I-HPMC Yezokwelapha

I-HPMCokwemithiisibe yinani elikhulu kunawo wonkeukunakekelwa kwezempilo kanyeizinto ezisizayo zemithi ekhaya naphesheya, ngoba i-HPMC yomuthi inezinzuzo ezinye izihlanganisi ezingenazo.

1. Ukuncibilika kwamanzi

I-HPMC yomuthi iyancibilika emanzini abandayo angaphansi kuka-40 ℃ noma u-70% we-ethanol. Ayincibiliki emanzini ashisayo angaphezu kuka-60 ℃, kodwa iyakwazi ukugaywa.

2. Inertia yamakhemikhali

I-HPMC yomuthi ingeye-ether ye-cellulose engeyona i-ionic, isixazululo sayo asinayo i-ionic charge kanye nosawoti wensimbi noma ama-ionic organic compounds, ngakho-ke ekulungiseleleni inqubo yokukhiqiza, ezinye izinto ezisizayo aziphenduli ngakho.

3. Ukuzinza

Iqinile kukho kokubili i-asidi nesisekelo, futhi ingagcinwa ebangeni le-PH 3 ~ 11 isikhathi eside ngaphandle koshintsho olusobala ku-viscosity. Isixazululo se-aqueous se-HPMC sinokumelana nesikhutha futhi singagcina ukuqina okuhle kwe-viscosity endaweni yokugcina isikhathi eside. Izisetshenziswa zemithi ezisebenzisa i-HPMC emithini, ukuzinza kwekhwalithi yayo kunokusetshenziswa kwezinto ezisizayo zendabuko (njenge-dextrin, isitashi, njll.) kungcono.

4. I-viscosity eguquguqukayo

I-HPMC derivatives ye-viscosity ehlukene ingafaniswa ngokuhambisana nezilinganiso ezahlukene, i-viscosity yayo ingashintsha ngokuhambisana nemithetho ethile, futhi inobudlelwane obuhle bomugqa, ngakho-ke ingakhethwa ngokuvumelana nezidingo zesilinganiso. 2. I-5 inertia ye-metabolic I-HPMC ayimuncwe emzimbeni ayishintshiwe, ayinikezi ukushisa, ngakho-ke i-excipients yokulungiselela imithi ephephile. .

5. Ezokuphepha

I-HPMCokwemithingokuvamile kubhekwa njengento engeyona enobuthi nengacasuli.

IHydroxypropyl methyl cellulose (HPMC) iyinhlanganoi-celluloseI-ether ekhiqizwa ukusabela kwe-chloromethane ne-propylene oxide nge-cellulose eyisisekelo. I-fibre emhlophe noma ecishe ibe mhlophe noma impushana eyimpushana, engenaphunga. Isetshenziswe embonini yezemithi iminyaka engaphezu kwengu-40, futhi iye yamukelwa ku-USP19 edition kanye nohlelo lwesiShayina lwe-Pharmacopoeia 1990. Ifinyelele imiphumela emihle ezintweni zokugqoka ifilimu kanye nezicelo zokunamathela.

Ibanga lezemithiI-HPMCI-hydroxypropyl methyl cellulose inezidingo eziphezulu ezintweni ezingavuthiwe, ubuchwepheshe bokukhiqiza kanye nekhwalithi yomkhiqizo. Eminyakeni yakamuva, ngaphansi kwethonya lezinqubomgomo eziqinile zokuvikela imvelo, amabhizinisi amancane asiza e-East China aze ahoxa emakethe, kanye nebanga lezemithi.I-HPMCi-hydroxypropyl methyl celluloseokwemithiimboni nayo ithintekile, amandla athile okukhiqiza ahoxile, futhi ukugxilisa umthamo kwenziwe ngcono.