IHydroxypropyl methylcellulose (HPMC), eyaziwa nangokuthi i-hypromellose, i-polymer esebenza ngezindlela eziningi esetshenziswa ezimbonini ezahlukahlukene ezihlanganisa ezemithi, ukudla, nezokwakha. Iphuma ku-cellulose eshintshwe ngokusabela kwamakhemikhali ukuze kuthuthukiswe izici zayo. Le polymer ibonakala ngokuncibilika kwamanzi, i-biocompatibility, namandla okwenza ifilimu.
Isakhiwo samakhemikhali se-hydroxypropyl methylcellulose (HPMC):
IHydroxypropyl methylcellulose itholakala ku-cellulose, i-polysaccharide yemvelo etholakala ezindongeni zamaseli ezitshalo. Isakhiwo samakhemikhali se-HPMC sibonakala ngokuba khona kwamaqembu e-hydroxypropyl kanye ne-methyl kumgogodla we-cellulose.
Umgogodla weCellulose:
I-Cellulose iyi-polysaccharide eqondile eyakhiwe amayunithi e-glucose axhunywe ngamabhondi e-β-1,4-glycosidic. Amayunithi aphindayo akha amaketanga amade, aqinile ahlinzeka ngesisekelo sesakhiwo se-HPMC.
i-methyl:
Amaqembu e-Methyl (CH3) angeniswa kumgogodla we-cellulose ngokusabela kwamakhemikhali nge-methanol. Lokhu kushintsha kuthuthukisa i-hydrophobicity ye-polymer, kuthinta ukuncibilika kwayo kanye nezakhiwo zefilimu.
IHydroxypropyl:
Amaqembu e-Hydroxypropyl (C3H6O) anamathiselwe kumgogodla we-cellulose ngokusabela nge-propylene oxide. Lawa maqembu e-hydroxypropyl anomthelela ekuncibilikeni kwamanzi kwe-HPMC futhi abe nomthelela ekubonakaleni kwayo.
Izinga lokushintsha (DS) lamaqembu e-methyl kanye ne-hydroxypropyl lingahluka, kuthinte ukusebenza kukonke kwe-HPMC. I-DS ibhekisela enanini elimaphakathi leyunithi ngayinye ye-glucose kuketango le-cellulose.
Ukwenziwa kweHydroxypropyl Methylcellulose (HPMC):
Ukuhlanganiswa kwe-HPMC kuhilela izinyathelo zamakhemikhali ezimbalwa ezethula amaqembu e-methyl kanye ne-hydroxypropyl kumgogodla we-cellulose. Ukusabela okubalulekile kufaka i-etherification nge-methyl chloride kanye ne-hydroxypropylation nge-propylene oxide. Nakhu ukubuka konke okwenziwe lula:
Ukwenza kusebenze i-cellulose:
Inqubo iqala ngokuvula i-cellulose usebenzisa isisekelo, ngokuvamile i-sodium hydroxide. Lesi sinyathelo sinyusa ukusebenza kabusha kwamaqembu e-cellulose hydroxyl ngokusabela okulandelayo.
I-Methylation:
I-methyl chloride isetshenziselwa ukwethula amaqembu e-methyl. I-Cellulose ihlangana ne-methyl chloride phambi kwesisekelo, okuholela ekushintshweni kwamaqembu e-hydroxyl ngamaqembu e-methyl.
ukusabela:
I-Cellulose-OH+CH3Cl→Cellulose-OMe+Cellulose Hydrochloride-OH+CH3Cl→Cellulose-OMe+HCl
I-Hydroxypropylation:
Amaqembu e-Hydroxypropyl axhunywe kumgogodla we-cellulose esebenzisa i-propylene oxide. Ukusabela ngokuvamile kwenzeka endaweni ene-alkaline futhi izinga le-hydroxypropylation lilawulwa ukuze kuzuzwe izakhiwo ezidingekayo.
ukusabela:
I-Cellulose-OH+C3H6 i-oxygen→I-Cellulose-O-(CH2CH(OH)CH3)+H2 oxygen Cellulose-OH+C3H6O→Cellulose-O-(CH2CH(OH)CH3)+H2 oxygen
Ukungathathi hlangothi nokuhlanza:
Umkhiqizo owumphumela uyehliswa ukuze kukhishwe noma yiziphi izinsalela ezisele ezine-acidic noma eziyisisekelo. Izinyathelo zokuhlanza ezinjengokugeza nokuhlunga zenziwa ukuze kutholwe imikhiqizo yekhwalithi ephezulu ye-HPMC.
Izici Zekhemikhali ze-Hydroxypropyl Methylcellulose (HPMC):
Ukunyibilika:
I-HPMC incibilika kalula emanzini abandayo, futhi ukuncibilika kungalungiswa ngokushintsha izinga lokushintshwa. Amazinga aphezulu okushintsha ngokuvamile aphumela ekuncibilikeni okwandisiwe.
Ukwakhiwa kwefilimu:
I-HPMC inezinto ezinhle kakhulu zokwenza ifilimu, okuyenza ifaneleke izinhlelo zokusebenza ezifana nezingubo zemithi kanye nokupakishwa kokudla. Ifilimu ephumela obala futhi inikeza umgoqo wegesi.
I-Thermal Gelation:
I-Thermal Gelation iyimpahla ehlukile ye-HPMC. Ijeli yakha uma ishisa, futhi amandla ejeli ancike ezintweni ezifana nokugxila kanye nesisindo samangqamuzana.
I-Viscosity:
I-viscosity yezixazululo ze-HPMC ithintwa yizinga lokushintsha nokugxilisa ingqondo. Njenge-thickener, isetshenziswa kabanzi ezimbonini ezahlukahlukene.
Umsebenzi ongaphezulu:
I-HPMC inezinto ezifana ne-surfactant ezinikela emandleni ayo okuhlanganisa nokusimamisa ekwenziweni.
I-Biocompatibility:
I-HPMC ithathwa njenge-biocompatible, okuyenza ifanelekele ukusetshenziswa emithini yemithi, okuhlanganisa ukwakheka kwemithi ekhishwa okulawulwayo.
Izicelo ze-Hydroxypropyl Methylcellulose (HPMC):
umuthi:
I-HPMC ivamise ukusetshenziswa njengezibophezelo, izimbozo zefilimu, kanye namatrices okukhululwa okulawulwayo ekwenziweni kwemithi.
Bekezela:
Embonini yezokwakha, i-HPMC isetshenziswa njenge-ejenti yokugcina amanzi ezintweni ezisekelwe kusimende, ukuthuthukisa ukusebenza kahle nokunciphisa ukuhlukaniswa kwamanzi.
imboni yokudla:
I-HPMC isetshenziswa embonini yokudla njenge-thickener, stabilizer kanye ne-ejenti ye-gelling. Ivame ukusetshenziswa emikhiqizweni efana namasoso, amasobho kanye no-ayisikhilimu.
Imikhiqizo yokunakekelwa komuntu siqu:
Izimonyo Nokunakekelwa Kwezimboni Ukusebenzisa I-HPMC isetshenziswa emikhiqizweni efana nokhilimu kanye nezinto zokuthambisa ngenxa yokujiya kwayo kanye nezakhiwo zayo zokuhlanganisa.
Amapende nama-Coatings:
I-HPMC yengezwa kumapende nezingubo zokwengeza i-viscosity, ukuzinza nokugcinwa kwamanzi.
Ekuphetheni:
IHydroxypropyl methylcellulose iyi-polymer eguquguqukayo enezinhlobonhlobo zezinhlelo zokusebenza ngenxa yezakhiwo zayo zamakhemikhali ezihlukile. Ukuhlanganiswa kwe-HPMC kuhilela ukwethulwa kwamaqembu e-methyl kanye ne-hydroxypropyl kumgogodla we-cellulose, okuholela ku-polymer encibilika emanzini ne-biocompatible. Ukusetshenziswa kwayo okuhlukahlukene kwezemithi, ukwakhiwa, ukudla nokunakekelwa komuntu siqu kugqamisa ukubaluleka kwayo ezimbonini ezahlukahlukene. Njengoba ucwaningo luqhubeka, izinguquko ezengeziwe kanye nentuthuko kubuchwepheshe be-HPMC ingase ikhulise ukusetshenziswa kwayo futhi ithuthukise ukusebenza kwayo ezinhlelweni ezikhona nezisafufusa.
Isikhathi sokuthumela: Dec-18-2023