I-HPMC esetshenziswa kumathonsi iso

IHydroxypropyl methylcellulose (HPMC) iyi-polymer esetshenziswa kakhulu embonini yezemithi, ikakhulukazi ekuthuthukisweni kokwakhiwa kwezidakamizwa zamehlo njengamaconsi iso. Amaconsi wamehlo asetshenziselwa ukwelapha izimo ezihlukahlukene ezifana neso elomile, i-glaucoma, kanye nokungezwani komzimba. I-HPMC ingasetshenziswa kumaconsi wamehlo njenge-ejenti ethuthukisa i-viscosity, i-mucoadhesive agent, kanye ne-ejenti evikelayo. Kulesi sihloko, sizohlola ukusetshenziswa kwe-HPMC kumaconsi esweni ngokuningiliziwe.

I-ejenti yokuthuthukisa i-viscosity

Enye yezindima eziyinhloko ze-HPMC kumaconsi wamehlo ukuthuthukisa i-viscosity yabo. I-Viscosity iyipharamitha ebalulekile ekwakhekeni kwe-ophthalmic njengoba isiza ukuqinisekisa ukuthi ukwakheka kuhlala endaweni ye-ocular isikhathi eside ngokwanele ukunikeza izinzuzo zokwelapha. I-viscosity yezixazululo ze-HPMC incike esisindweni samangqamuzana e-polymer kanye nezinga lokushintshwa. Izixazululo ze-HPMC ezinesisindo samangqamuzana aphezulu kanye nezinga lokushintshwa zine-viscosity ephezulu.

I-HPMC iyisithuthukisi se-viscosity esihle kakhulu samaconsi iso njengoba inikeza umphumela wokukhishwa okuqhubekayo ngenxa yezakhiwo zayo zokwenza ijeli. Ijeli eyakhiwe i-HPMC emathonsini asweni yandisa isikhathi sokuthintana phakathi kwesidakamizwa neso, ngaleyo ndlela ithuthukise ukusebenza kahle komuthi. Ngaphezu kwalokho, izixazululo ze-HPMC azifiphazi ukubona, zizenza zibe inketho efanelekile yamaconsi wamehlo.

I-agent ye-mucoadhesive

Enye indima ebalulekile ye-HPMC kumaconsi esweni yizindawo zayo zokunamathisela i-mucoadhesive. I-HPMC inokuhlobana okuphezulu kolwelwesi lwamafinyila, futhi ukusetshenziswa kwayo kumaconsi esweni kungasiza ekweluleni isikhathi sokuhlala sokwakheka endaweni ye-ocular. Lokhu kunenzuzo ikakhulukazi ekwelapheni i-syndrome yeso elomile, lapho ukuvezwa isikhathi eside ekubunjweni kungasiza ekunciphiseni izimpawu zokoma nokungakhululeki.

Izici zokunamathisela i-mucoadhesive ye-HPMC zibangelwa ukusebenzisana kwayo ne-hydrogen bonding nama-mucin glycoprotein. Ama-mucin glycoprotein ayizingxenye eziyinhloko zongqimba lwamafinyila angaphezulu kwe-ocular, olusebenza njengesivikelo sokuzivikela. I-HPMC inganamathela kungqimba lwamafinyila futhi yandise isikhathi sokuthintana sokwakheka endaweni ye-ocular.

Umenzeli ovikelayo

Ngaphezu kwezakhiwo zayo ezithuthukisa i-viscosity kanye ne-mucoadhesive, i-HPMC iphinde isetshenziswe njenge-ejenti yokuvikela emathonsini asweni. I-ocular surface isengozini yokulimala okuvela ezintweni ezingaphandle njengemisebe ye-UV, ukungcola, nomoya owomile. I-HPMC ingenza ifilimu yokuvikela phezu kwendawo ye-ocular engasiza ukuvikela amehlo kulezi zici eziyingozi.

Izici zokuvikela ze-HPMC zibangelwa ukwakheka kongqimba olufana nejeli endaweni ye-ocular. Lesi singqimba sisebenza njengesithiyo esingokomzimba esingasiza ekuvimbeleni ukungena kwama-ejenti ayingozi emehlweni. I-HPMC ingasiza futhi ukuthobisa i-ocular surface futhi inciphise izimpawu zokucasuka kwe-ocular.

Isiphetho

Sengiphetha, i-HPMC iyi-polymer enemisebenzi eminingi ethola ukusetshenziswa okubanzi ekuthuthukisweni kokwakhiwa kwezidakamizwa ze-ophthalmic, ikakhulukazi amaconsi iso. I-HPMC ingathuthukisa i-viscosity yamaconsi wamehlo, angasiza ekwandiseni isikhathi sokuthintana kwawo ne-ocular surface futhi athuthukise ukusebenza kwawo. Izakhiwo ze-HPMC ze-mucoadhesive zingasiza ekwandiseni isikhathi sokuhlala sokwakheka endaweni ye-ocular, ikwenze kube inketho ekahle yokwelapha isifo samehlo esomile. I-HPMC ingaphinda ivikele i-ocular surface ezicini eziyingozi zangaphandle ngokwenza isendlalelo esivikelayo. Ukukhethwa ngokucophelela kwebanga elifanele le-HPMC nokugxilisa ingqondo kungasiza ekuqinisekiseni ukusebenza okuphelele nokuhambisana ekwakhiweni kokwehla kweso.