IHydroxypropyl methylcellulose (HPMC) iyi-polymer eguquguqukayo esetshenziswa kabanzi ezimbonini ezahlukahlukene, kufaka phakathi ezemithi, ezokwakha, ukudla, nezimonyo. Izakhiwo zayo ezihlukile ziyenza ibe wusizo ezinhlelweni ezisukela ezinhlelweni zokulethwa kwezidakamizwa kuye ezintweni zikasimende. I-HPMC isuselwa ku-cellulose, i-polymer yemvelo etholakala ezitshalweni, futhi ukukhiqizwa kwayo kuhilela ukuguqulwa kwamakhemikhali ukuze kuzuzwe izici ezithile.
I-HPMC ihlukaniswe ngamamaki amaningana, ngalinye linezakhiwo ezihlukile kanye nezinhlelo zokusebenza. Lawa mabanga ahluka ngamapharamitha afana nesisindo samangqamuzana, izinga lokushintshwa, kanye ne-viscosity. Ukuqonda lo mehluko kubalulekile ekukhetheni ibanga elifanele lohlelo oluthile. Ake singene sijule emabangeni ahlukahlukene e-HPMC kanye nokusetshenziswa kwawo ngokufanele.
Amabanga e-Viscosity:
I-HPMC itholakala kumabanga ahlukene e-viscosity, ngokuvamile asukela kokuphansi kuya kokubonakala okuphezulu. I-viscosity yezixazululo ze-HPMC incike ezintweni ezifana nesisindo samangqamuzana nezinga lokushintshwa.
Amabanga aphansi e-viscosity avame ukusetshenziswa ezinhlelweni ezidinga ukuqedwa ngokushesha kanye nezinga lokushisa eliphansi le-gelation, njengakwezokwelapha zamaphilisi akhishwa ngokushesha.
Amabanga aphezulu e-viscosity afanele izinhlelo zokusebenza ezifuna ama-gel ashubile noma ukukhululwa isikhathi eside, njengokubunjwa okukhishwa okuqhubekayo emithini yemithi.
I-Degree of Substitution (DS):
I-DS ibhekisela enanini elimaphakathi le-hydroxypropyl kanye ne-methoxy substituent ngeyunithi ngayinye ye-anhydroglucose kuketango le-cellulose. Kuthinta ukunyibilika, ukugezwa, kanye nezakhiwo zefilimu ze-HPMC.
Amabanga anamanani aphezulu e-DS ngokuvamile abonisa ukuncibilika kwamanzi okuthuthukisiwe nokwakheka kwefilimu, okuwenza afanelekele izinhlelo zokusebenza ezifana nokumbozwa kwefilimu emikhiqizweni yemithi noma njenge-ejenti ejiyayo emikhiqizweni yokudla.
Amabanga aphansi e-DS angase anikeze ukuqina okungcono kokushisa kanye nezakhiwo zokugcina amanzi, okuwenza alungele ukusetshenziswa ezintweni zokwakha ezifana nokunamathiswa kwamathayili noma imikhiqizo esekelwe ku-gypsum.
Usayizi Wezinhlayiyana:
I-HPMC ingakhiqizwa ngosayizi abahlukahlukene bezinhlayiyana, ezithonya izici ezifana nokuhlakazeka, ukugeleza, kanye nokuthungwa ekwakhiweni.
Amabanga kasayizi wezinhlayiyana ezinhle avame ukuthandwa ezinhlelweni ezidinga ukuthungwa okushelelayo nokuhlakazeka okufanayo, njengezimonyo nemikhiqizo yokunakekelwa komuntu siqu.
Amabanga amade kakhulu angase athandwe ezinhlelweni lapho ukugcinwa kwamanzi okuthuthukisiwe noma izici zokulengiswa zidingeka, njengasezigqumeni zengxube eyomile noma izinhlanganisela ezihlanganyelwe.
Ukuhlanzeka Nokuhambisana Nomthetho:
Amabanga e-HPMC ahloselwe izicelo zemithi nokudla kufanele ahlangabezane nezindinganiso eziqinile zokuhlanzeka kanye nezidingo zokulawula.
I-HPMC yezinga lezemithi ihlolwa ngokucophelela ukuze kuqinisekiswe ukuthobelana nezindinganiso ze-pharmacopeial mayelana nobumsulwa, ukungabi khona kokungcola, kanye nokuhambisana nezinye izinto ezisizayo.
I-HPMC yezinga lokudla kufanele ihambisane nemithetho ebekwe iziphathimandla ezifana ne-FDA noma i-EFSA ukuze kuqinisekiswe ukuphepha ukuze kusetshenziswe futhi ihambisane nemithetho yokwengeza ukudla.
Amabanga Akhethekile:
Amanye amabanga e-HPMC enzelwe izinhlelo zokusebenza ezithile, ezifana no-matrics abakhululwa njalo, amasistimu okulethwa kwezidakamizwa alawulwayo, noma ukwakheka kwe-ophthalmic.
Lawa mabanga akhethekile angase acutshungulwe okwengeziwe noma alungiswe ukuze adlulisele imisebenzi ethile, njengokunamathela kwe-mucoadhesion ethuthukisiwe, ukutholakala kwe-bioavailability okuthuthukisiwe, noma amaphrofayili anwetshiwe okukhululwa.
ukukhethwa kwebanga le-HPMC kuncike ezidingweni zohlelo oluhlosiwe, kucatshangelwa izici ezifana ne-viscosity, izinga lokushintsha, usayizi wezinhlayiyana, ubumsulwa, kanye nanoma yimiphi imisebenzi ekhethekile edingekayo. Ukukhetha ibanga elifanele kuqinisekisa ukusebenza okuphelele nezici ezifiselekayo emkhiqizweni wokugcina, noma ngabe ukwakhiwa kwemithi, okokwakha, umkhiqizo wokudla, noma ukwakheka kwezimonyo.
Isikhathi sokuthumela: May-24-2024