Okokuqala, isifinyezo sesiNgisi sezinto ezisizayo
MC: Methyl cellulose
EC: i-ethyl cellulose
I-HPC: i-hydroxypropyl cellulose
I-HPMC: i-hydroxypropyl methylcellulose
I-CAP: I-Cellulose acetate phthalates
I-HPMCP: i-hydroxypropyl cellulose phthalates
I-HPMCAS: i-hydroxypropyl methyl cellulose acetate succinate
Cmc-na: I-sodium carboxymethyl cellulose
I-MCC: I-Microcrystalline cellulose
I-PVP: I-Povidone
I-PEG: i-polyethylene glycol
I-PVA: I-Polyvinyl alcohol
Cms-na: isitashi se-sodium carboxymethyl
I-PVPP: I-povidone exhunywe ngokuphambana
I-CCNa: i-crosslinked sodium carboxymethyl cellulose
Okwesibili, ukusetshenziswa kwezinye izinto ezisizayo
1. Lactose: tablet: filler, ikakhulukazi powder ngqo tablet filler; Umjovo: isivikelo lyophilized
2. I-Microcrystalline cellulose: ithebhulethi: i-powder ecindezelwe ngokuqondile i-tablet filler; "I-adhesive eyomile"; Amaphilisi aqukethe u-20% we-microcrystalline cellulose asebenza njengama-disintegrators
3. I-Methyl cellulose: ithebhulethi: i-adhesive; I-ejenti yokumiswa: usizo lokumiswa; Ukulungiswa kokukhishwa okuhamba kancane (okulawulwayo): impahla ye-hydrophilic gel skeleton (ebuthakathaka)
4 sodium carboxymethyl cellulose: amaphilisi: ingcina; I-ejenti yokumiswa: usizo lokumiswa; Ukulungiswa kokukhululwa okunensayo (okulawulwayo): i-hydrophilic gel skeleton material
5. I-Ethyl cellulose: ithebhulethi: i-adhesive (engancibiliki emanzini); Ukulungiswa kokukhululwa okuhamba kancane (okulawulwayo): impahla yamathambo noma ulwelwesi olulawulwayo; Ukuhlakazeka okuqinile: impahla yenkampani yenethiwekhi engancibiliki
I-6 hydroxypropyl cellulose: ithebhulethi: i-adhesive, ifilimu yokugqoka impahla; I-ejenti yokumiswa: usizo lokumiswa; Ukulungiswa kokukhululwa okunensayo (okulawulwayo): i-hydrophilic gel skeleton material, ulwelwesi oluncane lwe-microporous coated sheet-inducing agent
7. I-Hydroxypropyl methyl cellulose (i-hydroxypropyl methyl cellulose) : ithebhulethi: i-adhesive, ifilimu yokugqoka impahla; I-ejenti yokumiswa: usizo lokumiswa; Ukulungiswa kokukhululwa okuhamba kancane futhi okulawulwayo: i-hydrophilic gel skeleton material, ulwelwesi oluncane lwe-microporous coated sheet-inducing agent
8. I-Cellulose acetate phthalates: impahla ye-enteric
9. I-Hydroxypropyl cellulose phthalates: impahla ye-enteric
10. I-Hydroxypropyl cellulose acetate succinate: impahla ye-enteric
11. I-Polyvinyl phthalate (PVAP): impahla ye-enteric
12. I-Styrene Maleic acid copolymer (StyMA): impahla encibilikayo emathunjini
13. I-Acrylic resin (uhlobo lwe-enteric I, II, III), i-Eudragit L, i-Eudragit S (ngezinye izikhathi i-Eudragit L100 noma i-Eudragit S 100) : izinto ezibonakalayo
14.Eudragit RL, Eudragit RS: : Izinto zenkampani yenethiwekhi ezingancibiliki
15.I-Eudragit E (ilingana ne-acrylic IV): impahla ye-polymer encibilikayo esiswini
16. I-Cellulose acetate: impahla engancibiliki emanzini, ingasetshenziselwa ukumboza noma ukulungisa amaphilisi epompo ye-osmotic
17. I-Polyvinylpyrrolidone (i-povidone PVP) : amaphilisi: ama-adhesives; Ithebhulethi: impahla yefilimu encibilikayo esiswini; Ama-pellets: i-nifedipine pellets (ukuhlakazeka okuqinile); I-ejenti yokumiswa: usizo lokumiswa;
Ukuhlakazeka okuqinile: impahla ethwala amanzi encibilika; Ukulungiswa kokukhululwa okuhamba kancane (okulawulwayo): impahla ye-hydrophilic colloid skeleton; Ukulungiswa kokukhululwa okunensayo (okulawulwayo): i-ejenti efaka izimbotshana kumaphilisi ambozwe nge-microporous membrane
18. I-Polyvinyl alcohol: i-ejenti yefilimu: izinto zokwakha ifilimu, usizo lokumiswa
19. I-sodium carboxymethyl isitashi: ithebhulethi: i-ejenti ehlakazayo
20. I-povidone exhunywe ngokuphambana: Ithebhulethi: i-disintegrant
21. I-Crosslinked sodium carboxymethyl cellulose: ithebhulethi: i-agent ehlukanisayo
22. I-hydroxypropyl cellulose efakwe endaweni ephansi: Ithebhulethi: i-disintegrant
23. I-Polylactic acid: i-biodegradable polymer material, esetshenziselwa ukulungiswa kwama-microspheres, ama-nanoparticles, njll.
24. I-Glycerol (i-sorbitol propylene glycol isebenza eduze ne-glycerol)
Amalungiselelo oketshezi: i-solvent, i-solvent yokujova, i-suspension aid, i-moisturizer
I-Plasticizer ku-capsule nezinto zokugqoka
Amafutha, amasistimu okulethwa kwe-transdermal: abagqugquzeli bokungena
Khulisa ukumanzisa kwezidakamizwa ze-hydrophobic, isilawuli sokucindezela kwe-osmotic ku-emulsion yamafutha e-intravenous
I-Glycerin gelatin (yamafutha, ama-suppositories, ama-dispersions aqinile)
25. I-gelatin ye-Glycerin
Amaphilisi okuwisa: i-matrix encibilikayo emanzini
I-Suppository: i-matrix encibilikayo emanzini
Amafutha: I-matrix encibilikayo emanzini
26. I-sodium dodecyl sulfate (i-anionic surfactant)
Ama-emulsions, amafutha okugcoba: ama-emulsifiers
I-ejenti yokumanzisa amalungiselelo aqinile/i-lubricant yamaphilisi
i-solubilizer
27. I-Polyethylene glycol (PEG)
Amathebulethi: I-lubricant encibilika emanzini (PEG 4000, 6000)
Ithebulethi: I-Plasticizer kumyalelo kadokotela wokumboza ifilimu
I-capsule: I-capsule ethambile engeyona i-oily liquid medium (PEG 400)
Amaphilisi okuwisa: I-matrix encibilikayo emanzini (PEG 4000, 6000,9300)
I-suppository: i-matrix ye-suppository
I-aerosol: I-Latent solvent (PEG 400, 600)
Umjovo: I-Solvent (PEG 400, 600)
Ukulungiswa koketshezi: I-Solvent (PEG 400, 600)
Ukuhlakazeka okuqinile: umthwali
Ukulungiswa kokukhululwa okunensayo (okulawulwayo): i-ejenti efaka izimbotshana kumaphilisi ambozwe nge-microporous membrane
Ukulungiselela ukumuncwa kwe-Percutaneous: isithuthukisi sokumuncwa kwe-transdermal
28. I-Poloxam (” zwitterionic “surfactant) Iqabane elicophelelayo liphawule umehluko lapha, manje olungisiwe ku-” Poloxam “i-non-ionic surfactant, hhayi i-surfactant ye-zwitterionic!
Isithwali sokuhlakazeka esiqinile, i-suppository matrix, i-emulsifier yomjovo noma ukumnika
Isifinyezo se-antiseptic kanye ne-bacteriostatic agents
IHydroxyl benzene ester (neper gold), benzoic acid, sodium benzoate, sorbic acid, benzalkonium bromide (new clean out), benzalkonium chloride (jie er die), i-chlorhexidine acetate, i-benzyl alcohol (ubuhlungu bendawo) ngesikhathi esifanayo, ixhumene enotshwala obuphezulu be-butyl (ubuhlungu bendawo) ngesikhathi esifanayo, i-nitrobenzene, i-mercury, i-thimerosal, inetha yokubulala amagciwane, i-ortho-phenyl phenol, i-phenoxyethanol, uwoyela we-eucalyptus, uwoyela wesinamoni, uwoyela we-peppermint, njll.
Okwesine, indlela yokuvala inzalo
1/ Umjovo weGlucose, i-emulsion yamafutha yokujova ngomjovo, i-dextran, ukumnika kwe-sodium chloride, ipulaki yerabha nokunye ukuvala inzalo okushisayo;
2/ Umjovo we-Vitamin C, umjovo we-procaine hydrochloride, umjovo we-cortisone acetate, amaconsi ehlo e-chloramphenicol abulawa inzalo ngomusi ojikelezayo;
3/ Amafutha omjovo, i-matrix kagrisi, i-ampoule esebenzisa indlela yokushisa inzalo eyomile;
I-4/ Igumbi lomoya we-Asepsis, indawo yetafula lokusebenza: indlela yokuvala inzalo ye-ultraviolet noma indlela yokufuthwa kwegesi;
5/ Isandla, imishini ye-aseptic: indlela yokuvala inzalo yamakhemikhali
6/ Umjovo we-insulin neminye imikhiqizo yebhayoloji: indlela yokuhlunga inzalo
V. Izibalo ezihlobene
1. I-Noyes-whitney equation: ichaza izinga lokuqedwa kwezidakamizwa eziqinile.
2. Umswakama obalulekile wengxube
i-hygroscopicity ye-P68 powder)
3. Intengo yokushintshai-suppository P87)
4.Ifomula ye-Poiseuile: chaza izici ezinethonya zokuhlunga (umjovo we-P124)
5. Ifomula yokubala yokulawulwa kwe-isotonic ngendlela yokwehlisa iphuzu lokuqandisaumjovo P156)
6. Ukubalwa kwevelu ye-HLB ye-surfactant exutshiweuketshezi P178)
Ubuchwepheshe bokulungiselela obufanele
1. I-Microcapsule: indlela yokufingqa (iyodwa, eyinkimbinkimbi), indlela yokuncibilikisa engancibiliki, indlela yokushintsha izinga lokushisa, indlela yokomisa uketshezi, indlela yokomisa isifutho, indlela yokufafaza yokufiphala, indlela yokumiswa komoya, indlela yokuhlanganisa isixhumi esibonakalayo, indlela yokunqamula ngemisebe
2. Inhlanganisela yokufakwa: indlela yesisombululo esinamanzi agcwele, indlela yokugaya, indlela yokumisa iqhwa, indlela yokumisa isifutho
3. Ukuhlakazeka okuqinile: indlela yokuncibilika, indlela yokuncibilikisa, indlela yokuncibilikisa, indlela yokuncibilikisa, indlela yokumisa isifutho, indlela yokugaya
4. Ama-Liposomes: indlela yomjovo, indlela yokuhlakaza ifilimu elincanyana, indlela yokuhlakazeka kwe-ultrasonic, indlela yokuhwamuka kwesigaba esibuyisela emuva, indlela yokumisa iqhwa
5. Ama-Microspheres: i-emulsification - indlela yokwelapha, indlela yokumisa isifutho, indlela yokomisa uketshezi
6. Ama-Nanoparticles: i-micellar polymerization, i-emulsion polymerization, i-interfacial polymerization, indlela yokomisa uketshezi
7. I-Pellet: indlela yokubilisa imbudumbudu, indlela yokufafaza imbudumbudu, indlela yebhodwe lokunamathela, indlela ye-extrusion sphericity, indlela ye-centrifugal projectile, indlela yokomisa uketshezi
8 suppository: indlela yokuncibilika okushisayo, indlela yokucindezela okubandayo, indlela yokuxova
9. Amafutha: indlela yokugaya, indlela yokuncibilika, indlela ye-emulsification
I-ejenti yefilimu eyi-10: indlela yokwenza ifilimu ye-slurry flow homogenized, indlela yokwenza ifilimu encibilika ngokucindezela, indlela yokwenza ifilimu eyinhlanganisela
Eziyisikhombisa, izesekeli ezimele
1. I-Microcapsule: i-gelatin - gum yesi-Arabhu
2. Inhlanganisela yokufakwa: i-cyclodextrin
3. Ukuhlakazeka okuqinile: I-PEG, i-PVP
4. I-Liposomes: i-phospholipid-cholesterol
5. Ama-Microspheres: i-gelatin, i-albumin, i-PLA, njll
6. I-Suppository: ibhotela le-cocoa
7. Amafutha: I-petroleum jelly, njll
8 i-ejenti yefilimu: i-PVA
Isishiyagalombili, izikhathi ezimbalwa
1. I-ampoule ehlanjululwe inzalo izoshiywa isikhathi esingekho ngaphezu kwamahora angama-24;
2. Ukugcinwa kwamanzi omjovo akufanele kudlule amahora ayi-12;
3. Ukuvala inzalo kwemijovo evamile kufanele kuqedwe phakathi namahora ayi-12 ngemva kokuphonswa kwembiza;
4. Ukumnika kanye nokulungiswa kwesixazululo kuzoqedwa phakathi namahora angu-4 okuvalwa inzalo
9. Izinto zokuhlola ikhwalithi ezihlobene namalungiselelo emithi
1. Amaphilisi: izici zokubukeka; Umehluko wesisindo socezu; Ukuqina nokuqina; Disintegrating degree; Ukuchithwa noma ukukhululwa; Ukufana kokuqukethwe
2. I-ejenti ehlakazayo: ukufana; Umswakama. Ilayisha umehluko wenani; Ukuhlolwa kwezempilo; Ukuhlolwa kwe-granularity
3. I-Granule: ukubukeka; Usayizi wezinhlayiya; Ukulahlekelwa isisindo esomile; Ncibilikisa; Umehluko womthwalo
4. I-Capsule: ukubukeka; Umswakama. Ilayisha umehluko wenani; Ukuhlakazeka nokuhlakazeka.
5. Amaphilisi okuwisa: umehluko wesisindo; Ukuhlolwa komkhawulo wesikhathi sokuqedwa, njll.
6. I-Suppository: ukubukeka; Umehluko ngesisindo; Umkhawulo wesikhathi sokuncibilika; Ibanga lephoyinti lokuncibilika; Ukuhlolwa kwe-in vitro dissolution kanye nokuhlolwa kokumuncwa kwe-vivo
7. Upulasi: usayizi wezinhlayiyana; Umthwalo; Umkhawulo we-Microbial; Okuqukethwe kwezidakamizwa eziyinhloko; Izakhiwo zomzimba; Isikhuthazo; Ukuzinza; Ukukhishwa, ukungena kanye nokumuncwa kwezidakamizwa kumafutha.
8. Amapheshana e-Transdermal: umehluko wesisindo; Umehluko wendawo; Ukufana kokuqukethwe; Idigri yokukhishwa, njll.
10. Izincazelo ezahlukene
1. I-capsule encane: i-capsule encane eyakhiwe ngokugoqa umuthi oqinile noma owuketshezi (obizwa ngokuthi i-capsule core) ezintweni ze-polymer zemvelo noma zokwenziwa (ezibizwa ngokuthi i-capsule material). 1-5000 microns
2. I-Pellet: ibhekisela ebhizinisini eliyindilinga elinobubanzi obungaphansi kuka-2.5mm olwakhiwe izidakamizwa nezinto ezisizayo.
3. I-Microsphere: i-microsphere yohlobo lwamathambo e-microscopic esungulwe ngokuncibilika noma izidakamizwa ezihlakazayo kuhlaka lwezinto ze-polymer, ezinosayizi wezinhlayiyana ngokuvamile phakathi kuka-1 no-250μm.
4. Ama-Nanoparticles: izinhlayiya eziqinile ze-colloidal ezakhiwe ngezinto ze-polymeric, ezinosayizi wezinhlayiyana kububanzi obuyi-10 ~ 1000nm.
5. I-ejenti yephilisi yokuwisa: ibhekisela ezidakamizweni eziqinile noma eziwuketshezi kanye nezinto ezifanele (ngokuvamile ezaziwa ngokuthi i-matrix) ingxube encibilikayo yokushisisa, iwela ku-condensate exubile, ukufinyela futhi okwenziwe ngamathayela amancane.
Isikhathi sokuthumela: Sep-09-2022