwe-ether ye-cellulose likhuphuka, ukumelana kwama-cellulose ethers ekuhlaselweni kwe-enzymatic kuzokhula. Kubikwa ukuthi ngaphansi kwezimo ezilawulwayo, i-hydroxypropyl methylcellulose (DS=1.9), i-methylcellulose (DS=1.83), i-methylcellulose (DS=1.66), i-hydroxyethylcellulose (1.7%) Ama-viscosity asele angu-13.2%, 7.3%, 3.8% no-1.8% ngokulandelana. IHydroxypropyl methylcellulose inamakhono aqinile e-anti-enzyme. Kungabonakala ukuthi i-hydroxypropyl methylcellulose inokumelana okuhle kakhulu kwe-enzyme, ehambisana nokuhlakazeka kwayo okuhle, ukuqina kanye nezakhiwo zefilimu, ingasetshenziswa ekugqokeni kwe-emulsion, njll, futhi ngokuvamile ayidingi ukufakwa kwezivimbelakuvunda. Kodwa-ke, ukuze kuvinjwe isixazululo ekugcinweni kwesikhathi eside noma ukungcola kwangaphandle okungenzeka, kungafakwa ama-preservatives, futhi ukukhethwa kwama-preservatives kunganqunywa ngokusekelwe ezidingweni zokugcina zesisombululo. I-Phenylmercuric acetate kanye ne-manganese fluorosilicate yizilondolozi ezisebenzayo, kodwa zinobuthi futhi kufanele ziphathwe ngokucophelela. Ngokuvamile, i-1 kuya ku-5 mg ye-phenylmercuric acetate ingangezwa ilitha ngalinye lesixazululo.

7. Ukusebenza kwe-hydroxypropyl methylcellulose membrane

I-Hydroxypropyl methylcellulose ukwakha ifilimu I-Hydroxypropyl methylcellulose inezici ezinhle kakhulu zokwenza ifilimu. Lapho isixazululo saso esinamanzi noma isixazululo se-organic solvent simbozwe epuleti lengilazi, iba ifilimu engenambala, esobala futhi eqinile ngemva kokumiswa. . Inokumelana okuhle nomswakama futhi ihlala iqinile emazingeni okushisa aphezulu. Uma i-plasticizers ye-hygroscopic yengezwa, ukunwetshwa nokuguquguquka kungathuthukiswa, futhi ukuguquguquka kungathuthukiswa. Ama-Plasticizer afana ne-glycerol ne-sorbitol yiwona afaneleka kakhulu. Isixazululo esijwayelekile singu-2% ~ 3%, kanti umthamo we-plasticizer ngu-10% ~ 20% we-cellulose ether. Uma okuqukethwe kwe-plasticizer kuyadingeka ukuba kube phezulu, i-colloid syneresis izokwenzeka ngaphansi komswakama ophezulu. Amandla aqinile wefilimu ene-plasticizer eyengeziwe makhulu kakhulu kunefilimu ngaphandle kwe-plasticizer, futhi iyanda ngenani le-plasticizer eyengeziwe. I-hygroscopicity yefilimu nayo iyanda ngenani le-plasticizer.