I-HPMC yelula kanjani ukukhululwa kwezidakamizwa?

IHydroxypropyl methylcellulose (HPMC) iyi-polymer yokwenziwa esetshenziswa kakhulu embonini yezemithi ukulawula ukukhishwa kwezidakamizwa. I-polymer engeyona i-ionic, encibilika emanzini eyenza ijeli phambi kwamanzi. I-HPMC isetshenziselwa ukuguqula izinga lokukhululwa kwezidakamizwa kumafomu omthamo, njengamaphilisi, amaphilisi, kanye nokumiswa okwesikhashana. Ibuye isetshenziswe njenge-binder, disintegrant, kanye ne-lubricant ekwenzeni amaphilisi namaphilisi.

I-HPMC isebenza ngokwakha i-matrix yejeli ezungeze izinhlayiya zomuthi. Le matrix yejeli i-semi-permeable, okusho ukuthi ivumela amanzi ukuthi adlule kuyo, kodwa hhayi izinhlayiya zomuthi. Njengoba amanzi edlula ku-matrix yejeli, ancibilikisa kancane izinhlayiya zomuthi, azikhiphele endaweni ezungezile. Le nqubo yaziwa ngokuthi ukukhishwa okulawulwa yi-diffusion.

Izinga lokukhishwa okulawulwa ukusabalalisa lingalawulwa ngokulungisa izakhiwo ze-matrix yejeli ye-HPMC. Isibonelo, i-viscosity ye-matrix yejeli inganyuswa ngokungeza i-HPMC eyengeziwe, ezonciphisa izinga lokukhululwa okulawulwa ngokusakazwa. Usayizi wezinhlayiya zomuthi nawo ungalungiswa, njengoba izinhlayiya ezincane zizosakazeka ngokushesha kunezinhlayiya ezinkulu.

Ngaphezu kokulawula izinga lokukhishwa kwezidakamizwa, i-HPMC futhi inezinye izici ezizuzisayo. Ayinabuthi, ayicunuli, futhi ayiyona i-allergenic, okwenza kuphephe ukusetshenziswa ekwenziweni kwemithi. Futhi akuyona i-hygroscopic, okusho ukuthi ayitholi umswakama ovela emvelweni, okusiza ukugcina ukuzinza kokubunjwa.

I-HPMC iyithuluzi elisebenzayo lokulawula izinga lokukhululwa kwezidakamizwa. Ngokulungisa izici ze-matrix yejeli ye-HPMC, izinga lokukhululwa okulawulwa ukusakazeka kungalungiselelwa ukuhlangabezana nephrofayela yokukhishwa efiswayo. Lokhu kuvumela ukuthuthukiswa kokwakheka okukhulula izidakamizwa ngenani elilawulwayo esikhathini eside.