I-HPMC ku-Pharmaceuticals

I-excipient yezemithi i-hydroxypropyl methyl cellulose (HPMC) iyi-non-ionic cellulose ether excipients, okwamanje iyindlela enkulu kunazo zonke yasekhaya nengaphandle yokusetshenziswa kwezinto ezisizayo zokwelapha - a, njenge-excipient yomuthi ineminyaka engaphezu kwe-30 yomlando. Ayinaphunga, ayinambitheki, ayinabuthi, iyancibilika emanzini abandayo, i-gelation emanzini ashisayo, izinga eliphansi le-viscosity i-HPMC ingasetshenziswa njenge-adhesive, i-ejenti yokunamathela kanye ne-ejenti yokumiswa izinga eliphezulu le-viscosity i-HPMC ingasetshenziswa ukulungisa uhlaka lwezinto ezixubile ukukhululwa okuqhubekayo. amaphilisi, amaphilisi akhishwa ngaso sonke isikhathi, uhlaka lwejeli lwe-hydrophilic esivimba amaphilisi akhishwa njalo, i-ejenti ekhishwayo elawulwayo kanye ne-ejenti yesiteshi se-pore.

Izinto ezisizayo ezenza imithi zibhekisela ezintweni ezisizayo nezisetshenziswa ekukhiqizeni nasekukhishweni kwezidakamizwa. Into, ngaphandle kwesithako esisebenzayo, esihlolelwe ukuphepha futhi ifakwe emkhiqizweni wokwenza imithi. Ama-excipients emithi anemisebenzi ebalulekile yokuxazulula, ukusiza ukuhlakazeka, ukukhululwa okuhamba kancane nokulawulwayo ngaphezu kokwakhiwa, ukugcwalisa abathwali kanye nokuthuthukisa ukuzinza, okungase kuthinte ikhwalithi, ukuphepha nokusebenza kwezidakamizwa.

I-Hydroxypropyl methyl cellulose HPMC ingesinye sezisiza ezinkulu zemithi ekhaya naphesheya, esisetshenziswe njengezihlanganisi zokwelapha iminyaka. Ayinaphunga, ayinambitheki futhi ayinabuthi, iyancibilika emanzini abandayo futhi i-gelatinous emanzini ashisayo. I-HPMC njengezinto ezisizayo ze-hydrophilic polymer zemithi, hhayi nje kuphela ingasetshenziswa njengethebhulethi, i-granule, i-adhesive yephilisi kanye ne-disintegrant, ifilimu yokugqoka impahla, ingasetshenziswa njenge-ejenti ye-colloidal kanye ne-ejenti yokumiswa, ukukhululwa kancane kanye nokulawulwa kokukhululwa kokuvimbela ukukhululwa, okulawulwayo. i-ejenti yokukhulula kanye ne-ejenti yokwenza izimbotshana, kanye nomthwali wokuhlakazeka okuqinile.

I-HPMC njenge-binder ne-ejenti ehlakazayo. I-HPMC njenge-binder inganciphisa i-Angle yokuxhumana yezidakamizwa, ukuze izidakamizwa zibe manzi kalula, futhi amanzi ayo angakhula izikhathi ezingamakhulu, ngakho-ke angakwazi ukuthuthukisa ngokuphawulekayo ukuqedwa noma ukukhululwa kwamaphilisi. I-HPMC ine-viscosity eqinile, ngoba ukuthungwa kwezinto ezingavuthiwe eziqinile noma eziqinile kungathuthukisa i-viscosity yezinhlayiyana zayo, kuthuthukise ukuminyana kwayo. I-viscosity ephansi ye-HPMC ingasetshenziswa njenge-binder ne-ejenti ehlakazayo, i-viscosity ephezulu kuphela njenge-binder, inani liyahlukahluka kuye ngemodeli kanye nezidingo, inani elijwayelekile lingu-2% -5%.

I-HPMC isetshenziswa njengento yokukhululwa elawulwayo yokulungiselela ngomlomo. I-HPMC iwuhlaka lwe-hydrogel olusetshenziswa kakhulu ekulungiseleleni ukukhishwa okuqhubekayo. I-HPMC enezinga eliphansi le-viscosity (5~50mPa•s) ingasetshenziswa njenge-binder, i-ejenti ethuthukisa ukunamathela kanye nosizo lokumiswa, kuyilapho i-HPMC enezinga eliphezulu le-viscosity (4000 ~ 100000mPa•s) ingasetshenziswa ukulungisa uhlaka lwezinto ezixubile ukukhululwa okuqhubekayo. amaphilisi, amaphilisi akhishwa njalo, amaphilisi ejeli e-hydrophilic akhishwa njalo njengesivimbeli. I-HPMC ingancibilika oketshezini lwe-gastric enteric, inezinzuzo zokucindezelwa okuhle, uketshezi oluhle, ikhono eliqinile lokulayisha izidakamizwa kanye nezici zokukhishwa kwezidakamizwa azithintwa i-pH, njll., iyinto ebaluleke kakhulu ye-hydrophilic carrier ohlelweni oluqhubekayo lokulungiselela ukukhululwa, ngokuvamile. isetshenziswa njengohlaka lwejeli ye-hydrophilic kanye nezinto zokunamathela zokulungiswa okuqhubekayo kokukhululwa, futhi isetshenziswe ekulungiseleleni ukuntanta kwesisu, izisetshenziswa ezisizayo zefilimu yezidakamizwa ezikhishwayo.

I-HPMC njenge-ejenti yokwakha ifilimu. I-HPMC inokwakheka okuhle kwefilimu, yakha ifilimu esobala, eqinile, ukukhiqizwa akulula ukunamathela, ikakhulukazi ukumuncwa umswakama kalula, izidakamizwa ezingazinzile, nayo njengengqimba yokuhlukanisa ingathuthukisa kakhulu ukuzinza kwezidakamizwa, ivimbele ukuguquguquka kwefilimu. Uma kuqhathaniswa nokwakheka kwefilimu ye-gelatin, ifilimu ye-HPMC inokufana okuhle nokudluliswa kokukhanya. I-HPMC inezinhlobonhlobo zokucaciswa kwe-viscosity, ukukhethwa okufanele, ikhwalithi yokugqoka, ukubukeka kungcono kunokusetshenziswa kwezinye izinto, ukuhlushwa kwayo okuvame ukusetshenziswa kwe-2% -10%.

I-HPMC njenge-ejenti yokumiswa. Amalungiselelo oketshezi olumisiwe avame ukusetshenziswa kumafomu emithamo yomtholampilo, okungamasistimu okusabalalisa ahlukahlukene emithi eqinile engancibiliki kumidiya yokuhlakazwa koketshezi. Ukuzinza kwesistimu kunquma ikhwalithi yokulungiswa koketshezi olumisiwe. Isixazululo se-HPMC se-colloidal singanciphisa ukushuba kwesixhumi esibonakalayo esiqinile-uketshezi, sinciphise amandla angaphezulu ezinhlayiya eziqinile, ukuze uhlelo lokuhlakazeka oluhlukahlukene luvame ukuzinza, luyi-ejenti ehle kakhulu yokumiswa. I-HPMC isetshenziswa njenge-thiener yamaconsi esweni, enokuqukethwe okungu-0.45% -1.0%.