I-HPMC yomuthi wezilwane

IHydroxypropyl methylcellulose (HPMC) iyipolymer esetshenziswa kakhulu embonini yezemithi, futhi isetshenziswa nasekulungiseni imithi yezilwane. I-HPMC iyi-ether encibilika emanzini, engeyona ionic cellulose etholakala ku-cellulose yemvelo. Kuyi-polymer ephephile, ehambisana ne-biocompatible, futhi ebolayo esetshenziselwa ukuthuthukisa ukuzinza, izakhiwo ze-rheological, kanye ne-bioavailability yemithi yezilwane. Kulesi sihloko, sizoxoxa ngezakhiwo kanye nokusetshenziswa kwe-HPMC emithini yezilwane.

Izakhiwo ze-HPMC

I-HPMC i-semi-synthetic polymer etholakala ku-cellulose. Inenani lezinto eziyenza ifanelekele ukusetshenziswa emithini yezilwane. Lezi zakhiwo zihlanganisa:

Ukunyibilika kwamanzi: I-HPMC incibilika kakhulu emanzini, okusho ukuthi ingancibilika kalula emanzini nakwezinye izixazululo ezinamanzi. Lokhu kwenza kube lula ukufaka emithini yezilwane.

Ukuziphatha kwe-Pseudo-plastic: I-HPMC ibonisa ukuziphatha kwepulasitiki mbumbulu, okusho ukuthi iyi-thixotropic kanye ne-shear-thinning. Le ndawo ivumela ukuthi inciphise i-viscosity yokumiswa lapho ingaphansi kwengcindezi ye-shear, okwenza kube lula ukuphatha imithi yezilwane.

Ikhono lokwenza ifilimu: I-HPMC inekhono elihle lokwenza ifilimu, okusho ukuthi ingakha ungqimba oluvikelayo phezu kwezinhlayiya zomuthi wezilwane, okusiza ukuzivikela ekonakalisweni nasekuhlanganisweni.

Izakhiwo ze-Mucoadhesive: I-HPMC inezinto zokunamathisela i-mucoadhesive, okusho ukuthi ingakwazi ukunamathela ebusweni be-mucosal emzimbeni. Lesi sakhiwo siwusizo ikakhulukazi ezinhlelweni zokulethwa kwezidakamizwa ngomlomo namakhala, njengoba zivumela isikhathi eside sokuthintana ne-mucosal surface kanye nokumuncwa okuthuthukisiwe kwezidakamizwa.

Ukusetshenziswa kwe-HPMC ku-Veterinary Medicine

I-HPMC isetshenziswa ezinhlobonhlobo zemithi yezilwane. Okunye okuvamile ukusetshenziswa kwe-HPMC emithini yezilwane kufaka:

Ukuzinzisa: I-HPMC isetshenziselwa ukuthuthukisa ukuzinza kwemithi yezilwane. Kungasiza ekuvimbeleni ukuhlangana kwezinhlayiyana, ukugeleza, kanye ne-sedimentation, okungathuthukisa impilo yeshalofu yomuthi.

Ukuguqulwa kwe-Rheological: I-HPMC ingasetshenziswa ukuguqula izakhiwo ze-rheological zemithi yezilwane. Kungasiza ukunciphisa i-viscosity yomuthi, okungenza kube lula ukuphatha.

Ukukhululwa okulawulwayo: I-HPMC ingasetshenziswa ukuzuza ukukhululwa okulawulwayo kwezidakamizwa emithini yezilwane. Ikhono lokwenza ifilimu le-HPMC liyivumela ukuthi yakhe ungqimba oluvikelayo ebusweni bezinhlayiya zomuthi, okungabambezela ukuphuma komuthi emzimbeni.

Ukuthuthukiswa kwe-Bioavailability: I-HPMC ingathuthukisa ukutholakala kwezidakamizwa emithini yezilwane. Izakhiwo ze-mucoadhesive ze-HPMC ziyivumela ukuthi ibambelele ku-mucosal ebusweni emzimbeni, okungathuthukisa ukumuncwa kwezidakamizwa kanye nokuba khona kwe-bioavailability.

Ukufihla ukunambitheka: I-HPMC ingasetshenziswa ukuvala ukunambitheka okungemnandi kwezidakamizwa emithini yezilwane. Lokhu kubaluleke kakhulu ekwenziweni komlomo, njengoba kungenza umuthi unambitheke kakhudlwana futhi ube lula ukuwunikeza izilwane.

Ukwakhiwa kwezihloko: I-HPMC iphinde isetshenziswe ekwakhiweni kwezihloko zomuthi wezilwane. Ingasetshenziswa njenge-thickener, stabilizer, ne-emulsifier kumakhilimu, amafutha okugcoba, namajeli. Ukuziphatha kwepulasitiki mbumbulu kwe-HPMC kuyivumela ukuthi ithuthukise ukusabalala nokuvumelana kokwakheka kwesihloko.

Izithako ezijovwayo: I-HPMC ingasetshenziswa emithini yokwelapha yezilwane. Ingasetshenziswa njenge-ejenti yokumisa kanye nesithuthukisi se-viscosity ukuthuthukisa ukuzinza kanye nezakhiwo ze-rheological zomjovo.

Isiphetho

Sengiphetha, i-HPMC iyi-polymer eguquguqukayo esetshenziswa kabanzi embonini yezemithi, kuhlanganisa nemithi yezilwane. Ukuncibilika kwayo emanzini, ukuziphatha kwe-pseudo-plastic, ikhono lokwenza ifilimu, izici zokunamathisela i-mucoadhesive, nekhono lokufihla ukunambitheka kuyenza ibe isithako esibalulekile ekwakhiweni kwemithi yezilwane. I-HPMC ingathuthukisa ukuzinza, izici ze-rheological, i-bioavailability, kanye nokunambitheka kwemithi yezilwane, iyenze ibe lula ukuyiphatha futhi iphumelele kakhulu ekwelapheni izilwane.