I-HPMC yokumiswa kwebanga lezemithi

IHydroxypropyl methylcellulose (HPMC) iyipolymer esetshenziswa kakhulu embonini yezemithi, ikakhulukazi ngenxa yezakhiwo zayo ekulungiseleleni ukumiswa. I-HPMC iyi-ether encibilika emanzini, engeyona ionic cellulose etholakala ku-cellulose yemvelo. Kuyi-polymer ephephile, ehambisana ne-biocompatible, ne-biodegradable esetshenziselwa ukuthuthukisa ukuzinza, izakhiwo ze-rheological, kanye ne-bioavailability yokumiswa kwemithi. Kulesi sihloko, sizoxoxa ngezakhiwo nokusetshenziswa kwe-HPMC ekumisweni kwebanga lezemithi.

Izakhiwo ze-HPMC

I-HPMC i-semi-synthetic polymer etholakala ku-cellulose. Inenombolo yezakhiwo ezenza ifanelekele ukusetshenziswa ekumisweni kwemithi. Lezi zakhiwo zihlanganisa:

Ukunyibilika kwamanzi: I-HPMC incibilika kakhulu emanzini, okusho ukuthi ingancibilika kalula emanzini nakwezinye izixazululo ezinamanzi. Lokhu kwenza kube lula ukuhlanganisa ukumiswa kwemithi.

Ukuziphatha kwe-Pseudo-plastic: I-HPMC ibonisa ukuziphatha kwepulasitiki mbumbulu, okusho ukuthi iyi-thixotropic kanye ne-shear-thinning. Le ndawo ivumela ukuthi inciphise i-viscosity yokumiswa lapho ingaphansi kwengcindezi ye-shear, okwenza kube lula ukuphatha ukumiswa.

Ikhono lokwenza ifilimu: I-HPMC inekhono elihle lokwenza ifilimu, okusho ukuthi ingakha ungqimba oluvikelayo phezu kwezinhlayiya ezimisiwe, ezisiza ukuzivikela ekonakalisweni nasekuhlanganisweni.

Izakhiwo ze-Mucoadhesive: I-HPMC inezinto zokunamathisela i-mucoadhesive, okusho ukuthi ingakwazi ukunamathela ebusweni be-mucosal emzimbeni. Lesi sakhiwo siwusizo ikakhulukazi ezinhlelweni zokulethwa kwezidakamizwa ngomlomo namakhala, njengoba zivumela isikhathi eside sokuthintana ne-mucosal surface kanye nokumuncwa okuthuthukisiwe kwezidakamizwa.

Ukusetshenziswa kwe-HPMC Ekumisweni Kwebanga Lezemithi

I-HPMC isetshenziswa ezinhlobonhlobo zokumiswa kwebanga lezemithi. Okunye okuvamile ukusetshenziswa kwe-HPMC ekumisweni kwezemithi kufaka:

Ukuzinzisa: I-HPMC isetshenziselwa ukuthuthukisa ukuzinza kokumiswa kwemithi. Kungasiza ukuvimbela ukuhlangana kwezinhlayiyana, ukugobhoza, kanye ne-sedimentation, okungathuthukisa impilo yeshalofu yokumiswa.

Ukuguqulwa kwe-Rheological: I-HPMC ingasetshenziswa ukuguqula izakhiwo ze-rheological zokumiswa kwemithi. Kungasiza ukunciphisa i-viscosity yokumiswa, okungenza kube lula ukuphatha ukumiswa.

Ukukhishwa okulawulwayo: I-HPMC ingasetshenziselwa ukuzuza ukukhululwa okulawulwayo kwezidakamizwa ekumisweni kwemithi. Ikhono lokwenza ifilimu le-HPMC liyivumela ukuthi yakhe ungqimba oluvikelayo ebusweni bezinhlayiya zomuthi, okungabambezela ukuphuma komuthi emzimbeni.

Ukuthuthukiswa kwe-Bioavailability: I-HPMC ingathuthukisa ukutholakala kwezidakamizwa ekumisweni kwemithi. Izakhiwo ze-mucoadhesive ze-HPMC ziyivumela ukuthi ibambelele ku-mucosal ebusweni emzimbeni, okungathuthukisa ukumuncwa kwezidakamizwa kanye nokuba khona kwe-bioavailability.

Ukufihla ukunambitheka: I-HPMC ingasetshenziswa ukufihla ukunambitheka okungajabulisi kwezidakamizwa ekumisweni kwemithi. Ikhono lokwenza ifilimu le-HPMC liyivumela ukuthi yakhe ungqimba oluvikelayo oluzungeze izinhlayiya zomuthi, okungavimbela ukukhululwa komuthi emlonyeni futhi kufihle ukunambitheka kwawo.

Ukuthuthukiswa kokuhambisana: I-HPMC ingathuthukisa ukuhambisana kwezidakamizwa ekumisweni kwemithi. Imvelo encibilikayo emanzini ye-HPMC iyivumela ukuthi incibilike emanzini nakwezinye izixazululo ezinamanzi, ezingathuthukisa ukuhambisana komuthi nezinye izinto ezisizayo ekumisweni.

Isiphetho

I-HPMC iyi-polymer eguquguqukayo esetshenziswa kabanzi embonini yezemithi ngezakhiwo zayo ekulungiseleleni ukumiswa. Ukunyibilika kwayo emanzini, i-pseudo-plastic behavior, ikhono lokwenza ifilimu, izakhiwo ze-mucoadhesive, kanye ne-biocompatibility kuyenza ibe i-polymer ewusizo yokusimamisa ukumiswa kwemithi.