IHydroxypropyl Methyl Cellulose HPMC

IHydroxypropyl methylcellulose(i-HPMC) iwumphumela we-cellulose osetshenziswa kakhulu ezimbonini ezahlukahlukene, kufaka phakathi ezemithi, ukudla, ezokwakha, nokunakekela komuntu siqu. Yenziwa ngokushintsha i-cellulose amakhemikhali ngokusebenzisa i-etherification, okubandakanya ukwethulwa kwamaqembu e-hydroxypropyl kanye ne-methyl ku-molecule ye-cellulose.

I-HPMC iyimpushana engenaphunga emhlophe kuya kokumhlophe encibilika emanzini futhi yakhe isixazululo esicacile, esibonakalayo. Inezinhlobonhlobo zezakhiwo ezenza kube usizo ezinhlelweni ezahlukahlukene. Isibonelo, iyi-thickener, stabilizer, ne-emulsifier emikhiqizweni yokudla. Ekwakhiweni, isetshenziswa njenge-ejenti yokugcina amanzi kusimende nodaka ukuze kuthuthukiswe ukusebenza kahle nokuvimbela ukuqhekeka. Emikhiqizweni yokunakekelwa komuntu siqu, isetshenziswa njenge-thickener kanye ne-emulsifier kuma-lotions, okhilimu, neminye imikhiqizo.

Kwezemithi, i-HPMC isetshenziswa njenge-binder, disintegrant, kanye ne-ejenti ekhishwayo elawulwayo kumaphilisi namaphilisi. Ibuye isetshenziswe njenge-ejenti yokumisa ekwakhekeni kwe-liquid nanjenge-lubricant kuma-ointments nama-creams. I-HPMC iyisamukeli esamukelwa kabanzi embonini yezemithi ngenxa yokuhambisana kwayo nezinto eziphilayo, ukuphepha, kanye nobuthi obuphansi.

I-HPMC inamabanga amaningana anamazinga ahlukene e-viscosity, aqokwa ngekhodi yezinombolo. Inani eliphakeme kakhulu, i-viscosity ephezulu. Amabanga e-HPMC asukela ku-viscosity ephansi (5 cps) ukuya ku-viscosity ephezulu (100,000 cps). I-viscosity ye-HPMC iyisici esibalulekile ekunqumeni izakhiwo zayo kanye nezicelo.

Ukusetshenziswa kwe-HPMC kwezemithi kukhule eminyakeni yamuva nje ngenxa yezakhiwo zayo eziguquguqukayo kanye nesidingo esikhulayo sezinhlelo ezintsha zokulethwa kwezidakamizwa. Ama-hydrogel asuselwa ku-HPMC asetshenziswe ezinhlelweni zokulethwa kwezidakamizwa ngenxa yokuhambisana kwawo ne-biocompatibility, ukukhululwa okulawulwayo, kanye nezakhiwo zokunamathisela i-mucoadhesive. Amathebulethi asuselwa ku-HPMC nawo athuthukisiwe anezakhiwo ezishintshiwe ezivumela ukulethwa kwezidakamizwa okuhlosiwe kanye nokuthobelana kwesiguli okuthuthukisiwe.

Nokho, i-HPMC ayikho ngaphandle kwemikhawulo yayo. Inokuncibilika okungalungile kuzincibilikisi zemvelo futhi izwela izinguquko ze-pH. Ngaphezu kwalokho, inebanga lokushisa elilinganiselwe futhi ingalahlekelwa yi-viscosity yayo emazingeni okushisa aphezulu. Le mikhawulo iholele ekuthuthukisweni kokunye okuphuma ku-cellulose, okufana ne-hydroxyethyl cellulose (HEC) ne-carboxymethyl cellulose (CMC), ezithuthukise izakhiwo kanye nezigaba zokusetshenziswa ezibanzi.

Sengiphetha, i-HPMC iwukuphuma okuhlukahlukene kwe-cellulose esetshenziswa kakhulu ezimbonini ezahlukahlukene, ikakhulukazi kwezokwelapha. Izakhiwo zayo ezihlukile, okuhlanganisa nokuvumelana kwayo kwezinto eziphilayo, ukuphepha, kanye nobuthi obuphansi, kuyenza ibe isamukeli esidumile ekwakhiweni kwezidakamizwa. Amasistimu okulethwa kwezidakamizwa asekelwe ku-HPMC abonise isithembiso ekuthuthukiseni ukusebenza kwezidakamizwa nokuthobela isiguli. Kodwa-ke, ukulinganiselwa kwayo ekuncibilikeni nasekuzweleni kwe-pH kuye kwaholela ekuthuthukisweni kokunye okuphuma ku-cellulose ngezakhiwo ezithuthukisiwe.