Gxila kuma-Cellulose ethers

I-HPMC isebenzisa ekuhlanganiseni amaphilisi

I-HPMC isebenzisa ekuhlanganiseni amaphilisi

amaphilisi enamathela ivame ukusetshenziswa ekulungiseleleni ifomu eliqinile, ngokusho kweamaphilisi enamathela izinto zokwakha zingahlukaniswa zibe powderamaphilisi enamathela, isiqephuamaphilisi enamathela, inhlayiyaamaphilisi enamathela, ithebhulethiamaphilisi enamathela, i-capsuleamaphilisi enamathela; Ngokuvumelana neamaphilisi enamathela izinto zokwakha zihlukaniswe zibe ushukelaamaphilisi enamathela, ifilimu eyingxenyeamaphilisi enamathela, ifilimuamaphilisi enamathela (kusekelwe ezintweni ezihlukahlukene ze-polymer, kuhlanganise ne-entericamaphilisi enamathela), impahla ekhethekileamaphilisi enamathela (njenge-stearic acid, ipharafini, i-polysaccharide); Ngokuvumelana neamaphilisi enamathela ubuchwepheshe, ingahlukaniswa ibe isifuthoamaphilisi enamathela, gcobhoamaphilisi enamathela, ingcindezi eyomileamaphilisi enamathela, i-electrostaticamaphilisi enamathela futhi laminatingamaphilisi enamathela. Phakathi kwabo, fafazaamaphilisi enamathela iyona esetshenziswa kabanzi. Umgomo wawo ukufuthaamaphilisi enamathela uketshezi lube amaconsi enkungu amboze ingaphezulu lezinto (impuphu, izinhlayiya, amaphilisi). Futhi ngokushesha ome ukwakhaamaphilisi enamathela ungqimba: ngokusho kweamaphilisi enamathela inhloso ihlukaniswe emanzini ancibilikayoamaphilisi enamathela, isisu siyancibilikaamaphilisi enamathela, engancibilikiamaphilisi enamathela, ukukhululwa kancaneamaphilisi enamathela, entericamaphilisi enamathela.

 

Indima yeamaphilisi enamathela kuhlanganisa: (1) ukumelana nomswakama, ukukhanya, ukuhlukaniswa komoya ukuze kwandiswe ukuzinza kwezidakamizwa; (2) Gcoba iphunga elibi, unciphise ukuvuselela; (3) Thuthukisa ukubukeka, kulula ukukubona; (4) Lawula indawo yokukhipha izidakamizwa, njengakwijusi yesisu kalula ukuze ikhishwe emathunjini: (5) lawula ukusakazeka kwezidakamizwa, isivinini sokukhululwa: (6) nqoba ukungahambisani, njll.amaphilisi enamathela impahla kufanele ibe nalezi zidingo ezilandelayo: okungeyona ubuthi, akukho inertia yamakhemikhali, azinzile ekushiseni, ekukhanyeni, emanzini, emoyeni, futhi akusabelani nayoamaphilisi enamathela izidakamizwa; (2) ingancibilika ihlakazeke ngokulinganayo endaweni yokuhlakazeka efanelekeamaphilisi enamathela: (3) ingakha ungqimba oluqhubekayo, oluqinile, olubushelelezi, ukumelana nokuqhekeka futhi lunokuhlukaniswa kwamanzi okuhle, ukuhlukaniswa komswakama, ukufiphaza, ukungena komoya;Ukunyibilika kwayo kufanele kuhlangabezane nezidingo - ezilungisiwe, kwesinye isikhathi akumele zithintwe i-PH, kwesinye isikhathi ingancibilika kuphela kububanzi obuthile be-PH. Uhlobo lwezinto ezibonakalayo ezinesici esingenhla ngesikhathi esifanayo alubonakali kakhulu, isizathu sivame ukusebenzisa okuxubileamaphilisi enamathela okuningi, ukuze sifunde komunye nomunye.

 

Ithebhulethiamaphilisi enamathela iyona esetshenziswa kakhulu, ivamise ukusebenzisa ibhodweamaphilisi enamathela nepayipi elingcwatshweamaphilisi enamathela (ukusebenza kahle okuphezuluamaphilisi enamathela umshiniamaphilisi enamathela), lena yokugcina ingcono ifilimuamaphilisi enamathela. Umbhede omanziamaphilisi enamathela ifaneleka kakhulu ezintweni ezinosayizi wezinhlayiyana ezincane njengamapellets kanye nempushana. Uma kuqhathaniswa noshukelaamaphilisi enamathela, ifilimuamaphilisi enamathela inezinzuzo eziningi:( 1)Fundisa isikhathi futhi unciphise izindleko zezinto ezibonakalayo; (2) akukho ukwanda okuphawulekayo kwesisindo: (3) asikho isidingo songqimba olungezansi: (4) ukumelana okuqinile, ukuchoboza nokuqhekeka: (5) kungaphrintwa, futhi akuphazamisi ukubhala nge-chip;(6) Ingavikela ngempumelelo umkhiqizo ethonyeni lokukhanya, umoya namanzi; (7) Awukho umthelela omubi ngesikhathi sokuhlakazeka:( 8) ubuhle bomkhiqizo:( 9) inikeza ithuba lokusebenzisa okungewona amanziamaphilisi enamathela; Izinqubo nezinto zokwakha zingalinganiswa. Manje ukuthuthukiswa komkhiqizo omushaamaphilisi enamathela ukulungiselela ngokuvamile kuthatha ifilimuamaphilisi enamathela, ifilimuamaphilisi enamathela ukwakheka okuyisisekelo kwencwadi kadokotela kubandakanya i-ejenti yokwakha ifilimu (amaphilisi enamathela impahla), i-solvent, i-plasticizer, i-colorant, ingangeza futhi i-ejenti ebangela izimbotshana, isicwecwe esinganyibiliki, njll. Ukwakheka kwefilimuamaphilisi enamathela incwadi kadokotela iyisihluthulelo sempumelelo yeamaphilisi enamathela. Njengamanje, ifilimu encibilikayo emanziniamaphilisi enamathela izinto ezivame ukusetshenziswa zifaka i-hydroxypropyl methyl cellulose (HPMC) ne-hydroxypropyl cellulose (HPC). I-Polyethylene glycol (PEG), i-polyethylene pyrrolidone (PVP), izinto ezincibilikayo ze-enteric kuhlanganise ne-enteric-soluble acrylic resin, i-hydroxypropyl methyl cellulose phthalate (HPMCP). I-Cellulose acetate phthalate ester (CAP). I-Shellac, izinto ezingancibiliki zifaka i-ethyl cellulose (EC), i-zein.

Ngokuhamba kweminyaka, ifilimuamaphilisi enamathela wenze intuthuko emangalisayo. Izinga lendabukoamaphilisi enamathela ukusetshenziswa kwesistimuI-HPMC(i-hydroxypropyl methylcellulose) njenge-polymer eyinhloko, esasetshenziswa kabanzi nanamuhla. HI-PMC-sekelweamaphilisi enamathela amasistimu ahlinzeka ngokusebenza okwanele, kodwa sisekhona isikhala sokuthuthukiswa. I-HPMCamaphilisi enamathela ifilimu ingase inganamatheli kahle kuthebhulethi, ngokuvamile ibe yindeamaphilisi enamathela isikhathi, okuholela ekukhiqizeni kancane. Ukwethulwa okulandelayo kweIsekelwe ku-PVA amaphilisi enamathela amasistimu athuthuke kakhudlwana ukusebenza, okuholele ekubeni ngconoamaphilisi enamathela ukusebenza nokusebenza kahle kokukhiqiza okusheshayo, okusho ukuthi ukukhubazeka mancane amathuba okuthi kwenzeke kumaphilisi.

Njengoba i-viscosity ye-HPMC ikhula, amandla efilimu enziwe i-HPMC ayanda ngokuhambisanayo, futhi ekugcineni ifinyelela kubukhulu amandla efilimu awasakhuli ngokukhula kwe-viscosity ye-HPMC.

Kweamaphilisi enamathela, ukuze kuzuzwe ukusebenza kahle kakhuluamaphilisi enamathela, ngokuvamile ngconoamaphilisi enamathela okuqukethwe okuqinile kwe-liquid, okuzoholela ku-amaphilisi enamathela i-liquid viscosity iphezulu kakhulu, khetha i-viscosity ephansi ye-HPMC ingakwazi ukuxazulula le nkinga ngokuphumelelayo, kodwa kuholele ekutheni amandla efilimu athintekile. Ukulinganisa lezi zinkinga ezingamawele, ukuxuba ama-polymers sekuphenduke ithuluzi elivamile.

Njengoba iI-HPMCOkuqukethwe kwe-E15 kancane kancane kuyanda, i-viscosity yengxube yeI-HPMCe5 futhiI-HPMCI-E15 nayo iyanda kancane kancane.

 

Kushukelaamaphilisi enamathela, siphinde sasuka kwezobuciko saya kwisayensi. Imikhiqizo embozwe ngoshukela ibukeka kahle ngoba inobushelelezi, ecwebezelayo, nesiphetho esimnandi esivala ukunambitha okubabayo. Kodwa izinselelo ezinkulu kushukelaamaphilisi enamathela ilele ekukhiqizeni nasekukhiqizeni kabusha. Ushukelaamaphilisi enamathela kuwumsebenzi onzima kakhulu futhi odla isikhathi okwenziwa ngesandla futhi ingahluka kuye ngeqoqwana kuye ngomuntu owenzaamaphilisi enamathela.


Isikhathi sokuthumela: Dec-23-2023
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