IHydroxypropyl methylcellulose (HPMC) iyi-polymer esetshenziswa kakhulu emithini yemithi, ikakhulukazi esetshenziselwa ukwandisa isikhathi sokukhululwa kwezidakamizwa. I-HPMC iwumphumela we-semi-synthetic cellulose enokuncibilika kwamanzi kanye nezakhiwo zefilimu. Ngokulungisa isisindo samangqamuzana, ukugxila, i-viscosity nezinye izakhiwo ze-HPMC, izinga lokukhululwa kwezidakamizwa lingalawulwa ngokuphumelelayo, ngaleyo ndlela kuzuzwe ukukhululwa kwezidakamizwa zesikhathi eside nokuqhubekayo.
1. Isakhiwo kanye nendlela yokukhishwa kwezidakamizwa ye-HPMC
I-HPMC yakhiwe ngokushintshwa kwe-hydroxypropyl kanye ne-methoxy yesakhiwo se-cellulose, futhi ukwakheka kwayo kwamakhemikhali kuyinikeza ukuvuvukala okuhle kanye nezakhiwo zefilimu. Lapho ithintana namanzi, i-HPMC imunca ngokushesha amanzi futhi ikhukhumale yakhe ungqimba lwejeli. Ukwakhiwa kwalesi singqimba sejeli kungenye yezindlela ezibalulekile zokulawula ukukhishwa kwezidakamizwa. Ukuba khona kongqimba lwejeli kunciphisa ukungena okuqhubekayo kwamanzi ku-matrix yesidakamizwa, futhi ukusakazeka komuthi kuvinjelwa ungqimba lwejeli, ngaleyo ndlela kubambezeleka izinga lokukhululwa komuthi.
2. Iqhaza le-HPMC kumalungiselelo okukhishwa okuqhubekayo
Kumalungiselelo okukhishwa okuqhubekayo, i-HPMC ivamise ukusetshenziswa njenge-matrix yokukhishwa okulawulwayo. Umuthi uyahlakazwa noma uhlakazwe ku-matrix ye-HPMC, futhi uma uhlangana noketshezi lwamathumbu, i-HPMC iyakhukhumala bese yenza ungqimba lwejeli. Ngokuhamba kwesikhathi, ungqimba lwejeli lukhula kancane kancane, lwakha umgoqo ongokomzimba. Umuthi kufanele ukhishelwe endaweni yangaphandle ngokusebenzisa ukusabalalisa noma ukuguguleka kwe-matrix. Indlela yayo yokwenza ngokuyinhloko ihlanganisa izici ezimbili ezilandelayo:
Indlela yokuvuvukala: Ngemva kokuthi i-HPMC ihlangana namanzi, ungqimba olungaphezulu lumunca amanzi futhi lukhukhumale kwakheka ungqimba lwejeli ye-viscoelastic. Njengoba isikhathi sihamba, ungqimba lwejeli lukhula kancane kancane ngaphakathi, ungqimba lwangaphandle luyavuvukala futhi luyaxebuka, futhi ungqimba lwangaphakathi luyaqhubeka lwakha ungqimba olusha lwejeli. Lokhu kuvuvukala okuqhubekayo kanye nenqubo yokwakheka kwejeli kulawula izinga lokukhululwa komuthi.
Indlela yokusabalalisa: Ukusatshalaliswa kwezidakamizwa ngongqimba lwejeli kungenye indlela ebalulekile yokulawula izinga lokukhululwa. Ungqimba lwejeli lwe-HPMC lusebenza njengesithiyo sokusabalalisa, futhi umuthi udinga ukudlula kulolu ungqimba ukuze ufinyelele ku-in vitro medium. Isisindo samangqamuzana, i-viscosity kanye nokugxila kwe-HPMC ekulungiseleleni kuzothinta izakhiwo zesendlalelo sejeli, ngaleyo ndlela ilawule izinga lokusabalalisa lomuthi.
3. Izinto ezithinta i-HPMC
Kunezici eziningi ezithinta ukusebenza kokukhishwa okulawulwayo kwe-HPMC, okuhlanganisa isisindo samangqamuzana, i-viscosity, umthamo we-HPMC, izakhiwo zomzimba nezamakhemikhali zomuthi, kanye nemvelo yangaphandle (njenge-pH namandla e-ionic).
Isisindo samangqamuzana kanye ne-viscosity ye-HPMC: Uma sikhulu isisindo se-molecule ye-HPMC, siphakamisa i-viscosity yesendlalelo sejeli kanye nezinga lokukhishwa kwezidakamizwa lihamba kancane. I-HPMC ene-viscosity ephezulu ingakha ungqimba lwejeli oluqinile, luvimbele izinga lokusatshalaliswa komuthi, ngaleyo ndlela andise isikhathi sokukhululwa somuthi. Ngakho-ke, ekwakhiweni kwamalungiselelo okukhishwa okuqhubekayo, i-HPMC enezisindo zamangqamuzana ahlukene kanye nama-viscosities ivame ukukhethwa ngokuvumelana nezidingo ukuze kuzuzwe umphumela wokukhululwa olindelekile.
Ukugxila kwe-HPMC: Ukugxila kwe-HPMC nakho kuyisici esibalulekile ekulawuleni izinga lokukhululwa kwezidakamizwa. Lapho i-HPMC iphakeme, ungqimba lwejeli luqina, kukhulu ukumelana nokusabalalisa komuthi ngongqimba lwejeli, kanye nezinga lokukhululwa lihamba kancane. Ngokulungisa umthamo we-HPMC, isikhathi sokukhululwa somuthi singalawulwa ngendlela evumelana nezimo.
Izici ze-physicochemical zezidakamizwa: Ukuncibilika kwamanzi, isisindo samangqamuzana, ukuncibilika, njll. komuthi kuzothinta ukuziphatha kwawo kokukhululwa ku-matrix ye-HPMC. Ngezidakamizwa ezinokuncibilika okuhle kwamanzi, umuthi ungancibilika emanzini ngokushesha futhi usakazeke ngongqimba lwejeli, ngakho izinga lokukhululwa liyashesha. Ezidakamizwa ezinokuncibilika okuncane kwamanzi, ukuncibilika kuncane, umuthi usakazeka kancane kungqimba lwejeli, futhi isikhathi sokukhululwa side.
Umthelela wendawo yangaphandle: Izakhiwo zejeli ze-HPMC zingahluka ezindaweni ezinamavelu e-pH ahlukene namandla e-ionic. I-HPMC ingase ibonise ukuziphatha okuhlukile kokuvuvukala ezindaweni ezine-asidi, ngaleyo ndlela kuthinte izinga lokukhululwa kwezidakamizwa. Ngenxa yoshintsho olukhulu lwe-pH emgudwini wesisu somuntu, ukuziphatha kwe-HPMC matrix amalungiselelo okukhishwa okuqhubekayo ngaphansi kwezimo ze-pH ezihlukene kudinga ukunakwa okukhethekile ukuze kuqinisekiswe ukuthi umuthi ungakhululwa ngokuzinzile nangokuqhubekayo.
4. Ukusetshenziswa kwe-HPMC ezinhlotsheni ezahlukene zamalungiselelo okukhishwa okulawulwayo
I-HPMC isetshenziswa kabanzi kumalungiselelo okukhishwa okuqhubekayo amafomu emithamo ahlukene njengamaphilisi, amaphilisi, nama-granules. Kumaphilisi, i-HPMC njenge-matrix material ingakha ingxube efanayo yesidakamizwa-polymer futhi ikhulule kancane kancane umuthi epheshaneni lamathumbu. Kuma-capsules, i-HPMC iphinde isetshenziswe njenge-membrane ekhishwayo elawulwayo ukuze igqoke izinhlayiya zezidakamizwa, futhi isikhathi sokukhululwa somuthi silawulwa ngokulungisa ukushuba kanye ne-viscosity yesendlalelo sokumboza.
Ukusetshenziswa kumaphilisi: Amaphilisi ayifomu elivame kakhulu lemithamo yomlomo, futhi i-HPMC ivamise ukusetshenziselwa ukuzuza umphumela wokukhululwa okuqhubekayo kwezidakamizwa. I-HPMC ingaxutshwa nezidakamizwa futhi icindezelwe ukwenza isistimu ye-matrix ehlakazeke ngokufanayo. Uma ithebhulethi ingena emgudwini wamathumbu, i-HPMC engaphezulu ivuvukala futhi yakhe ijeli, ebambezela izinga lokuqedwa lomuthi. Ngesikhathi esifanayo, njengoba ungqimba lwejeli luqhubeka lukhula, ukukhululwa kwesidakamizwa sangaphakathi kulawulwa kancane kancane.
Ukusetshenziswa kwama-capsules:
Emalungiselelweni ama-capsule, i-HPMC ivamise ukusetshenziswa njengolwelwesi olulawulwayo lokukhululwa. Ngokulungisa okuqukethwe kwe-HPMC ku-capsule kanye nobukhulu befilimu enamathelayo, izinga lokukhululwa lomuthi lingalawulwa. Ngaphezu kwalokho, i-HPMC inokunyibilika okuhle nokuvumelana kwe-biocompatibility emanzini, ngakho-ke inamathemba okusebenza abanzi ezinhlelweni zokukhishwa ezilawulwa yi-capsule.
5. Amathrendi entuthuko yesikhathi esizayo
Ngokuthuthuka kobuchwepheshe bezemithi, ukusetshenziswa kwe-HPMC akugcini nje kuphela ekulungiseleleni ukukhishwa okuqhubekayo, kodwa kungase futhi kuhlanganiswe nezinye izinhlelo ezintsha zokulethwa kwezidakamizwa, njengama-microspheres, ama-nanoparticles, njll., ukuze kuzuzwe ukukhululwa kwezidakamizwa okulawulwa ngokunembe kakhudlwana. Ukwengeza, ngokuqhubeka nokuguqula ukwakheka kwe-HPMC, njengokuhlanganisa namanye ama-polymer, ukuguqulwa kwamakhemikhali, njll., ukusebenza kwayo kumalungiselelo okukhishwa okulawulwayo kungase kuthuthukiswe nakakhulu.
I-HPMC ingandisa ngempumelelo isikhathi sokukhishwa kwezidakamizwa ngendlela yayo yokuvuvukala ukuze yakhe ungqimba lwejeli. Izinto ezifana nesisindo samangqamuzana, i-viscosity, ukugxila kwe-HPMC kanye nezakhiwo ze-physicochemical zomuthi zizothinta umphumela wawo wokukhululwa olawulwayo. Ezisetshenziswa ezingokoqobo, ngokuklama ngokunengqondo izimo zokusebenzisa ze-HPMC, ukukhululwa okuqhubekayo kwezinhlobo ezahlukene zemithi kungafinyelelwa ukuze kuhlangatshezwane nezidingo zomtholampilo. Ngokuzayo, i-HPMC inamathuba abanzi okusebenza emkhakheni wokukhishwa okuqhubekayo kwezidakamizwa, futhi ingase ihlanganiswe nobuchwepheshe obusha ukuze kuthuthukiswe ukuthuthukiswa kwezinhlelo zokulethwa kwezidakamizwa.
Isikhathi sokuthumela: Sep-19-2024