Ukwakha Izithasiselo I-Hydroxypropyl Methylcellulose Amanzi Abandayo Ancibilikisiwe

IHydroxypropyl methylcellulose (HPMC) iyi-semi-synthetic, i-polymer encibilika emanzini eyenziwe nge-cellulose. Isetshenziswa kakhulu ezimbonini ezahlukahlukene ezifana nemithi, ukudla, izimonyo, nezokwakha ngenxa yezakhiwo zayo ezinhle kakhulu, okuhlanganisa ikhono elihle lokwenza ifilimu, ukuqina, ukubopha, nokugcinwa kwamanzi.

Esinye sezici ezibaluleke kakhulu ze-HPMC yikhono layo lokuncibilika emanzini abandayo, okwenza kube ukukhetha okudumile ezinhlelweni ezidinga inqubo esheshayo nelula yokuqedwa. Kulesi sihloko, sizohlola izici ze-HPMC, izindlela zokuncibilika kwamanzi abandayo, kanye nokusetshenziswa kwayo.

Izakhiwo zeHydroxypropyl Methylcellulose

I-HPMC iyimpushana emhlophe ukuya kokumhlophe engenaphunga, ayinambitheki, futhi engenabuthi. Inokuqina okuhle kwe-thermal futhi ingamelana nohlu olubanzi lwamanani e-pH. I-HPMC iyancibilika emanzini futhi yenza izixazululo ezicacile, ezine-viscous ezine-pH ene-acidic kancane.

Izakhiwo zomzimba nezamakhemikhali ze-HPMC zingashintshwa ngokushintsha izinga layo lokushintshwa (DS) kanye nesisindo sayo samangqamuzana. I-DS ibhekisela enanini lamaqembu e-hydroxyl ku-molecule ye-cellulose athathelwa indawo yiqembu le-methyl noma le-hydroxypropyl. Uma i-DS iphakeme, inani elikhulu lamaqembu ashintshiwe liba likhulu, okuholela esisindweni samangqamuzana esiphansi kanye nokuncibilika kwamanzi okuphezulu.

Isisindo samangqamuzana e-HPMC singaphinda sithinte ukunyibilika kwayo, i-viscosity, kanye nezakhiwo ze-gelation. Isisindo samangqamuzana aphezulu i-HPMC ijwayele ukuba ne-viscosity ephakeme namandla ejeli, kuyilapho i-HPMC enesisindo esiphansi se-molecular ine-solubility engcono emanzini abandayo.

Izindlela Zokuncibilika Kwamanzi Abandayo

Ukuncibilika kwamanzi abandayo kwe-HPMC kubangelwa ikakhulukazi izindlela ezimbili: i-hydrogen bonding kanye ne-steric hindrance.

Ukubopha nge-hydrogen kwenzeka lapho amaqembu e-hydroxyl ku-molecule ye-HPMC ehlangana nama-molecule wamanzi ngamabhondi e-hydrogen. Amaqembu e-hydroxypropyl kanye ne-methyl ku-HPMC angabamba iqhaza ekuxhumaneni kwe-hydrogen nama-molecule wamanzi, athuthukise ukuncibilika.

Ukuvimbela i-steric kubhekisela ekuvinjweni ngokomzimba kwamaketango e-cellulose ngamaqembu amakhulu e-hydroxypropyl namaqembu e-methyl. Isithiyo esibulalayo sivimbela ama-molecule e-HPMC ukuthi akhe ukusebenzisana okuqinile kwama-intermolecular, okuholela ekuncibilikeni kwamanzi okuthuthukisiwe.

Izicelo zeHydroxypropyl Methylcellulose

I-HPMC isetshenziswa kabanzi ezimbonini ezahlukahlukene ngenxa yezakhiwo zayo ezinhle kakhulu. Nazi ezinye zezicelo zayo:

Ezemithi: I-HPMC ivamise ukusetshenziswa njenge-binder, disintegrant, kanye ne-ejenti yokwakha ifilimu kumaphilisi namaphilisi emithi. Ibuye isetshenziswe njenge-thickener kanye ne-stabilizer ekwakhiweni kwe-ophthalmic kanye nekhala.

Ukudla: I-HPMC isetshenziswa njenge-thickener, emulsifier, kanye ne-stabilizer emikhiqizweni ehlukahlukene yokudla efana no-ayisikhilimu, iyogathi, nezingubo zesaladi. Ibuye isetshenziswe njenge-ejenti yokugqoka izithelo nemifino ukuthuthukisa ukubukeka kwazo nempilo yeshalofu.

Izimonyo: I-HPMC isetshenziswa njenge-thickener, emulsifier, kanye ne-ejenti eyenza ifilimu kuzimonyo nemikhiqizo yokunakekelwa komuntu siqu efana namaloshini, ama-shampoos, nama-conditioner.

Ukwakhiwa: I-HPMC isetshenziswa njenge-ejenti yokugcina amanzi, i-thickener, kanye ne-binder ezintweni zikasimende ezifana nodaka nokhonkolo. Ithuthukisa ukusebenza, inciphisa ukuqhekeka, futhi ithuthukise ukunamathela.

Ezinye izinhlelo zokusebenza: I-HPMC iphinde isetshenziswe kwezinye izinhlelo zokusebenza ezahlukahlukene njengokuphrinta kwendwangu, ukwakheka kopende nokuhlanganisa, noyinki.