I-Hydroxypropyl methylcellulose (HPMC) iyi-polymer ebalulekile encibilika emanzini esetshenziswa kabanzi embonini yokwakha, yezemithi, yokudla nezimonyo, ikakhulukazi emkhakheni wokunamathisela. Ukulawulwa kwe-viscosity kwe-HPMC kubalulekile ekusebenzeni komkhiqizo. kubalulekile. Ukuthuthukisa i-viscosity ye-HPMC kuma-adhesives kungafinyelelwa ngokulungisa izakhiwo zayo ezingokwenyama namakhemikhali, kanye nokuthuthukisa ukubunjwa kanye nemvelo yohlelo lokusebenza.
1. Lungisa isisindo samangqamuzana e-HPMC
I-viscosity ye-HPMC incike kakhulu esisindweni sayo samangqamuzana. Ngokuvamile, lapho isisindo samangqamuzana sikhulu, i-viscosity iyanda. Ngokukhetha i-HPMC enesisindo samangqamuzana esifanele, i-viscosity ye-adhesive ingalawulwa ngempumelelo. Ngokuvamile, i-HPMC enesisindo esiphezulu samangqamuzana izokwandisa i-viscosity ye-adhesive, kodwa izophinde ithinte ukugeleza nokusebenza. Ngakho-ke, ibhalansi phakathi kwe-viscosity nokusebenza idinga ukutholakala ezinhlelweni zokusebenza.
2. Lawula izinga lokushintshwa kwe-HPMC
I-HPMC iwumkhiqizo otholwe ku-methylcellulose ngokusabela kwengxenye ye-hydroxypropylation. Izinga layo lokushintsha (okungukuthi, izinga lokushintshwa kwe-hydroxypropyl namaqembu e-methyl) linomthelela omkhulu ku-viscosity. Amadigri aphezulu okushintsha ngokuvamile anciphisa i-viscosity ye-HPMC, kuyilapho amadigri aphansi okushintsha enyusa i-viscosity. Ngakho-ke, ngokulungisa izinga lokushintshwa kwe-HPMC, ukulawula okusebenzayo kwe-viscosity kungafinyelelwa. Ezimeni ezihlukene zohlelo lokusebenza, i-HPMC enamazinga ahlukene okushintsha ingase idingeke ukuze ihlangabezane nezidingo zokusebenza kokunamathelayo.
3. Ukulawulwa kwezinga lokushisa lokuqedwa
I-solubility kanye ne-viscosity ye-HPMC ihlobene eduze nezinga lokushisa. Ngokuvamile, i-HPMC ine-viscosity ephezulu uma incibilika emazingeni okushisa aphansi. Ngokulungiselela izinga lokushisa lokuqedwa kwe-HPMC ngesikhathi sokulungiselela okunamathelayo, i-viscosity yomkhiqizo wokugcina ingalungiswa. Isibonelo, ukuhlakaza i-HPMC emazingeni okushisa aphezulu kungase kubangele i-viscosity yokuqala ephansi, kodwa ukwanda kancane kancane kwe-viscosity njengoba izinga lokushisa lincipha. Ngakho-ke, ngokulawula izinga lokushisa ngesikhathi senqubo yokwakha, ukulungiswa okuguquguqukayo kwe-viscosity kungafinyelelwa.
4. Engeza ukuqina
Kufomula yokunamathisela ye-HPMC, ukwengeza inani elifanele le-thickener kungakhuphula ngempumelelo i-viscosity. Amajiya avamile afaka i-xanthan gum, i-carbomer, i-cellulose derivatives, njll. Lawa ma-thieners asebenza ngokubambisana ne-HPMC ukuze kuthuthukiswe i-viscosity iyonke ye-adhesive. Ngaphezu kwalokho, ama-thickeners angabuye athuthukise ukuzinza kanye nokumelana ne-sag ye-adhesive, inikeze ukusebenza kangcono kuhlelo lokusebenza.
5. Lungisa ukuhlushwa kwesisombululo se-HPMC
Ukugxila kwesixazululo se-HPMC emanzini kunomthelela oqondile ku-viscosity. Ukuphakama kwe-concentration, kukhulu i-viscosity. Ekusetshenzisweni okungokoqobo, i-viscosity ye-adhesive ingashintshwa kalula ngokulawula ukuhlushwa kwesisombululo se-HPMC. Isibonelo, lapho ulungiselela i-adhesive, i-viscosity ingandiswa ngokwandisa kancane kancane inani le-HPMC, noma i-viscosity ingancishiswa ngokuhlanjululwa.
6. Ukwenza ngcono kweresiphi
I-viscosity ye-adhesive ye-HPMC ayincikile kuphela ezicini ze-HPMC ngokwayo, kodwa futhi ihlobene eduze nalo lonke uhlelo lokubunjwa. Ngokuthuthukisa izinhlobo nezilinganiso zezinye izingxenye zefomula, njengezigcwalisi, ama-co-solvents, ama-stabilizers, njll., i-viscosity ingalungiswa ngempumelelo. Isibonelo, ukukhulisa inani lokugcwalisa ngendlela efanele kungakhuphula i-viscosity, kodwa ukugcwaliswa okuningi kungabangela ukunamathela ukuthi kube nokungabi namanzi futhi kwenze kube nzima ukukusebenzisa. Ngakho-ke, ukwakheka kwefomula okunengqondo kuwukhiye wokuthuthukisa i-viscosity ye-HPMC.
7. Ukulungiswa kwevelu ye-pH
I-viscosity ye-HPMC nayo ithintwa yi-pH yesisombululo. Phakathi kwebanga elithile, i-viscosity ye-HPMC iyashintsha ngevelu ye-pH. Ngokuvamile, i-HPMC ibonisa i-viscosity ephakeme ekungathathi hlangothi kuya ezindaweni ezibuthakathaka ze-alkaline, kuyilapho ngaphansi kwezimo ezine-asidi eqinile noma ezine-alkali, i-viscosity ingase yehle kakhulu. Ngakho-ke, ngokulungisa i-pH ye-adhesive, ukulawulwa kwe-viscosity kungafinyelelwa. Isibonelo, kwezinye izinhlelo zokusebenza, i-pH ingaqiniswa ngokwengeza amabhafa ukuze kugcinwe i-viscosity ezinzile.
8. Sebenzisa ama-cross-linking agents
Kwezinye izimo, ukungezwa kwe-cross-linking agents kungakhuphula kakhulu i-viscosity ye-HPMC. Ama-Cross-linking agents angakha izixhumanisi ezibonakalayo noma zamakhemikhali phakathi kwama-molecule e-HPMC futhi athuthukise ukusebenzisana phakathi kwamaketanga wamangqamuzana, ngaleyo ndlela andise i-viscosity. Isibonelo, kuma-adhesives wokwakha, ukuxhumanisa okuphambene kwe-HPMC kungenziwa ngokungeza inani elifanele le-boric acid noma amanye ama-ion ahlukahlukene ukuze kutholwe uhlelo lokunamathela lwe-viscosity ephezulu.
9. Ukulawula izinga lokushisa nokuswakama
Ezisetshenziswa ezingokoqobo, i-viscosity yezinto ezinamathelayo ze-HPMC nayo ithintwa izinga lokushisa elizungezile nomswakama. Ukwenyuka kwezinga lokushisa ngokuvamile kunciphisa i-viscosity ye-HPMC, kuyilapho umswakama owandayo ungabangela ukushintshashintsha kwe-viscosity kokunamathelayo. Ngakho-ke, ukugcina izinga lokushisa elifanele kanye nezimo zomswakama endaweni yokwakha kungasiza ukugcina i-viscosity efanelekile ye-adhesive ye-HPMC.
10. Ukuthuthukisa izimo zokugcina
Izimo zokugcina izinto ezinamathelayo ze-HPMC zinemiphumela yesikhathi eside ku-viscosity. Ukuze kugcinwe ukuzinza kwe-viscosity, ama-adhesives kufanele agcinwe endaweni eyomile, epholile, ukugwema izinga lokushisa eliphezulu kanye nezimo eziphezulu zomswakama. Ngaphezu kwalokho, isikhathi eside sokugcina singaholela ekwehleni kwe-viscosity. Ngakho-ke, ukuhlola njalo i-viscosity ye-adhesive nokwenza izinguquko njengoba kudingekile futhi kuyizinyathelo ezibalulekile zokuqinisekisa ikhwalithi ye-adhesive.
Isikhathi sokuthumela: Sep-03-2024