IHydroxypropyl Methylcellulose (HPMC) iyi-ether ye-cellulose eguquliwe esetshenziswa kabanzi ekulungiseni imithi, izithasiselo zokudla, izinto zokwakha, izimonyo neminye imikhakha. I-HPMC inokuqina, ukwenza ifilimu, ukunamathela nezinye izakhiwo. Ubudlelwano phakathi kwe-viscosity kanye nokugxila kwesixazululo saso samanzi kubaluleke kakhulu ezinhlelweni ezahlukahlukene.
Izici ze-viscosity zesisombululo samanzi se-HPMC
Izici eziyisisekelo
I-HPMC yenza isixazululo se-viscous esisobala noma esishintshashintshayo ngemva kokuncibilika emanzini. I-viscosity yayo ayithinteki kuphela ngokugxila kwe-HPMC, kodwa futhi nezici ezifana nesisindo samangqamuzana, uhlobo olungena esikhundleni kanye nezinga lokushisa lesisombululo.
Isisindo samangqamuzana: Uma sikhulu isisindo samangqamuzana e-HPMC, siphakamisa i-viscosity yesixazululo. Lokhu kungenxa yokuthi ama-macromolecules akha isakhiwo esixakeke kakhudlwana esixazululweni, okwandisa ukungqubuzana phakathi kwama-molecule.
Uhlobo lwe-substituent: Isilinganiso se-methoxy ne-hydroxypropoxy substituents sithinta ukunyibilika kanye ne-viscosity ye-HPMC. Ngokuvamile, lapho okuqukethwe kwe-methoxy kuphakeme, ukuncibilika kwe-HPMC kuba ngcono futhi i-viscosity yesisombululo nayo iphakeme.
Ubudlelwano phakathi kokuhlushwa kanye ne-viscosity
Isigaba sesixazululo se-Dilute:
Uma ukuhlushwa kwe-HPMC kuphansi, ukusebenzisana phakathi kwama-molecule kubuthakathaka futhi isixazululo sibonisa izakhiwo ze-Newtonian fluid, okungukuthi, i-viscosity ngokuyisisekelo izimele ngaphandle kwesilinganiso sokugunda.
Kulesi sigaba, i-viscosity yesisombululo iyanda ngokuhambisana nokugxila okwandayo. Lobu budlelwano bomugqa bungavezwa nge-viscosity equation elula:
| Ukugxila (%) | I-Viscosity (mPa·s) |
| 0.5 | 100 |
| 1.0 | 300 |
| 2.0 | 1000 |
| 5.0 | 5000 |
| 10.0 | 20000 |
Kungabonakala kudatha ukuthi i-viscosity yesisombululo se-aqueous se-HPMC ikhuphuka kakhulu ngokunyuka kokugxila. Lokhu kukhula kuzovela kugrafu njengejika elikhuphukayo, ikakhulukazi ezindaweni zokugxila okuphezulu.
Izici ezinomthelela
Umthelela wezinga lokushisa
Izinga lokushisa linomthelela omkhulu ku-viscosity yesisombululo se-HPMC. Ngokuvamile, ukwanda kwezinga lokushisa kunciphisa i-viscosity yesisombululo. Lokhu kungenxa yokuthi izinga lokushisa elikhulayo lidala ukunyakaza kwamangqamuzana futhi kwenza buthaka ukusebenzisana phakathi kwamaketanga wamangqamuzana, ngaleyo ndlela kunciphise i-viscosity.
Umthelela wesilinganiso sokugunda
Ukuze uthole izixazululo eziphezulu ze-HPMC, i-viscosity nayo iyathinteka ngezinga le-shear. Emazingeni aphezulu e-shear, ukuqondiswa kwamaketanga amangqamuzana kuba okuhambisanayo futhi ukungqubuzana kwangaphakathi kuyancipha, okuholela ekunciphiseni okubonakalayo kwe-viscosity yesisombululo. Lesi simo sibizwa ngokuthi ukugunda kwe-shear.
Izinhlelo zokusebenza
Emalungiselelweni okwenziwa kwemithi, i-HPMC ivamise ukusetshenziswa embotsheni yethebhulethi, amafomu emithamo yokukhishwa okuqhubekayo, kanye nama-thickeners. Ukuqonda ukuthi i-viscosity yezixazululo zamanzi ze-HPMC ishintsha kanjani ngokugxila kubalulekile ekuklameni ukwakheka kwezidakamizwa ezifanele. Isibonelo, embotsheni yethebhulethi, ukugxiliswa kwe-HPMC okufanelekile kungaqinisekisa ukuthi uketshezi olunamathelayo lune-viscosity eyanele ukumboza ingaphezulu lethebhulethi, kuyilapho lingaphakeme kakhulu ukuthi kube nzima ukuliphatha.
Embonini yokudla, i-HPMC isetshenziswa njenge-thickener ne-stabilizer. Ukuqonda ubudlelwano phakathi kokugxilisa ingqondo kanye ne-viscosity kungasiza ekunqumeni ukugxila okufanele ukuze kuqinisekiswe ukunambitheka nokuthungwa kokudla.
I-viscosity yesisombululo samanzi se-HPMC sinokuhlobana okubalulekile okuhle nokugxila. Ibonisa ukukhuphuka komugqa esigabeni sesixazululo se-dilute kanye nokwanda okubonakalayo kokugxila okuphezulu. Lesi sici se-viscosity sibalulekile ekusetshenzisweni kwezimboni ezihlukahlukene, futhi ukuqonda nokulawula izinguquko ze-viscosity ye-HPMC kubaluleke kakhulu ekuthuthukiseni inqubo kanye nokuthuthukiswa kwekhwalithi yomkhiqizo.
Isikhathi sokuthumela: Jul-08-2024